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Sökning: onr:"swepub:oai:prod.swepub.kib.ki.se:142915634" > Disruption of chrom...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 07528naa a2201405 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:142915634 | |
| 003 | SwePub | |
| 008 | 240913s2020 | |||||||||||000 ||eng| | |
| 009 | oai:lup.lub.lu.se:1228fbf0-3db4-4126-a102-77440ce7e8cd | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1429156342 URI |
| 024 | 7 | a https://doi.org/10.1038/s41588-019-0564-y2 DOI |
| 024 | 7 | a https://lup.lub.lu.se/record/1228fbf0-3db4-4126-a102-77440ce7e8cd2 URI |
| 040 | a (SwePub)kid (SwePub)lu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Akdemir, KCu University of Texas MD Anderson Cancer Center4 aut |
| 245 | 1 0 | a Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer |
| 264 | c 2020-02-05 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2020 |
| 520 | a Chromatin is folded into successive layers to organize linear DNA. Genes within the same topologically associating domains (TADs) demonstrate similar expression and histone-modification profiles, and boundaries separating different domains have important roles in reinforcing the stability of these features. Indeed, domain disruptions in human cancers can lead to misregulation of gene expression. However, the frequency of domain disruptions in human cancers remains unclear. Here, as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA), which aggregated whole-genome sequencing data from 2,658 cancers across 38 tumor types, we analyzed 288,457 somatic structural variations (SVs) to understand the distributions and effects of SVs across TADs. Notably, SVs can lead to the fusion of discrete TADs, and complex rearrangements markedly change chromatin folding maps in the cancer genomes. Notably, only 14% of the boundary deletions resulted in a change in expression in nearby genes of more than twofold. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
| 653 | a Chromatin/genetics | |
| 653 | a Gene Expression Regulation, Neoplastic | |
| 653 | a Gene Rearrangement/genetics | |
| 653 | a Genome, Human/genetics | |
| 653 | a Genomic Structural Variation | |
| 653 | a Humans | |
| 653 | a Neoplasms/genetics | |
| 700 | 1 | a Le, VTTu Salk Institute for Biological Studies4 aut |
| 700 | 1 | a Chandran, Su Salk Institute for Biological Studies4 aut |
| 700 | 1 | a Li, YLu Wellcome Trust Sanger Institute4 aut |
| 700 | 1 | a Verhaak, RGu QIMR Berghofer Medical Research Institute4 aut |
| 700 | 1 | a Beroukhim, Ru Dana-Farber Cancer Institute4 aut |
| 700 | 1 | a Campbell, PJu Wellcome Trust Sanger Institute4 aut |
| 700 | 1 | a Chin, Lu University of Texas4 aut |
| 700 | 1 | a Dixon, JRu Salk Institute for Biological Studies4 aut |
| 700 | 1 | a Futreal, PAu University of Texas MD Anderson Cancer Center4 aut |
| 700 | 1 | a Alvarez, EG4 aut |
| 700 | 1 | a Baez-Ortega, A4 aut |
| 700 | 1 | a Beroukhim, R4 aut |
| 700 | 1 | a Boutros, PC4 aut |
| 700 | 1 | a Bowtell, DDL4 aut |
| 700 | 1 | a Brors, B4 aut |
| 700 | 1 | a Burns, KH4 aut |
| 700 | 1 | a Chan, K4 aut |
| 700 | 1 | a Chen, K4 aut |
| 700 | 1 | a Cortes-Ciriano, I4 aut |
| 700 | 1 | a Dueso-Barroso, A4 aut |
| 700 | 1 | a Dunford, AJ4 aut |
| 700 | 1 | a Edwards, PA4 aut |
| 700 | 1 | a Estivill, X4 aut |
| 700 | 1 | a Etemadmoghadam, D4 aut |
| 700 | 1 | a Feuerbach, L4 aut |
| 700 | 1 | a Fink, JL4 aut |
| 700 | 1 | a Frenkel-Morgenstern, M4 aut |
| 700 | 1 | a Garsed, DW4 aut |
