Search: onr:"swepub:oai:prod.swepub.kib.ki.se:232743605" >
The best COVID-19 p...
The best COVID-19 predictor is recent smell loss: a cross-sectional study
- Article/chapterEnglish2020
Publisher, publication year, extent ...
-
Cold Spring Harbor Laboratory,2020
Numbers
-
LIBRIS-ID:oai:prod.swepub.kib.ki.se:232743605
-
http://kipublications.ki.se/Default.aspx?queryparsed=id:232743605URI
-
https://doi.org/10.1101/2020.07.22.20157263DOI
Supplementary language notes
-
Language:English
-
Summary in:English
Part of subdatabase
Classification
-
Subject category:vet swepub-contenttype
-
Subject category:art swepub-publicationtype
Notes
-
BackgroundCOVID-19 has heterogeneous manifestations, though one of the most common symptoms is a sudden loss of smell (anosmia or hyposmia). We investigated whether olfactory loss is a reliable predictor of COVID-19.MethodsThis preregistered, cross-sectional study used a crowdsourced questionnaire in 23 languages to assess symptoms in individuals self-reporting recent respiratory illness. We quantified changes in chemosensory abilities during the course of the respiratory illness using 0-100 visual analog scales (VAS) for participants reporting a positive (C19+; n=4148) or negative (C19-; n=546) COVID-19 laboratory test outcome. Logistic regression models identified singular and cumulative predictors of COVID-19 status and post-COVID-19 olfactory recovery.ResultsBoth C19+ and C19-groups exhibited smell loss, but it was significantly larger in C19+ participants (mean±SD, C19+: -82.5±27.2 points; C19-: -59.8±37.7). Smell loss during illness was the best predictor of COVID-19 in both single and cumulative feature models (ROC AUC=0.72), with additional features providing negligible model improvement. VAS ratings of smell loss were more predictive than binary chemosensory yes/no-questions or other cardinal symptoms, such as fever or cough. Olfactory recovery within 40 days was reported for ∼50% of participants and was best predicted by time since illness onset.ConclusionsAs smell loss is the best predictor of COVID-19, we developed the ODoR-19 tool, a 0-10 scale to screen for recent olfactory loss. Numeric ratings ≤2 indicate high odds of symptomatic COVID-19 (4<OR<10), which can be deployed when viral lab tests are impractical or unavailable.
Added entries (persons, corporate bodies, meetings, titles ...)
-
Ohla, K
(author)
-
Veldhuizen, MG
(author)
-
Joseph, PV
(author)
-
Kelly, CE
(author)
-
Bakke, AJ
(author)
-
Steele, KE
(author)
-
Farruggia, MC
(author)
-
Pellegrino, R
(author)
-
Pepino, MY
(author)
-
Bouysset, C
(author)
-
Soler, GM
(author)
-
Pereda-Loth, V
(author)
-
Dibattista, M
(author)
-
Cooper, KW
(author)
-
Croijmans, I
(author)
-
Di Pizio, A
(author)
-
Ozdener, MH
(author)
-
Fjaeldstad, AW
(author)
-
Lin, C
(author)
-
Sandell, MA
(author)
-
Singh, PB
(author)
-
Brindha, VE
(author)
-
Olsson, SB
(author)
-
Saraiva, LR
(author)
-
Ahuja, G
(author)
-
Alwashahi, MK
(author)
-
Bhutani, S
(author)
-
D'Errico, A
(author)
-
Fornazieri, MA
(author)
-
Golebiowski, J
(author)
-
Hwang, LD
(author)
-
Öztürk, L
(author)
-
Roura, E
(author)
-
Spinelli, S
(author)
-
Whitcroft, KL
(author)
-
Faraji, F
(author)
-
Fischmeister, FPS
(author)
-
Heinbockel, T
(author)
-
Hsieh, JW
(author)
-
Huart, C
(author)
-
Konstantinidis, I
(author)
-
Menini, A
(author)
-
Morini, G
(author)
-
Olofsson, JK
(author)
-
Philpott, CM
(author)
-
Pierron, D
(author)
-
Shields, VDC
(author)
-
Voznessenskaya, VV
(author)
-
Albayay, J
(author)
-
Altundag, A
(author)
-
Bensafi, M
(author)
-
Bock, MA
(author)
-
Calcinoni, O
(author)
-
Fredborg, W
(author)
-
Laudamiel, C
(author)
-
Lim, J
(author)
-
Lundström, JNKarolinska Institutet
(author)
