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(WFRF:(Chuang Shu Chun)) pers:(Peeters Petra H. M.)
 

Sökning: (WFRF:(Chuang Shu Chun)) pers:(Peeters Petra H. M.) > Hepatocellular carc...

LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00006435naa a2201069 4500
001oai:DiVA.org:umu-50526
003SwePub
008111213s2011 | |||||||||||000 ||eng|
009oai:lup.lub.lu.se:83af0069-5283-4599-8887-b0eff0850048
009oai:gup.ub.gu.se/161988
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-505262 URI
0247 a https://doi.org/10.1093/jnci/djr3952 DOI
0247 a https://lup.lub.lu.se/record/22002282 URI
0247 a https://gup.ub.gu.se/publication/1619882 URI
040 a (SwePub)umud (SwePub)lud (SwePub)gu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Trichopoulos, Dimitrios4 aut
2451 0a Hepatocellular carcinoma risk factors and disease burden in a European cohort :b a nested case-control study
264 c 2011-10-21
264 1a Oxford :b Oxford University Press,c 2011
338 a print2 rdacarrier
520 a Background: To date, no attempt has been made to systematically determine the apportionment of the hepatocellular carcinoma burden in Europe or North America among established risk factors.Methods: Using data collected from 1992 to 2006, which included 4 409 809 person-years in the European Prospective Investigation into Cancer and nutrition (EPIC), we identified 125 case patients with hepatocellular carcinoma, of whom 115 were matched to 229 control subjects. We calculated odds ratios (ORs) for the association of documented risk factors for hepatocellular carcinoma with incidence of this disease and estimated their importance in this European cohort.Results: Chronic hepatitis B virus (HBV) or hepatitis C virus (HCV) infection (OR = 9.10, 95% confidence interval [CI] = 2.10 to 39.50 and OR = 13.36, 95% CI = 4.11 to 43.45, respectively), obesity (OR = 2.13, 95% CI = 1.06 to 4.29), former or current smoking (OR = 1.98, 95% CI = 0.90 to 4.39 and OR = 4.55, 95% CI = 1.90 to 10.91, respectively), and heavy alcohol intake (OR = 1.77, 95% CI = 0.73 to 4.27) were associated with hepatocellular carcinoma. Smoking contributed to almost half of all hepatocellular carcinomas (47.6%), whereas 13.2% and 20.9% were attributable to chronic HBV and HCV infection, respectively. Obesity and heavy alcohol intake contributed 16.1% and 10.2%, respectively. Almost two-thirds (65.7%, 95% CI = 50.6% to 79.3%) of hepatocellular carcinomas can be accounted for by exposure to at least one of these documented risk factors.Conclusions: Smoking contributed to more hepatocellular carcinomas in this Europe-wide cohort than chronic HBV and HCV infections. Heavy alcohol consumption and obesity also contributed to sizeable fractions of this disease burden. These contributions may be underestimates because EPIC volunteers are likely to be more health conscious than the general population.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaper0 (SwePub)3012 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicine0 (SwePub)3012 hsv//eng
653 a hepatitis-c virus
653 a attributable risk
653 a liver disease
653 a cancer; nutrition
653 a exposure
653 a alcohol
653 a association
653 a population
653 a antibodies
7001 a Bamia, Christina4 aut
7001 a Lagiou, Pagona4 aut
7001 a Fedirko, Veronika4 aut
7001 a Trepo, Elisabeth4 aut
7001 a Jenab, Mazda4 aut
7001 a Pischon, Tobias4 aut
7001 a Noethlings, Ute4 aut
7001 a Overved, Kim4 aut
7001 a Tjonneland, Anne4 aut
7001 a Outzen, Malene4 aut
7001 a Clavel-Chapelon, Francoise4 aut
7001 a Kaaks, Rudolf4 aut
7001 a Lukanova, Annekatrin4 aut
7001 a Boeing, Heiner4 aut
7001 a Aleksandrova, Krasimira4 aut
7001 a Benetou, Vassiliki4 aut
7001 a Zylis, Dimosthenis4 aut
7001 a Palli, Domenico4 aut
7001 a Pala, Valeria4 aut
7001 a Panico, Salvatore4 aut
7001 a Tumino, Rosario4 aut
7001 a Sacerdote, Carlotta4 aut
7001 a Bueno-De-Mesquita, H. Bas4 aut
7001 a Van Kranen, Henk J.4 aut
7001 a Peeters, Petra H. M.4 aut
7001 a Lund, Eiliv4 aut
7001 a Ramon Quiros, J.4 aut
7001 a Gonzalez, Carlos A.4 aut
7001 a Sanchez Perez, Maria-Jose4 aut
7001 a Navarro, Carmen4 aut
7001 a Dorronsoro, Miren4 aut
7001 a Barricarte, Aurelio4 aut
7001 a Lindkvist, Björnu Gothenburg University,Göteborgs universitet,Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups,Institutionen för medicin,Institute of Medicine4 aut0 (Swepub:gu)xlibjo
7001 a Regnér, Sarau Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups4 aut0 (Swepub:lu)kir-sre
7001 a Werner, Mårtenu Umeå universitet,Medicin4 aut0 (Swepub:umu)manwer04
7001 a Hallmans, Göranu Umeå universitet,Näringsforskning4 aut0 (Swepub:umu)goha0001
7001 a Khaw, Kay-Tee4 aut
7001 a Wareham, Nick4 aut
7001 a Key, Timothy4 aut
7001 a Romieu, Isabelle4 aut
7001 a Chuang, Shu-Chun4 aut
7001 a Murphy, Neil4 aut
7001 a Boffetta, Paolo4 aut
7001 a Trichopoulou, Antonia4 aut
7001 a Riboli, Elio4 aut
7102 a Kirurgib Forskargrupper vid Lunds universitet4 org
7730 t Journal of the National Cancer Instituted Oxford : Oxford University Pressg 103:22, s. 1686-1695q 103:22<1686-1695x 0027-8874x 1460-2105
8564 u https://academic.oup.com/jnci/article-pdf/103/22/1686/7673597/djr395.pdf
8564 u http://www.ncbi.nlm.nih.gov/pubmed/22021666?dopt=Abstracty FULLTEXT
8564 u http://dx.doi.org/10.1093/jnci/djr395y FULLTEXT
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-50526
8564 8u https://doi.org/10.1093/jnci/djr395
8564 8u https://lup.lub.lu.se/record/2200228
8564 8u https://gup.ub.gu.se/publication/161988

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