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Genome-wide meta-an...
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
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Berndt, Sonja I. (author)
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- Gustafsson, Stefan (author)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Science for Life Laboratory, SciLifeLab,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
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Maegi, Reedik (author)
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show more...
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- Ganna, Andrea (author)
- Karolinska Institutet
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Wheeler, Eleanor (author)
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Feitosa, Mary F. (author)
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Justice, Anne E. (author)
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- Lind, Lars (author)
- Uppsala universitet,Kardiovaskulär epidemiologi
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Croteau-Chonka, Damien C. (author)
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Day, Felix R. (author)
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Esko, Tonu (author)
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- Fall, Tove, 1979- (author)
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
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Ferreira, Teresa (author)
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Gentilini, Davide (author)
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Jackson, Anne U. (author)
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Luan, Jian'an (author)
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Randall, Joshua C. (author)
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Vedantam, Sailaja (author)
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Willer, Cristen J. (author)
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Winkler, Thomas W. (author)
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Wood, Andrew R. (author)
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Workalemahu, Tsegaselassie (author)
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Hu, Yi-Juan (author)
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Lee, Sang Hong (author)
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Liang, Liming (author)
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Lin, Dan-Yu (author)
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Min, Josine L. (author)
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Neale, Benjamin M. (author)
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Thorleifsson, Gudmar (author)
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Yang, Jian (author)
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Albrecht, Eva (author)
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Amin, Najaf (author)
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Bragg-Gresham, Jennifer L. (author)
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Cadby, Gemma (author)
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den Heijer, Martin (author)
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Eklund, Niina (author)
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Fischer, Krista (author)
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Goel, Anuj (author)
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Hottenga, Jouke-Jan (author)
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Huffman, Jennifer E. (author)
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Jarick, Ivonne (author)
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- Johansson, Åsa (author)
- Uppsala universitet,Genomik,Uppsala kliniska forskningscentrum (UCR)
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Johnson, Toby (author)
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Kanoni, Stavroula (author)
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Kleber, Marcus E. (author)
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Koenig, Inke R. (author)
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- Kristiansson, Kati (author)
- Karolinska Institutet
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Kutalik, Zoltn (author)
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Lamina, Claudia (author)
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Lecoeur, Cecile (author)
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Li, Guo (author)
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Mangino, Massimo (author)
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McArdle, Wendy L. (author)
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Medina-Gomez, Carolina (author)
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Mueller-Nurasyid, Martina (author)
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Ngwa, Julius S. (author)
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Nolte, Ilja M. (author)
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Paternoster, Lavinia (author)
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Pechlivanis, Sonali (author)
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Perola, Markus (author)
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Peters, Marjolein J. (author)
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Preuss, Michael (author)
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Rose, Lynda M. (author)
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Shi, Jianxin (author)
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- Shungin, Dmitry (author)
- Lund University,Lunds universitet,Umeå universitet,Medicin,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genetisk och molekylär epidemiologi,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Genetic and Molecular Epidemiology
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Smith, Albert Vernon (author)
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- Strawbridge, Rona J. (author)
- Karolinska Institutet
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Surakka, Ida (author)
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Teumer, Alexander (author)
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Trip, Mieke D. (author)
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Tyrer, Jonathan (author)
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Van Vliet-Ostaptchouk, Jana V. (author)
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- Vandenput, Liesbeth, 1974 (author)
- Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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Waite, Lindsay L. (author)
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Zhao, Jing Hua (author)
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Absher, Devin (author)
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Asselbergs, Folkert W. (author)
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Atalay, Mustafa (author)
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Attwood, Antony P. (author)
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Balmforth, Anthony J. (author)
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Basart, Hanneke (author)
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Beilby, John (author)
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Bonnycastle, Lori L. (author)
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Brambilla, Paolo (author)
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Bruinenberg, Marcel (author)
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Campbell, Harry (author)
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Chasman, Daniel I. (author)
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Chines, Peter S. (author)
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Collins, Francis S. (author)
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Connell, John M. (author)
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Cookson, William O. (author)
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- de Faire, Ulf (author)
- Karolinska Institutet
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de Vegt, Femmie (author)
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Dei, Mariano (author)
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Dimitriou, Maria (author)
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Edkins, Sarah (author)
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Estrada, Karol (author)
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Evans, David M. (author)
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Farrall, Martin (author)
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Ferrario, Marco M. (author)
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Ferrieres, Jean (author)
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Franke, Lude (author)
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Frau, Francesca (author)
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Gejman, Pablo V. (author)
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Grallert, Harald (author)