-
Macchi, A
(author)
-
Meyer, P
(author)
-
Moein, ST
(author)
-
Santamaría, E
(author)
-
Sengupta, D
(author)
-
Domínguez, PP
(author)
-
Yanık, H
(author)
-
Boesveldt, S
(author)
-
de Groot, JHB
(author)
-
Dinnella, C
(author)
-
Freiherr, J
(author)
-
Laktionova, T
(author)
-
Mariño, S
(author)
-
Monteleone, E
(author)
-
Nunez-Parra, A
(author)
-
Abdulrahman, O
(author)
-
Ritchie, M
(author)
-
Thomas-Danguin, T
(author)
-
Walsh-Messinger, J
(author)
-
Al Abri, R
(author)
-
Alizadeh, R
(author)
-
Bignon, E
(author)
-
Cantone, E
(author)
-
Cecchini, MP
(author)
-
Chen, J
(author)
-
Guàrdia, MD
(author)
-
Hoover, KC
(author)
-
Karni, N
(author)
-
Navarro, M
(author)
-
Nolden, AA
(author)
-
Mazal, PP
(author)
-
Rowan, NR
(author)
-
Sarabi-Jamab, A
(author)
-
Archer, NS
(author)
-
Chen, B
(author)
-
Di Valerio, EA
(author)
-
Feeney, EL
(author)
-
Frasnelli, J
(author)
-
Hannum, M
(author)
-
Hopkins, C
(author)
-
Klein, H
(author)
-
Mignot, C
(author)
-
Mucignat, C
(author)
-
Ning, Y
(author)
-
Ozturk, EE
(author)
-
Peng, M
(author)
-
Saatci, O
(author)
-
Sell, EA
(author)
-
Yan, CH
(author)
-
Alfaro, R
(author)
-
Cecchetto, C
(author)
-
Coureaud, G
(author)
-
Herriman, RD
(author)
-
Justice, JM
(author)
-
Kaushik, PK
(author)
-
Koyama, S
(author)
-
Overdevest, JB
(author)
-
Pirastu, N
(author)
-
Ramirez, VA
(author)
-
Roberts, SC
(author)
-
Smith, BC
(author)
-
Cao, H
(author)
-
Wang, H
(author)
-
Balungwe, P
(author)
-
Baguma, M
(author)
-
Hummel, T
(author)
-
Hayes, JE
(author)
-
Reed, DR
(author)
-
Niv, MY
(author)
-
Munger, SD
(author)
-
Parma, V
(author)
-
Karolinska Institutet
(creator_code:org_t)
Related titles
-
In:medRxiv : the preprint server for health sciences: Cold Spring Harbor Laboratory
Internet link
Find in a library
To the university's database
- By the author/editor
-
Gerkin, RC
-
Ohla, K
-
Veldhuizen, MG
-
Joseph, PV
-
Kelly, CE
-
Bakke, AJ
-
show more...
-
Steele, KE
-
Farruggia, MC
-
Pellegrino, R
-
Pepino, MY
-
Bouysset, C
-
Soler, GM
-
Pereda-Loth, V
-
Dibattista, M
-
Cooper, KW
-
Croijmans, I
-
Di Pizio, A
-
Ozdener, MH
-
Fjaeldstad, AW
-
Lin, C
-
Sandell, MA
-
Singh, PB
-
Brindha, VE
-
Olsson, SB
-
Saraiva, LR
-
Ahuja, G
-
Alwashahi, MK
-
Bhutani, S
-
D'Errico, A
-
Fornazieri, MA
-
Golebiowski, J
-
Hwang, LD
-
Öztürk, L
-
Roura, E
-
Spinelli, S
-
Whitcroft, KL
-
Faraji, F
-
Fischmeister, FP ...
-
Heinbockel, T
-
Hsieh, JW
-
Huart, C
-
Konstantinidis, ...
-
Menini, A
-
Morini, G
-
Olofsson, JK
-
Philpott, CM
-
Pierron, D
-
Shields, VDC
-
Voznessenskaya, ...
-
Albayay, J
-
Altundag, A
-
Bensafi, M
-
Bock, MA
-
Calcinoni, O
-
Fredborg, W
-
Laudamiel, C
-
Lim, J
-
Lundström, JN
-
Macchi, A
-
Meyer, P
-
Moein, ST
-
Santamaría, E
-
Sengupta, D
-
Domínguez, PP
-
Yanık, H
-
Boesveldt, S
-
de Groot, JHB
-
Dinnella, C
-
Freiherr, J
-
Laktionova, T
-
Mariño, S
-
Monteleone, E
-
Nunez-Parra, A
-
Abdulrahman, O
-
Ritchie, M
-
Thomas-Danguin, ...
-
Walsh-Messinger, ...
-
Al Abri, R
-
Alizadeh, R
-
Bignon, E
-
Cantone, E
-
Cecchini, MP
-
Chen, J
-
Guàrdia, MD
-
Hoover, KC
-
Karni, N
-
Navarro, M
-
Nolden, AA
-
Mazal, PP
-
Rowan, NR
-
Sarabi-Jamab, A
-
Archer, NS
-
Chen, B
-
Di Valerio, EA
-
Feeney, EL
-
Frasnelli, J
-
Hannum, M
-
Hopkins, C
-
Klein, H
-
Mignot, C
-
Mucignat, C
-
Ning, Y
-
Ozturk, EE
-
Peng, M
-
Saatci, O
-
Sell, EA
-
Yan, CH
-
Alfaro, R
-
Cecchetto, C
-
Coureaud, G
-
Herriman, RD
-
Justice, JM
-
Kaushik, PK
-
Koyama, S
-
Overdevest, JB
-
Pirastu, N
-
Ramirez, VA
-
Roberts, SC
-
Smith, BC
-
Cao, H
-
Wang, H
-
Balungwe, P
-
Baguma, M
-
Hummel, T
-
Hayes, JE
-
Reed, DR
-
Niv, MY
-
Munger, SD
-
Parma, V
-
show less...
- Articles in the publication
- medRxiv : the pr ...
- By the university
-
Karolinska Institutet