Sökning: onr:"swepub:oai:prod.swepub.kib.ki.se:146070513" > The age of adult pi...
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000 | 02983naa a2200481 4500 | |
001 | oai:prod.swepub.kib.ki.se:146070513 | |
003 | SwePub | |
008 | 240913s2021 | |||||||||||000 ||eng| | |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1460705132 URI |
024 | 7 | a https://doi.org/10.1038/s41388-021-01738-02 DOI |
040 | a (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Voronina, N4 aut |
245 | 1 0 | a The age of adult pilocytic astrocytoma cells |
264 | c 2021-03-17 | |
264 | 1 | b Springer Science and Business Media LLC,c 2021 |
520 | a Adult pilocytic astrocytomas (PAs) have been regarded as indistinguishable from pediatric PAs in terms of genome-wide expression and methylation patterns. It has been unclear whether adult PAs arise early in life and remain asymptomatic until adulthood, or whether they develop during adulthood. We sought to determine the age and origin of adult human PAs using two types of “marks” in the genomic DNA. First, we analyzed the DNA methylation patterns of adult and pediatric PAs to distinguish between PAs of different anatomic locations (n = 257 PA and control brain tissues). Second, we measured the concentration of nuclear bomb test-derived 14C in genomic DNA (n = 14 cases), which indicates the time point of the formation of human cell populations. Our data suggest that adult and pediatric PAs developing in the infratentorial brain are closely related and potentially develop from precursor cells early in life, whereas supratentorial PAs might show age and location-specific differences. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
700 | 1 | a Aichmuller, C4 aut |
700 | 1 | a Kolb, T4 aut |
700 | 1 | a Korshunov, A4 aut |
700 | 1 | a Ryzhova, M4 aut |
700 | 1 | a Barnholtz-Sloan, J4 aut |
700 | 1 | a Cioffi, G4 aut |
700 | 1 | a Sill, M4 aut |
700 | 1 | a von Deimling, A4 aut |
700 | 1 | a Pfister, SM4 aut |
700 | 1 | a Gronych, J4 aut |
700 | 1 | a Jones, DTW4 aut |
700 | 1 | a Frisen, Ju Karolinska Institutet4 aut |
700 | 1 | a Zapatka, M4 aut |
700 | 1 | a Ernst, A4 aut |
710 | 2 | a Karolinska Institutet4 org |
773 | 0 | t Oncogened : Springer Science and Business Media LLCg 40:16, s. 2830-2841q 40:16<2830-2841x 1476-5594x 0950-9232 |
856 | 4 | u https://www.nature.com/articles/s41388-021-01738-0.pdf |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:146070513 |
856 | 4 8 | u https://doi.org/10.1038/s41388-021-01738-0 |
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