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- Groenberg, Henrik (author)
- Karolinska Institutet
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Gudnason, Vilmundur (author)
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Hall, Alistair S. (author)
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- Hall, Per (author)
- Karolinska Institutet
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Hartikainen, Anna-Liisa (author)
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Hayward, Caroline (author)
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Heard-Costa, Nancy L. (author)
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Heath, Andrew C. (author)
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Hebebrand, Johannes (author)
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Homuth, Georg (author)
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Hu, Frank B. (author)
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Hunt, Sarah E. (author)
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Hyppoenen, Elina (author)
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Iribarren, Carlos (author)
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Jacobs, Kevin B. (author)
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- Jansson, John-Olov, 1954 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för fysiologi,Institute of Neuroscience and Physiology, Department of Physiology
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Jula, Antti (author)
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Kahonen, Mika (author)
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Kathiresan, Sekar (author)
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Kee, Frank (author)
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Khaw, Kay-Tee (author)
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Kivimaki, Mika (author)
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Koenig, Wolfgang (author)
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Kraja, Aldi T. (author)
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Kumari, Meena (author)
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Kuulasmaa, Kari (author)
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Kuusisto, Johanna (author)
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Laitinen, Jaana H. (author)
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Lakka, Timo A. (author)
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Langenberg, Claudia (author)
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Launer, Lenore J. (author)
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Lind, Lars (author)
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Lindstrom, Jaana (author)
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Liu, Jianjun (author)
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Liuzzi, Antonio (author)
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Lokki, Marja-Liisa (author)
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- Lorentzon, Mattias, 1970 (author)
- Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research
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Madden, Pamela A. (author)
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Magnusson, Patrik K. (author)
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Manunta, Paolo (author)
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Marek, Diana (author)
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Maerz, Winfried (author)
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Leach, Irene Mateo (author)
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McKnight, Barbara (author)
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Medland, Sarah E. (author)
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Mihailov, Evelin (author)
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Milani, Lili (author)
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Montgomery, Grant W. (author)
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Mooser, Vincent (author)
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Muehleisen, Thomas W. (author)
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Munroe, Patricia B. (author)
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Musk, Arthur W. (author)
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- Narisu, Narisu (author)
- Karolinska Institutet
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Navis, Gerjan (author)
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Nicholson, George (author)
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Nohr, Ellen A. (author)
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Ong, Ken K. (author)
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Oostra, Ben A. (author)
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Palmer, Colin N. A. (author)
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Palotie, Aarno (author)
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Peden, John F. (author)
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Pedersen, Nancy (author)
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Peters, Annette (author)
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Polasek, Ozren (author)
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Pouta, Anneli (author)
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Pramstaller, Peter P. (author)
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Prokopenko, Inga (author)
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Puetter, Carolin (author)
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Radhakrishnan, Aparna (author)
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Raitakari, Olli (author)
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Rendon, Augusto (author)
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Rivadeneira, Fernando (author)
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Rudan, Igor (author)
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Saaristo, Timo E. (author)
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Sambrook, Jennifer G. (author)
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Sanders, Alan R. (author)
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Sanna, Serena (author)
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Saramies, Jouko (author)
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Schipf, Sabine (author)
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Schreiber, Stefan (author)
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Schunkert, Heribert (author)
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Shin, So-Youn (author)
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Signorini, Stefano (author)
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Sinisalo, Juha (author)
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Skrobek, Boris (author)
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Soranzo, Nicole (author)
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Stancakova, Alena (author)
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Stark, Klaus (author)
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Stephens, Jonathan C. (author)
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Stirrups, Kathleen (author)
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Stolk, Ronald P. (author)
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Stumvoll, Michael (author)
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Swift, Amy J. (author)
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Theodoraki, Eirini V. (author)
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Thorand, Barbara (author)
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Tregouet, David-Alexandre (author)
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Tremoli, Elena (author)
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Van der Klauw, Melanie M. (author)
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van Meurs, Joyce B. J. (author)
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Vermeulen, Sita H. (author)
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Viikari, Jorma (author)
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Virtamo, Jarmo (author)
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Vitart, Veronique (author)
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Waeber, Gerard (author)
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Wang, Zhaoming (author)
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Widen, Elisabeth (author)
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Wild, Sarah H. (author)
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Willemsen, Gonneke (author)
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Winkelmann, Bernhard R. (author)
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Witteman, Jacqueline C. M. (author)
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Wolffenbuttel, Bruce H. R. (author)
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Wong, Andrew (author)
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Wright, Alan F. (author)