| 700 | 1 | a Gerstein, M4 aut |
| 700 | 1 | a Gordenin, DA4 aut |
| 700 | 1 | a Haan, D4 aut |
| 700 | 1 | a Haber, JE4 aut |
| 700 | 1 | a Hess, JM4 aut |
| 700 | 1 | a Hutter, B4 aut |
| 700 | 1 | a Imielinski, M4 aut |
| 700 | 1 | a Jones, DTW4 aut |
| 700 | 1 | a Ju, YS4 aut |
| 700 | 1 | a Kazanov, MD4 aut |
| 700 | 1 | a Klimczak, LJ4 aut |
| 700 | 1 | a Koh, Y4 aut |
| 700 | 1 | a Korbel, JO4 aut |
| 700 | 1 | a Kumar, K4 aut |
| 700 | 1 | a Lee, EA4 aut |
| 700 | 1 | a Lee, JJK4 aut |
| 700 | 1 | a Lynch, AG4 aut |
| 700 | 1 | a Macintyre, G4 aut |
| 700 | 1 | a Markowetz, F4 aut |
| 700 | 1 | a Martincorena, I4 aut |
| 700 | 1 | a Martinez-Fundichely, A4 aut |
| 700 | 1 | a Meyerson, M4 aut |
| 700 | 1 | a Miyano, S4 aut |
| 700 | 1 | a Nakagawa, H4 aut |
| 700 | 1 | a Navarro, FCP4 aut |
| 700 | 1 | a Ossowski, S4 aut |
| 700 | 1 | a Park, PJ4 aut |
| 700 | 1 | a Pearson, JV4 aut |
| 700 | 1 | a Puiggros, M4 aut |
| 700 | 1 | a Rippe, K4 aut |
| 700 | 1 | a Roberts, ND4 aut |
| 700 | 1 | a Roberts, SA4 aut |
| 700 | 1 | a Rodriguez-Martin, B4 aut |
| 700 | 1 | a Schumacher, SE4 aut |
| 700 | 1 | a Scully, R4 aut |
| 700 | 1 | a Shackleton, M4 aut |
| 700 | 1 | a Sidiropoulos, N4 aut |
| 700 | 1 | a Sieverling, L4 aut |
| 700 | 1 | a Stewart, C4 aut |
| 700 | 1 | a Torrents, D4 aut |
| 700 | 1 | a Tubio, JMC4 aut |
| 700 | 1 | a Villasante, I4 aut |
| 700 | 1 | a Waddell, N4 aut |
| 700 | 1 | a Wala, JA4 aut |
| 700 | 1 | a Weischenfeldt, J4 aut |
| 700 | 1 | a Yang, LX4 aut |
| 700 | 1 | a Yao, XT4 aut |
| 700 | 1 | a Yoon, SS4 aut |
| 700 | 1 | a Zamora, J4 aut |
| 700 | 1 | a Zhang, CZ4 aut |
| 700 | 1 | a Borg, Åkeu Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Familjär bröstcancer,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Familial Breast Cancer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments4 cre0 (Swepub:lu)onk-abo |
| 700 | 1 | a Ringnér, Markusu Lund University,Lunds universitet,Molekylär cellbiologi,Biologiska institutionen,Naturvetenskapliga fakulteten,Molecular Cell Biology,Department of Biology,Faculty of Science4 cre0 (Swepub:lu)thep-mri |
| 700 | 1 | a Staaf, Johanu Lund University,Lunds universitet,Avdelningen för translationell cancerforskning,Institutionen för laboratoriemedicin,Medicinska fakulteten,Forskningsgrupp Lungcancer,Forskargrupper vid Lunds universitet,LUCC: Lunds universitets cancercentrum,Övriga starka forskningsmiljöer,Bröst/lungcancer,Sektion I,Institutionen för kliniska vetenskaper, Lund,Division of Translational Cancer Research,Department of Laboratory Medicine,Faculty of Medicine,Research Group Lung Cancer,Lund University Research Groups,LUCC: Lund University Cancer Centre,Other Strong Research Environments,Breast/lungcancer,Section I,Department of Clinical Sciences, Lund4 cre0 (Swepub:lu)onk-jst |
| 710 | 2 | a University of Texas MD Anderson Cancer Centerb Salk Institute for Biological Studies4 org |
| 710 | 2 | a PCAWG Consortium |
| 773 | 0 | t Nature geneticsd : Springer Science and Business Media LLCg 52:3, s. 294-+q 52:3<294-+x 1546-1718x 1061-4036 |
| 856 | 4 | u https://www.nature.com/articles/s41588-019-0564-y.pdf |
| 856 | 4 | u http://dx.doi.org/10.1038/s41588-019-0564-yx freey FULLTEXT |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:142915634 |
| 856 | 4 8 | u https://doi.org/10.1038/s41588-019-0564-y |
| 856 | 4 8 | u https://lup.lub.lu.se/record/1228fbf0-3db4-4126-a102-77440ce7e8cd |
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