Search: (L773:0036 8075 OR L773:1095 9203) lar1:(liu) >
Neurokinin 1 recept...
Neurokinin 1 receptor antagonism as a possible therapy for alcoholism
-
- George, David T. (author)
- National Institute on Alcohol Abuse and Alcoholism, NIH; Bethesda, MD, USA
-
- Gilman, Jodi (author)
- National Institute on Alcohol Abuse and Alcoholism, NIH; Bethesda, MD, USA
-
- Hersh, Jacqueline (author)
- National Institute on Alcohol Abuse and Alcoholism, NIH; Bethesda, MD, USA
-
show more...
-
- Thorsell, Annika (author)
- National Institute on Alcohol Abuse and Alcoholism, NIH; Bethesda, MD, USA
-
- Herion, David (author)
- National Institute on Alcohol Abuse and Alcoholism, NIH; Bethesda, MD, USA
-
- Geyer, Christopher (author)
- National Institutes of Health, Bethesda, NIH; Bethesda, MD, USA
-
- Peng, Xiaomei (author)
- Lilly Research Laboratories, Indianapolis, IN, USA
-
- Kielbasa, William (author)
- Lilly Research Laboratories, Indianapolis, IN, USA
-
- Rawlings, Robert (author)
- National Institute on Alcohol Abuse and Alcoholism, NIH; Bethesda, MD, USA
-
- Brandt, John E. (author)
- Lilly Research Laboratories, Indianapolis, IN, USA
-
- Gehlert, Donald R. (author)
- Lilly Research Laboratories, Indianapolis, IN, USA
-
- Tauscher, Johannes T. (author)
- Lilly Research Laboratories, Indianapolis, IN, USA
-
- Hunt, Stephen P. (author)
- University College London, UK
-
- Hommer, Daniel (author)
- National Institute on Alcohol Abuse and Alcoholism, NIH; Bethesda, MD, USA
-
- Heilig, Markus (author)
- National Institute on Alcohol Abuse and Alcoholism, NIH; Bethesda, MD, USA
-
show less...
-
(creator_code:org_t)
- American Association for the Advancement of Science, 2008
- 2008
- English.
-
In: Science. - : American Association for the Advancement of Science. - 0036-8075 .- 1095-9203. ; 319:5869, s. 1536-1539
- Related links:
-
https://urn.kb.se/re...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- Alcohol dependence is a major public health challenge in need of new treatments. As alcoholism evolves, stress systems in the brain play an increasing role in motivating continued alcohol use and relapse. We investigated the role of the neurokinin 1 receptor (NK1R), a mediator of behavioral stress responses, in alcohol dependence and treatment. In preclinical studies, mice genetically deficient in NK1R showed a marked decrease in voluntary alcohol consumption and had an increased sensitivity to the sedative effects of alcohol. In a randomized controlled experimental study, we treated recently detoxified alcoholic inpatients with an NK1R antagonist (LY686017; n = 25) or placebo (n = 25). LY686017 suppressed spontaneous alcohol cravings, improved overall well-being, blunted cravings induced by a challenge procedure, and attenuated concomitant cortisol responses. Brain functional magnetic resonance imaging responses to affective stimuli likewise suggested beneficial LY686017 effects. Thus, as assessed by these surrogate markers of efficacy, NK1R antagonism warrants further investigation as a treatment in alcoholism.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
-
Science
(Search for host publication in LIBRIS)
To the university's database
- By the author/editor
-
George, David T.
-
Gilman, Jodi
-
Hersh, Jacquelin ...
-
Thorsell, Annika
-
Herion, David
-
Geyer, Christoph ...
-
show more...
-
Peng, Xiaomei
-
Kielbasa, Willia ...
-
Rawlings, Robert
-
Brandt, John E.
-
Gehlert, Donald ...
-
Tauscher, Johann ...
-
Hunt, Stephen P.
-
Hommer, Daniel
-
Heilig, Markus
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Neurosciences
- Articles in the publication
-
Science
- By the university
-
Linköping University