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Zillikens, M. Carola (author)
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Amouyel, Philippe (author)
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Boehm, Bernhard O. (author)
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Boerwinkle, Eric (author)
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Boomsma, Dorret I. (author)
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Caulfield, Mark J. (author)
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Chanock, Stephen J. (author)
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Cupples, L. Adrienne (author)
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Cusi, Daniele (author)
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Dedoussis, George V. (author)
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Erdmann, Jeanette (author)
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Eriksson, Johan G. (author)
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- Franks, Paul W. (author)
- Lund University,Lunds universitet,Umeå universitet,Medicin,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genetisk och molekylär epidemiologi,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Genetic and Molecular Epidemiology
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Froguel, Philippe (author)
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Gieger, Christian (author)
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- Gyllensten, Ulf (author)
- Uppsala universitet,Genomik
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- Hamsten, Anders (author)
- Karolinska Institutet
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Harris, Tamara B. (author)
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Hengstenberg, Christian (author)
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Hicks, Andrew A. (author)
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Hingorani, Aroon (author)
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Hinney, Anke (author)
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Hofman, Albert (author)
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Hovingh, Kees G. (author)
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Hveem, Kristian (author)
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Illig, Thomas (author)
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Jarvelin, Marjo-Riitta (author)
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Joeckel, Karl-Heinz (author)
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Keinanen-Kiukaanniemi, Sirkka M. (author)
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Kiemeney, Lambertus A. (author)
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Kuh, Diana (author)
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Laakso, Markku (author)
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Lehtimaki, Terho (author)
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Levinson, Douglas F. (author)
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Martin, Nicholas G. (author)
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Metspalu, Andres (author)
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Morris, Andrew D. (author)
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Nieminen, Markku S. (author)
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Njolstad, Inger (author)
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- Ohlsson, Claes, 1965 (author)
- Gothenburg University,Göteborgs universitet,Centre for Bone and Arthritis Research,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition
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Oldehinkel, Albertine J. (author)
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Ouwehand, Willem H. (author)
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Palmer, Lyle J. (author)
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Penninx, Brenda (author)
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Power, Chris (author)
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Province, Michael A. (author)
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Psaty, Bruce M. (author)
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Qi, Lu (author)
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Rauramaa, Rainer (author)
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Ridker, Paul M. (author)
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Ripatti, Samuli (author)
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Salomaa, Veikko (author)
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Samani, Nilesh J. (author)
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Snieder, Harold (author)
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Sorensen, Thorkild I. A. (author)
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Spector, Timothy D. (author)
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Stefansson, Kari (author)
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Tonjes, Anke (author)
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Tuomilehto, Jaakko (author)
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Uitterlinden, Andre G. (author)
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Uusitupa, Matti (author)
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van der Harst, Pim (author)
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Vollenweider, Peter (author)
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Wallaschofski, Henri (author)
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Wareham, Nicholas J. (author)
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Watkins, Hugh (author)
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Wichmann, H-Erich (author)
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Wilson, James F. (author)
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Abecasis, Goncalo R. (author)
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Assimes, Themistocles L. (author)
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Barroso, Ines (author)
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Boehnke, Michael (author)
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Borecki, Ingrid B. (author)
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Deloukas, Panos (author)
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Fox, Caroline S. (author)
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Frayling, Timothy (author)
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- Groop, Leif (author)
- Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups
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Haritunian, Talin (author)
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Heid, Iris M. (author)
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Hunter, David (author)
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Kaplan, Robert C. (author)
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Karpe, Fredrik (author)
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Moffatt, Miriam F. (author)
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Mohlke, Karen L. (author)
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O'Connell, Jeffrey R. (author)
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- Pawitan, Yudi (author)
- Karolinska Institutet
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Schadt, Eric E. (author)
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Schlessinger, David (author)
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Steinthorsdottir, Valgerdur (author)
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Strachan, David P. (author)
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Thorsteinsdottir, Unnur (author)
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van Duijn, Cornelia M. (author)
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Visscher, Peter M. (author)
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Di Blasio, Anna Maria (author)
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Hirschhorn, Joel N. (author)
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Lindgren, Cecilia M. (author)
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Morris, Andrew P. (author)
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Meyre, David (author)
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Scherag, Andr (author)
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McCarthy, Mark I. (author)
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Speliotes, Elizabeth K. (author)
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North, Kari E. (author)
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Loos, Ruth J. F. (author)
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- Ingelsson, Erik, 1975- (author)
- Uppsala universitet,Science for Life Laboratory, SciLifeLab,Molekylär epidemiologi,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden;Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK;Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, UK
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(creator_code:org_t)
- 2013-04-07
- 2013
- English.
