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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02834naa a2200313 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:146930742 | |
| 003 | SwePub | |
| 008 | 240701s2021 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1469307422 URI |
| 024 | 7 | a https://doi.org/10.3390/biomedicines90606972 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Ntika, Su Karolinska Institutet4 aut |
| 245 | 1 0 | a Syndecan-1 Expression Is Increased in the Aortic Wall of Patients with Type 2 Diabetes but Is Unrelated to Elevated Fasting Plasma Glucagon-Like Peptide-1 |
| 264 | c 2021-06-20 | |
| 264 | 1 | b MDPI AG,c 2021 |
| 520 | a A reduced prevalence of a thoracic aortic aneurysm (thoracic AA) is observed in type 2 diabetes (T2D). Glucagon-like peptide-1 (GLP-1)/GLP-1-based anti-diabetic therapy has indicated protective effects in thoracic AA and regulates the processes controlling the vascular tissue expression of Syndecan-1 (Sdc-1). Sdc-1 expression on macrophages infiltrating the aortic tissue contributes to a counter-regulatory response to thoracic AA formation in animal models through the interplay with inflammation/proteolytic activity. We hypothesized that elevated fasting plasma GLP-1 (fpGLP-1) increases the aortic Sdc-1 expression in T2D, which may contribute to a reduced prevalence of thoracic AA. Consequently, we determined whether T2D/thoracic AA associates with an altered Sdc-1 expression in the aortic tissue and the possible associations with fpGLP-1 and inflammation/proteolytic activity. From a cohort of surgical patients with an aortic valve pathology, we compared different disease groups (T2D/thoracic AA) with the same sub-cohort group of controls (patients without T2D and thoracic AA). The MMP-2 activity and Sdc-1, GLP-1R and CD68 expression were analyzed in the aortic tissue. GLP-1, Sdc-1 and cytokines were analyzed in the plasma. The aortic Sdc-1 expression was increased in T2D patients but did not correlate with fpGLP-1. Thoracic AA was associated with an increased aortic expression of Sdc-1 and the macrophage marker CD68. CD68 was not detected in T2D. In conclusion, an increased aortic Sdc-1 expression may contribute to a reduced prevalence of thoracic AA in T2D. | |
| 700 | 1 | a Tracy, LM4 aut |
| 700 | 1 | a Franco-Cereceda, Au Karolinska Institutet4 aut |
| 700 | 1 | a Bjorck, HMu Karolinska Institutet4 aut |
| 700 | 1 | a Krizhanovskii, C4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t Biomedicinesd : MDPI AGg 9:6q 9:6x 2227-9059 |
| 856 | 4 | u https://www.mdpi.com/2227-9059/9/6/697/pdf |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:146930742 |
| 856 | 4 8 | u https://doi.org/10.3390/biomedicines9060697 |
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