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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02654naa a2200337 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:146104530 | |
| 003 | SwePub | |
| 008 | 240811s2021 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1461045302 URI |
| 024 | 7 | a https://doi.org/10.1038/s41598-021-82498-52 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Szurgot, Iu Karolinska Institutet4 aut |
| 245 | 1 0 | a DNA-launched RNA replicon vaccines induce potent anti-SARS-CoV-2 immune responses in mice |
| 264 | c 2021-02-04 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2021 |
| 520 | a The outbreak of the SARS-CoV-2 virus and its rapid spread into a global pandemic made the urgent development of scalable vaccines to prevent coronavirus disease (COVID-19) a global health and economic imperative. Here, we characterized and compared the immunogenicity of two alphavirus-based DNA-launched self-replicating (DREP) vaccine candidates encoding either SARS-CoV-2 spike glycoprotein (DREP-S) or a spike ectodomain trimer stabilized in prefusion conformation (DREP-Secto). We observed that the two DREP constructs were immunogenic in mice inducing both binding and neutralizing antibodies as well as T cell responses. Interestingly, the DREP coding for the unmodified spike turned out to be more potent vaccine candidate, eliciting high titers of SARS-CoV-2 specific IgG antibodies that were able to efficiently neutralize pseudotyped virus after a single immunization. In addition, both DREP constructs were able to efficiently prime responses that could be boosted with a heterologous spike protein immunization. These data provide important novel insights into SARS-CoV-2 vaccine design using a rapid response DNA vaccine platform. Moreover, they encourage the use of mixed vaccine modalities as a strategy to combat SARS-CoV-2. | |
| 700 | 1 | a Hanke, Lu Karolinska Institutet4 aut |
| 700 | 1 | a Sheward, DJu Karolinska Institutet4 aut |
| 700 | 1 | a Vidakovics, LPu Karolinska Institutet4 aut |
| 700 | 1 | a Murrell, Bu Karolinska Institutet4 aut |
| 700 | 1 | a McInerney, GMu Karolinska Institutet4 aut |
| 700 | 1 | a Liljestrom, P4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t Scientific reportsd : Springer Science and Business Media LLCg 11:1, s. 3125-q 11:1<3125-x 2045-2322 |
| 856 | 4 | u https://www.nature.com/articles/s41598-021-82498-5.pdf |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:146104530 |
| 856 | 4 8 | u https://doi.org/10.1038/s41598-021-82498-5 |
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