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In: Nature Genetics. - : Springer Science and Business Media LLC. - 1061-4036 .- 1546-1718. ; 45:5, s. 501-U69
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Abstract
Subject headings
Close
- Approaches exploiting trait distribution extremes may be used to identify loci associated with common traits, but it is unknown whether these loci are generalizable to the broader population. In a genome-wide search for loci associated with the upper versus the lower 5th percentiles of body mass index, height and waist-to-hip ratio, as well as clinical classes of obesity, including up to 263,407 individuals of European ancestry, we identified 4 new loci (IGFBP4, H6PD, RSRC1 and PPP2R2A) influencing height detected in the distribution tails and 7 new loci (HNF4G, RPTOR, GNAT2, MRPS33P4, ADCY9, HS6ST3 and ZZZ3) for clinical classes of obesity. Further, we find a large overlap in genetic structure and the distribution of variants between traits based on extremes and the general population and little etiological heterogeneity between obesity subgroups.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Medicinsk genetik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Medical Genetics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Berndt, Sonja I.
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Gustafsson, Stef ...
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Maegi, Reedik
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Ganna, Andrea
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Wheeler, Eleanor
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Feitosa, Mary F.
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show more...
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Justice, Anne E.
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Lind, Lars
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Croteau-Chonka, ...
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Day, Felix R.
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Esko, Tonu
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Fall, Tove, 1979 ...
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Ferreira, Teresa
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Gentilini, David ...
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Jackson, Anne U.
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Luan, Jian'an
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Randall, Joshua ...
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Vedantam, Sailaj ...
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Willer, Cristen ...
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Winkler, Thomas ...
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Wood, Andrew R.
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Workalemahu, Tse ...
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Hu, Yi-Juan
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Lee, Sang Hong
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Liang, Liming
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Lin, Dan-Yu
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Min, Josine L.
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Neale, Benjamin ...
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Thorleifsson, Gu ...
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Yang, Jian
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Albrecht, Eva
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Amin, Najaf
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Bragg-Gresham, J ...
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Cadby, Gemma
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den Heijer, Mart ...
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Eklund, Niina
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Fischer, Krista
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Goel, Anuj
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Hottenga, Jouke- ...
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Huffman, Jennife ...
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Jarick, Ivonne
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Johansson, Åsa
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Johnson, Toby
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Kanoni, Stavroul ...
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Kleber, Marcus E ...
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Koenig, Inke R.
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Kristiansson, Ka ...
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Kutalik, Zoltn
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Lamina, Claudia
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Lecoeur, Cecile
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Li, Guo
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Mangino, Massimo
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McArdle, Wendy L ...
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Medina-Gomez, Ca ...
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Mueller-Nurasyid ...
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Ngwa, Julius S.
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Nolte, Ilja M.
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Paternoster, Lav ...
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Pechlivanis, Son ...
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Perola, Markus
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Peters, Marjolei ...
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Preuss, Michael
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Rose, Lynda M.
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Shi, Jianxin
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Shungin, Dmitry
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Smith, Albert Ve ...
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Strawbridge, Ron ...
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Surakka, Ida
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Teumer, Alexande ...
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Trip, Mieke D.
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Tyrer, Jonathan
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Van Vliet-Ostapt ...
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Vandenput, Liesb ...
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Waite, Lindsay L ...
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Zhao, Jing Hua
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Absher, Devin
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Asselbergs, Folk ...
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Atalay, Mustafa
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Attwood, Antony ...
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Balmforth, Antho ...
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Basart, Hanneke
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Beilby, John
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Bonnycastle, Lor ...
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Brambilla, Paolo
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Bruinenberg, Mar ...
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Campbell, Harry
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Chasman, Daniel ...
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Chines, Peter S.
-
Collins, Francis ...
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Connell, John M.
-
Cookson, William ...
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de Faire, Ulf
-
de Vegt, Femmie
-
Dei, Mariano
-
Dimitriou, Maria
-
Edkins, Sarah
-
Estrada, Karol
-
Evans, David M.
-
Farrall, Martin
-
Ferrario, Marco ...
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Ferrieres, Jean
-
Franke, Lude
-
Frau, Francesca
-
Gejman, Pablo V.
-
Grallert, Harald
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Groenberg, Henri ...
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Gudnason, Vilmun ...
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Hall, Alistair S ...
