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Assessing lesion ma...
Assessing lesion malignancy by scanning small-angle x-ray scattering of breast tissue with microcalcifications
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- Arboled, C. (author)
- Eidgenössische Technische Hochschule Zürich (ETH),Swiss Federal Institute of Technology in Zürich (ETH),Paul Scherrer Institut,Paul Scherrer Institute,ETH Zürich
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- Lutz-Buen, V (author)
- Paul Scherrer Institut,Paul Scherrer Institute
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- Wang, Z. (author)
- Paul Scherrer Institut,Eidgenössische Technische Hochschule Zürich (ETH),Swiss Federal Institute of Technology in Zürich (ETH),Paul Scherrer Institute,ETH Zürich
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- Villanueva-Perez, P. (author)
- Paul Scherrer Institut,Deutsches Elektronen-Synchrotron (DESY),Paul Scherrer Institute,German Electron Synchrotron (DESY)
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- Guizar-Sicairos, M. (author)
- Paul Scherrer Institut,Paul Scherrer Institute
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- Liebi, Marianne, 1984 (author)
- Chalmers University of Technology,Lund University,Lunds universitet,MAX IV-laboratoriet,MAX IV Laboratory
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- Varga, Z. (author)
- Universitätsspital Zürich,University Hospital of Zürich,University Hospital of Zurich
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- Stampanoni, M. (author)
- Paul Scherrer Institut,Eidgenössische Technische Hochschule Zürich (ETH),Swiss Federal Institute of Technology in Zürich (ETH),ETH Zürich,Paul Scherrer Institute
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(creator_code:org_t)
- 2019-08-07
- 2019
- English.
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In: Physics in Medicine and Biology. - : IOP Publishing. - 0031-9155 .- 1361-6560. ; 64:15
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Abstract
Subject headings
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- Scanning small-angle x-ray scattering (SAXS) measurements were performed on 36 formalin-fixed breast tissue biopsies obtained from two patients. All samples contained microcalcifications of type II, i.e. formed by hydroxyapatite. We demonstrate the feasibility of classifying breast lesions by scanning SAXS of tissues containing microcalcifications with a resolution of 35 mu m x 30 mu m We report a characteristic Bragg peak found around q = 1.725 nm(-1) that occurs primarily for malignant lesions. Such a clear SAXS fingerprint is potentially linked to structural changes of breast tissue and corresponds to dimensions of about 3.7 nm. This material property could be used as an early indicator of malignancy development, as it is readily assessed by SAXS. If this fingerprint is combined with other known SAXS features, which also indicate the level of malignancy, such as lipid spacing and collagen periodicity, it could complement traditional pathology-based analyses. To confirm the SAXS-based classification, a histopathological workup and a gold standard histopathological diagnosis were conducted to determine the malignancy level of the lesions. Our aim is to report this SAXS fingerprint, which is clearly related to malignant breast lesions. However, any further conclusion based on our dataset is limited by the low number of patients and samples. Running a broad study to increase the number of samples and patients is of great importance and relevance for the breast-imaging community.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Keyword
- breast micro calcifications
- small-angle x-ray scattering
- breast cancer
- breast lesion diagnosis
- breast cancer
- breast lesion diagnosis
- breast micro calcifications
- small-angle x-ray scattering
Publication and Content Type
- art (subject category)
- ref (subject category)
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