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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 03312naa a2200529 4500 | |
| 001 | oai:prod.swepub.kib.ki.se:148397283 | |
| 003 | SwePub | |
| 008 | 240701s2022 | |||||||||||000 ||eng| | |
| 024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1483972832 URI |
| 024 | 7 | a https://doi.org/10.1038/s41409-021-01551-z2 DOI |
| 040 | a (SwePub)ki | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Bethge, WA4 aut |
| 245 | 1 0 | a Results of a multicenter phase I/II trial of TCRαβ and CD19-depleted haploidentical hematopoietic stem cell transplantation for adult and pediatric patients |
| 264 | c 2021-12-24 | |
| 264 | 1 | b Springer Science and Business Media LLC,c 2022 |
| 520 | a Hematopoietic stem cell transplantation (HSCT) from haploidentical donors is a viable option for patients lacking HLA-matched donors. Here we report the results of a prospective multicenter phase I/II trial of transplantation of TCRαβ and CD19-depleted peripheral blood stem cells from haploidentical family donors after a reduced-intensity conditioning with fludarabine, thiotepa, and melphalan. Thirty pediatric and 30 adult patients with acute leukemia (n = 43), myelodysplastic or myeloproliferative syndrome (n = 6), multiple myeloma (n = 1), solid tumors (n = 6), and non-malignant disorders (n = 4) were enrolled. TCR αβ/CD19-depleted grafts prepared decentrally at six manufacturing sites contained a median of 12.1 × 106 CD34+ cells/kg and 14.2 × 103 TCRαβ+ T-cells/kg. None of the patients developed grade lll/IV acute graft-versus-host disease (GVHD) and only six patients (10%) had grade II acute GVHD. With a median follow-up of 733 days 36/60 patients are alive. The cumulative incidence of non-relapse mortality at day 100, 1 and 2 years after HSCT was 5%, 15%, and 17% for all patients, respectively. Estimated probabilities of overall and disease-free survival at 2 years were 63% and 50%, respectively. Based on these promising results in a high-risk patient cohort, haploidentical HSCT using TCRαβ/CD19-depleted grafts represents a viable treatment option. | |
| 700 | 1 | a Eyrich, M4 aut |
| 700 | 1 | a Mielke, Su Karolinska Institutet4 aut |
| 700 | 1 | a Meisel, R4 aut |
| 700 | 1 | a Niederwieser, D4 aut |
| 700 | 1 | a Schlegel, PG4 aut |
| 700 | 1 | a Schulz, A4 aut |
| 700 | 1 | a Greil, J4 aut |
| 700 | 1 | a Bunjes, D4 aut |
| 700 | 1 | a Brecht, A4 aut |
| 700 | 1 | a Kuball, J4 aut |
| 700 | 1 | a Schumm, M4 aut |
| 700 | 1 | a Vucinic, V4 aut |
| 700 | 1 | a Wiesneth, M4 aut |
| 700 | 1 | a Bonig, H4 aut |
| 700 | 1 | a Westinga, K4 aut |
| 700 | 1 | a Biedermann, S4 aut |
| 700 | 1 | a Holtkamp, S4 aut |
| 700 | 1 | a Karitzky, S4 aut |
| 700 | 1 | a Malchow, M4 aut |
| 700 | 1 | a Siewert, C4 aut |
| 700 | 1 | a Handgretinger, R4 aut |
| 700 | 1 | a Lang, P4 aut |
| 710 | 2 | a Karolinska Institutet4 org |
| 773 | 0 | t Bone marrow transplantationd : Springer Science and Business Media LLCg 57:3, s. 423-430q 57:3<423-430x 1476-5365x 0268-3369 |
| 856 | 4 | u https://www.nature.com/articles/s41409-021-01551-z.pdf |
| 856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:148397283 |
| 856 | 4 8 | u https://doi.org/10.1038/s41409-021-01551-z |
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