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In Vitro Models for...
In Vitro Models for Studying Secondary Plant Metabolite Digestion and Bioaccessibility
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- Alminger, Marie, 1957 (author)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Aura, A. M. (author)
- Teknologian Tutkimuskeskus (VTT),Technical Research Centre of Finland (VTT)
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Bohn, T. (author)
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Dufour, C. (author)
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- El, S. N. (author)
- Ege Universitesi,Ege University
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- Gomes, A. (author)
- Nova University of Lisbon, Portugal
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- Karakaya, S. (author)
- Ege Universitesi,Ege University
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- Martinez-Cuesta, M. C. (author)
- Instituto de Investigación en Ciencias de la Alimentación CIAL (CSIC-UAM),Institute of Food Science Research (CIAL)
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- McDougall, G. J. (author)
- The James Hutton Institute
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- Requena, T. (author)
- Instituto de Investigación en Ciencias de la Alimentación CIAL (CSIC-UAM),Institute of Food Science Research (CIAL)
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- Santos, C. N. (author)
- Nova University of Lisbon, Portugal
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(creator_code:org_t)
- 2014-06-21
- 2014
- English.
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In: Comprehensive Reviews in Food Science and Food Safety. - : Wiley. - 1541-4337. ; 13:4, s. 413-436
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Abstract
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- There is an increased interest in secondary plant metabolites, such as polyphenols and carotenoids, due to their proposed health benefits. Much attention has focused on their bioavailability, a prerequisite for further physiological functions. As human studies are time consuming, costly, and restricted by ethical concerns, in vitro models for investigating the effects of digestion on these compounds have been developed and employed to predict their release from the food matrix, bioaccessibility, and assess changes in their profiles prior to absorption. Most typically, models simulate digestion in the oral cavity, the stomach, the small intestine, and, occasionally, the large intestine. A plethora of models have been reported, the choice mostly driven by the type of phytochemical studied, whether the purpose is screening or studying under close physiological conditions, and the availability of the model systems. Unfortunately, the diversity of model conditions has hampered the ability to compare results across different studies. For example, there is substantial variability in the time of digestion, concentrations of salts, enzymes, and bile acids used, pH, the inclusion of various digestion stages; and whether chosen conditions are static (with fixed concentrations of enzymes, bile salts, digesta, and so on) or dynamic (varying concentrations of these constituents). This review presents an overview of models that have been employed to study the digestion of both lipophilic and hydrophilic phytochemicals, comparing digestive conditions in vitro and in vivo and, finally, suggests a set of parameters for static models that resemble physiological conditions.
Subject headings
- LANTBRUKSVETENSKAPER -- Lantbruksvetenskap, skogsbruk och fiske -- Livsmedelsvetenskap (hsv//swe)
- AGRICULTURAL SCIENCES -- Agriculture, Forestry and Fisheries -- Food Science (hsv//eng)
- TEKNIK OCH TEKNOLOGIER -- Annan teknik -- Livsmedelsteknik (hsv//swe)
- ENGINEERING AND TECHNOLOGY -- Other Engineering and Technologies -- Food Engineering (hsv//eng)
Keyword
- in vitro models
- bioacessibility
- carotenoids
- gastrointestinal digestion
- polyphenols
- phytochemicals
Publication and Content Type
- for (subject category)
- ref (subject category)
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- By the author/editor
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Alminger, Marie, ...
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Aura, A. M.
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Bohn, T.
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Dufour, C.
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El, S. N.
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Gomes, A.
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show more...
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Karakaya, S.
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Martinez-Cuesta, ...
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McDougall, G. J.
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Requena, T.
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Santos, C. N.
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show less...
- About the subject
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- AGRICULTURAL SCIENCES
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AGRICULTURAL SCI ...
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and Agriculture Fore ...
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and Food Science
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- ENGINEERING AND TECHNOLOGY
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ENGINEERING AND ...
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and Other Engineerin ...
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and Food Engineering
- Articles in the publication
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Comprehensive Re ...
- By the university
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Chalmers University of Technology