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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 02347naa a2200289 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:148189999 | |
| 003 | SwePub | |
| 008 | 240701s2021 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1481899992 URI |
| 024 | 7 | a https://doi.org/10.1093/ecco-jcc/jjab0852 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Selin, KAu Karolinska Institutet4 aut |
| 245 | 1 0 | a Immunological Networks Defining the Heterogeneity of Inflammatory Bowel Diseases |
| 264 | c 2021-05-07 | |
| 264 | 1 | b Oxford University Press (OUP),c 2021 |
| 520 | a Current practice in IBD is to classify patients based on clinical signs and symptoms and provide treatments accordingly. However, the response of IBD patients to available treatments is highly variable, highlighting clinically significant heterogeneity among patients. Thus, more accurate patient stratification is urgently needed to more effectively target therapeutic interventions to specific patients. Here we review the degree of heterogeneity in IBD, discussing how the microbiota, genetics, and immune system may contribute to the variation among patients. We highlight how molecular heterogeneity may relate to clinical phenotype, but in other situations may be independent of clinical phenotype, encouraging future studies to fill the gaps. Finally, we discuss novel stratification methodologies as a foundation for precision medicine, in particular a novel stratification strategy based on conserved genes across species. All of these dimensions of heterogeneity have potential to provide strategies for patient stratification and move IBD practice towards personalised medicine. | |
| 700 | 1 | a Hedin, CRHu Karolinska Institutet4 aut |
| 700 | 1 | a Villablanca, EJu Karolinska Institutet4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t Journal of Crohn's & colitisd : Oxford University Press (OUP)g 15:11, s. 1959-1973q 15:11<1959-1973x 1876-4479x 1873-9946 |
| 856 | 4 | u https://academic.oup.com/ecco-jcc/advance-article-pdf/doi/10.1093/ecco-jcc/jjab085/40147456/jjab085.pdf |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:148189999 |
| 856 | 4 8 | u https://doi.org/10.1093/ecco-jcc/jjab085 |
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