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FältnamnIndikatorerMetadata
00007932naa a2200565 4500
001oai:DiVA.org:oru-102644
003SwePub
008221212s2023 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-1026442 URI
0247 a https://doi.org/10.1016/j.ogla.2022.11.0082 DOI
040 a (SwePub)oru
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Stuart, Kelsey V.u NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK4 aut
2451 0a The association of alcohol consumption with glaucoma and related traits :b findings from the UK Biobank
264 1b Elsevier,c 2023
338 a print2 rdacarrier
500 a Funding agencies:UCL Overseas Research Scholarship, Fight for Sight (London) 1956AThe Desmond FoundationMoorfields EyeCharity Springboard AwardGeneral Sir John Monash ScholarshipThe Glaucoma FoundationResearch to Prevent BlindnessNational Institutes of Health EY015473 EY032559 EY032559 EY027129 EY014104 EY022305 EY020928 EY031820) AerpioARVO FoundationDavid Epstein AwardAlconFight for Sight (London) 1956AUK Research and Innovation Future Leaders Fellowship MR/T040912/1Moorfields Eye Charity Career Development FellowshipLister Institute of Preventative Medicine FellowshipFoundation Trust and University College LondonInstitute of Ophthalmology for a Biomedical Research Centre
520 a PURPOSE: To examine the associations of alcohol consumption with glaucoma and related traits; to assess whether a genetic predisposition to glaucoma modified these associations; and to perform Mendelian randomization (MR) experiments to probe causal effects.DESIGN: Cross-sectional observational and gene-environment interaction analyses in the UK Biobank. Two-sample MR experiments using summary statistics from large genetic consortia.PARTICIPANTS: UK Biobank participants with data on intraocular pressure (IOP) (n=109 097), OCT derived macular inner retinal layer thickness measures (n=46 236) and glaucoma status (n=173 407).METHODS: Participants were categorized according to self-reported drinking behaviors. Quantitative estimates of alcohol intake were derived from touchscreen questionnaires and food composition tables. We performed a two-step analysis, first comparing categories of alcohol consumption (never, infrequent, regular, and former drinkers), before assessing for a dose-response effect in regular drinkers only. Multivariable linear, logistic and restricted cubic spline (RCS) regression, adjusted for key sociodemographic, medical, anthropometric and lifestyle factors, were used to examine associations. We assessed whether any association was modified by a multi-trait glaucoma polygenic risk score. The inverse-variance weighted method was used for the main MR analyses.MAIN OUTCOME MEASURES: IOP, macular retinal nerve fiber layer (mRNFL) thickness, macular ganglion cell-inner plexiform layer (mGCIPL) thickness, and prevalent glaucoma. RESULTS: Compared to infrequent drinkers, regular drinkers had higher IOP (+0.17mmHg; P<0.001) and thinner mGCIPL (-0.17μm; P=0.049); while former drinkers had a higher prevalence of glaucoma (OR 1.53; P=0.002). In regular drinkers, alcohol intake was adversely associated with all outcomes in a dose-dependent manner (all P<0.001). RCS regression analyses suggested non-linear associations, with apparent threshold effects at approximately 50g (∼6 UK or 4 US alcoholic units)/week, for mRNFL and mGCIPL thickness. Significantly stronger alcohol-IOP associations were observed in participants at higher genetic susceptibility to glaucoma (Pinteraction<0.001). MR analyses provided evidence for a causal association with mGCIPL thickness.CONCLUSIONS: Alcohol intake was consistently and adversely associated with glaucoma and related traits, and at levels below current UK (<112g/week) and US (women: <98g/week; men: <196g/week) guidelines. While we cannot infer causality definitively, these results will be of interest to people with, or at risk of, glaucoma and their advising physicians.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Oftalmologi0 (SwePub)302172 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Ophthalmology0 (SwePub)302172 hsv//eng
653 a Alcohol
653 a UK Biobank
653 a glaucoma
653 a intraocular pressure
653 a optical coherence tomography
7001 a Luben, Robert N.u NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK4 aut
7001 a Warwick, Alasdair N.u NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK; UCL Institute of Cardiovascular Science, University College London, London, UK4 aut
7001 a Madjedi, Kian M.u NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK; Department of Ophthalmology, University of Calgary, Calgary, AB, Canada4 aut
7001 a Patel, Praveen J.u NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK4 aut
7001 a Biradar, Mahantesh I.u NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK4 aut
7001 a Sun, Zihanu NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK4 aut
7001 a Chia, Mark A.u NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK4 aut
7001 a Pasquale, Louis R.u Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, NY, USA4 aut
7001 a Wiggs, Janey L.u Department of Ophthalmology, Massachusetts Eye and Ear, Harvard Medical School, Boston, MA, USA4 aut
7001 a Kang, Jae H.u Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA4 aut
7001 a Kim, Jihyeu Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA4 aut
7001 a Aschard, Huguesu Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, MA, USA; Institut Pasteur, Université Paris Cité, Department of Computational Biology, F-75015 Paris, France4 aut
7001 a Tran, Jessica H.u Department of Ophthalmology, Icahn School of Medicine at Mount Sinai, New York, NY, USA4 aut
7001 a Lentjes, Marleen A. H.,d 1974-u Örebro universitet,Institutionen för medicinska vetenskaper4 aut0 (Swepub:oru)mals
7001 a Foster, Paul J.u NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK4 aut
7001 a Khawaja, Anthony P.u NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK4 aut
7001 a The International Glaucoma Genetics Consortium, -4 ctb
7102 a NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UKb NIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK; MRC Epidemiology Unit, University of Cambridge, Cambridge, UK4 org
7730 t Ophthalmology Glaucomad : Elsevierg 6:4, s. 366-379q 6:4<366-379x 2589-4234x 2589-4196
8564 u https://doi.org/10.1016/j.ogla.2022.11.008y Fulltext
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-102644
8564 8u https://doi.org/10.1016/j.ogla.2022.11.008

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