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Dysregulation of Co...
Dysregulation of Complement System and CD4+T Cell Activation Pathways Implicated in Allergic Response
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- Alves, A. C. (författare)
- University of London Imperial Coll Science Technology and Med, England
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- Bruhn, Sören (författare)
- Linköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet
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- Ramasamy, A. (författare)
- University of London Imperial Coll Science Technology and Med, England
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- Wang, Hui (författare)
- Linköpings universitet,Gothenburg University,Göteborgs universitet,Institutionen för kliniska vetenskaper, Avdelningen för pediatrik,Institute of Clinical Sciences, Department of Pediatrics,Avdelningen för kliniska vetenskaper,Hälsouniversitetet
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- Holloway, J. W. (författare)
- University of Southampton, England
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- Hartikainen, A. L. (författare)
- University of Oulu, Finland
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- Jarvelin, M. R. (författare)
- University of London Imperial Coll Science Technology and Med, England
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- Benson, Mikael (författare)
- Linköpings universitet,Avdelningen för kliniska vetenskaper,Hälsouniversitetet
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- Balding, D. J. (författare)
- University of London Imperial Coll Science Technology and Med, England
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- Coin, L. J. M. (författare)
- University of London Imperial Coll Science Technology and Med, England
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(creator_code:org_t)
- 2013-10-08
- 2013
- Engelska.
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Ingår i: Plos One. - : Public Library of Science (PLoS). - 1932-6203. ; 8:10
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https://liu.diva-por... (primary) (Raw object)
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Allergy is a complex disease that is likely to involve dysregulated CD4+ T cell activation. Here we propose a novel methodology to gain insight into how coordinated behaviour emerges between disease-dysregulated pathways in response to pathophysiological stimuli. Using peripheral blood mononuclear cells of allergic rhinitis patients and controls cultured with and without pollen allergens, we integrate CD4+ T cell gene expression from microarray data and genetic markers of allergic sensitisation from GWAS data at the pathway level using enrichment analysis; implicating the complement system in both cellular and systemic response to pollen allergens. We delineate a novel disease network linking T cell activation to the complement system that is significantly enriched for genes exhibiting correlated gene expression and protein-protein interactions, suggesting a tight biological coordination that is dysregulated in the disease state in response to pollen allergen but not to diluent. This novel disease network has high predictive power for the gene and protein expression of the Th2 cytokine profile (IL-4, IL-5, IL-10, IL-13) and of the Th2 master regulator (GATA3), suggesting its involvement in the early stages of CD4+ T cell differentiation. Dissection of the complement system gene expression identifies 7 genes specifically associated with atopic response to pollen, including C1QR1, CFD, CFP, ITGB2, ITGAX and confirms the role of C3AR1 and C5AR1. Two of these genes (ITGB2 and C3AR1) are also implicated in the network linking complement system to T cell activation, which comprises 6 differentially expressed genes. C3AR1 is also significantly associated with allergic sensitisation in GWAS data.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
Nyckelord
- GENOME-WIDE ASSOCIATION
- SET ENRICHMENT ANALYSIS
- NETWORK-BASED
- ANALYSIS
- T-CELLS
- MICROARRAY EXPERIMENTS
- IMMUNE-RESPONSES
- GENE-EXPRESSION
- NASAL-MUCOSA
- RHINITIS
- ASTHMA
- ATES OF AMERICA
- V102
- P15545
- EN A
- 1994
- JOURNAL OF IMMUNOLOGY
- V153
- P1430
- MEDICINE
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Alves, A. C.
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Bruhn, Sören
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Ramasamy, A.
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Wang, Hui
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Holloway, J. W.
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Hartikainen, A. ...
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Jarvelin, M. R.
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Benson, Mikael
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Balding, D. J.
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Coin, L. J. M.
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Göteborgs universitet
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