onr:"swepub:oai:prod.swepub.kib.ki.se:150411234"
Search: onr:"swepub:oai:prod.swepub.kib.ki.se:150411234" > Mobilization of sys...
- 1 of 1
- Previous record
- Next record
- To hitlist
Mobilization of systemic CCL4 following HIV pre-exposure prophylaxis in young men in Africa
- Petkov, S (author)
- Herrera, C (author)
- Else, L (author)
- show more...
- Mugaba, S (author)
- Namubiru, P (author)
- Odoch, G (author)
- Opoka, D (author)
- Pillay, ADAP (author)
- Seiphetlo, TB (author)
- Serwanga, J (author)
- Ssemata, AS (author)
- Kaleebu, P (author)
- Webb, EL (author)
- Khoo, S (author)
- Lebina, L (author)
- Gray, CM (author)
- Martinson, N (author)
- Fox, J (author)
- show less...
- (creator_code:org_t)
- 2022-07-27
- 2022
- English.
- In: Frontiers in immunology. - : Frontiers Media SA. - 1664-3224. ; 13, s. 965214-
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- HIV-1 pre-exposure prophylaxis (PrEP) relies on inhibition of HIV-1 replication steps. To understand how PrEP modulates the immunological environment, we derived the plasma proteomic profile of men receiving emtricitabine-tenofovir (FTC-TDF) or emtricitabine-tenofovir alafenamide (FTC-TAF) during the CHAPS trial in South Africa and Uganda (NCT03986970). The CHAPS trial randomized 144 participants to one control and 8 PrEP arms, differing by drug type, number of PrEP doses and timing from final PrEP dose to sampling. Blood was collected pre- and post-PrEP. The inflammatory profile of plasma samples was analyzed using Olink (N=92 proteins) and Luminex (N=33) and associated with plasma drug concentrations using mass spectrometry. The proteins whose levels changed most significantly from pre- to post-PrEP were CCL4, CCL3 and TNF-α; CCL4 was the key discriminator between pre- and post-PrEP samples. CCL4 and CCL3 levels were significantly increased in post-PrEP samples compared to control specimens. CCL4 was significantly correlated with FTC drug levels in plasma. Production of inflammatory chemokines CCL4 and CCL3 in response to short-term PrEP indicates the mobilization of ligands which potentially block virus attachment to CCR5 HIV-1 co-receptor. The significant correlation between CCL4 and FTC levels suggests that CCL4 increase is modulated as an inflammatory response to PrEP.
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
- Frontiers in immunology (Search for host publication in LIBRIS)
To the university's database
- 1 of 1
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Petkov, S
- Herrera, C
- Else, L
- Mugaba, S
- Namubiru, P
- Odoch, G
- show more...
- Opoka, D
- Pillay, ADAP
- Seiphetlo, TB
- Serwanga, J
- Ssemata, AS
- Kaleebu, P
- Webb, EL
- Khoo, S
- Lebina, L
- Gray, CM
- Martinson, N
- Fox, J
- Chiodi, F
- show less...
- Articles in the publication
- Frontiers in imm ...
- By the university
- Karolinska Institutet
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
