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Ten-year survival o...
Ten-year survival of children with trisomy 13 or trisomy 18: a multi-registry European cohort study
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Glinianaia, SV (författare)
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Rankin, J (författare)
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Tan, JC (författare)
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Loane, M (författare)
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Garne, E (författare)
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Cavero-Carbonell, C (författare)
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de Walle, HEK (författare)
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Gatt, M (författare)
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- Gissler, M (författare)
- Karolinska Institutet
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Klungsoyr, K (författare)
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Lelong, N (författare)
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Neville, A (författare)
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Pierini, A (författare)
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Tucker, DF (författare)
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Urhoj, SK (författare)
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Wellesley, DG (författare)
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Morris, JK (författare)
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(creator_code:org_t)
- 2023-03-07
- 2023
- Engelska.
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Ingår i: Archives of disease in childhood. - : BMJ. - 1468-2044 .- 0003-9888. ; 108:6, s. 461-467
- Relaterad länk:
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http://kipublication...
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https://doi.org/10.1...
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Abstract
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- To investigate the survival to 10 years of age of children with trisomy 13 (T13) and children with trisomy 18 (T18), born 1995–2014.DesignPopulation-based cohort study that linked mortality data to data on children born with T13 or T18, including translocations and mosaicisms, from 13 member registries of EUROCAT, a European network for the surveillance of congenital anomalies.Setting13 regions in nine Western European countries.Patients252 live births with T13 and 602 with T18.Main outcome measuresSurvival at 1 week, 4 weeks and 1, 5 and 10 years of age estimated by random-effects meta-analyses of registry-specific Kaplan-Meier survival estimates.ResultsSurvival estimates of children with T13 were 34% (95% CI 26% to 46%), 17% (95% CI 11% to 29%) and 11% (95% CI 6% to 18%) at 4 weeks, 1 and 10 years, respectively. The corresponding survival estimates were 38% (95% CI 31% to 45%), 13% (95% CI 10% to 17%) and 8% (95% CI 5% to 13%) for children with T18. The 10-year survival conditional on surviving to 4 weeks was 32% (95% CI 23% to 41%) and 21% (95% CI 15% to 28%) for children with T13 and T18, respectively.ConclusionsThis multi-registry European study found that despite extremely high neonatal mortality in children with T13 and T18, 32% and 21%, respectively, of those who survived to 4 weeks were likely to survive to age 10 years. These reliable survival estimates are useful to inform counselling of parents after prenatal diagnosis.
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Glinianaia, SV
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Rankin, J
-
Tan, JC
-
Loane, M
-
Garne, E
-
Cavero-Carbonell ...
-
visa fler...
-
de Walle, HEK
-
Gatt, M
-
Gissler, M
-
Klungsoyr, K
-
Lelong, N
-
Neville, A
-
Pierini, A
-
Tucker, DF
-
Urhoj, SK
-
Wellesley, DG
-
Morris, JK
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visa färre...
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Archives of dise ...
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Karolinska Institutet