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Both CD4+ and CD8+ ...
Both CD4+ and CD8+ T cells are essential to induce experimental autoimmune myasthenia gravis
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Zhang, GX (author)
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Xiao, BG (author)
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Bakhiet, M (author)
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vanderMeide, P (author)
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- Wigzell, H (author)
- Karolinska Institutet
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- Link, H (author)
- Karolinska Institutet
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- Olsson, T (author)
- Karolinska Institutet
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(creator_code:org_t)
- 1996-08-01
- 1996
- English.
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In: The Journal of experimental medicine. - : Rockefeller University Press. - 0022-1007 .- 1540-9538. ; 184:2, s. 349-356
- Related links:
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http://jem.rupress.o...
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http://kipublication...
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https://doi.org/10.1...
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Abstract
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- CD4+ T cells have been shown to be crucial in the development of experimental autoimmune myasthenia gravis (EAMG). The role of CD8+ T cells in EAMG is less well established. We previously showed that antibody depletion of CD8+ T cells in rats effectively suppresses EAMG. To further study the role and relationship of CD4+ versus CD8+ T cells in induction of EAMG, CD4-/-, CD8-/-, and CD4-8- mutant C57BL/6 mice and the parent CD4+8- wild-type mice were immunized with Torpedo acetylcholine receptor (AChR) plus complete Freund's adjuvant. Clinical EAMG was nearly completely prevented in CD4-8-, CD4-/-, and CD8-/- mice. This was associated with strongly reduced AChR-specific T and B cell responses, and with reduced levels of AChR-reactive interferon gamma (IFN-gamma) and interleukin 4 (IL-4) mRNA-expressing cells in lymphoid organs when compared with CD4+8+ wild-type mice. We conclude that (a) both CD4+ and CD8+ T cells are essential for development of EAMG, and a collaboration between these cell types may be necessary; (b) CD4+ as well as CD8+ T cells secrete IFN-gamma and IL-4, and both cytokines are involved in the development of EAMG; and (c), besides T cells, other immune cells might also be responsible for help of anti-AChR antibody production.
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