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Hall, Per
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Hartikainen, Ann ...
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Hayward, Carolin ...
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Heard-Costa, Nan ...
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Heath, Andrew C.
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Hebebrand, Johan ...
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Homuth, Georg
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Hu, Frank B.
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Hunt, Sarah E.
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Hyppoenen, Elina
-
Iribarren, Carlo ...
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Jacobs, Kevin B.
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Jansson, John-Ol ...
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Jula, Antti
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Kahonen, Mika
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Kathiresan, Seka ...
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Kee, Frank
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Khaw, Kay-Tee
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Kivimaki, Mika
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Koenig, Wolfgang
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Kraja, Aldi T.
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Kumari, Meena
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Kuulasmaa, Kari
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Kuusisto, Johann ...
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Laitinen, Jaana ...
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Lakka, Timo A.
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Langenberg, Clau ...
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Launer, Lenore J ...
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Lindstrom, Jaana
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Liu, Jianjun
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Liuzzi, Antonio
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Lokki, Marja-Lii ...
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Lorentzon, Matti ...
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Madden, Pamela A ...
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Magnusson, Patri ...
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Manunta, Paolo
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Marek, Diana
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Maerz, Winfried
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Leach, Irene Mat ...
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McKnight, Barbar ...
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Medland, Sarah E ...
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Mihailov, Evelin
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Milani, Lili
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Montgomery, Gran ...
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Mooser, Vincent
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Muehleisen, Thom ...
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Munroe, Patricia ...
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Musk, Arthur W.
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Narisu, Narisu
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Navis, Gerjan
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Nicholson, Georg ...
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Nohr, Ellen A.
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Ong, Ken K.
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Oostra, Ben A.
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Palmer, Colin N. ...
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Palotie, Aarno
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Peden, John F.
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Pedersen, Nancy
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Peters, Annette
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Polasek, Ozren
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Pouta, Anneli
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Pramstaller, Pet ...
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Prokopenko, Inga
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Puetter, Carolin
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Radhakrishnan, A ...
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Raitakari, Olli
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Rendon, Augusto
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Rivadeneira, Fer ...
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Rudan, Igor
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Saaristo, Timo E ...
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Sambrook, Jennif ...
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Sanders, Alan R.
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Sanna, Serena
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Saramies, Jouko
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Schipf, Sabine
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Schreiber, Stefa ...
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Schunkert, Herib ...
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Shin, So-Youn
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Signorini, Stefa ...
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Sinisalo, Juha
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Skrobek, Boris
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Soranzo, Nicole
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Stancakova, Alen ...
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Stark, Klaus
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Stephens, Jonath ...
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Stirrups, Kathle ...
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Stolk, Ronald P.
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Stumvoll, Michae ...
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Swift, Amy J.
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Theodoraki, Eiri ...
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Thorand, Barbara
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Tregouet, David- ...
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Tremoli, Elena
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Van der Klauw, M ...
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van Meurs, Joyce ...
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Vermeulen, Sita ...
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Viikari, Jorma
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Virtamo, Jarmo
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Vitart, Veroniqu ...
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Waeber, Gerard
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Wang, Zhaoming
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Widen, Elisabeth
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Willemsen, Gonne ...
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Winkelmann, Bern ...
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Witteman, Jacque ...
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Wolffenbuttel, B ...
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Wong, Andrew
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Gyllensten, Ulf
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Hamsten, Anders
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Harris, Tamara B ...
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Hengstenberg, Ch ...
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Hicks, Andrew A.
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Hingorani, Aroon
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Hinney, Anke
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Hofman, Albert
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Hovingh, Kees G.
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Hveem, Kristian
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Metspalu, Andres
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Uusitupa, Matti
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Vollenweider, Pe ...
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Wallaschofski, H ...
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Wareham, Nichola ...
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Watkins, Hugh
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Wilson, James F.
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Assimes, Themist ...
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Barroso, Ines
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Borecki, Ingrid ...
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Deloukas, Panos
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Fox, Caroline S.
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Groop, Leif
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Haritunian, Tali ...
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Heid, Iris M.
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Karpe, Fredrik
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Schlessinger, Da ...
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Steinthorsdottir ...
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Strachan, David ...
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Hirschhorn, Joel ...
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Lindgren, Cecili ...
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Morris, Andrew P ...
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Meyre, David
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Scherag, Andr
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Speliotes, Eliza ...
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North, Kari E.
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Loos, Ruth J. F.
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Ingelsson, Erik, ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Basic Medicine
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and Medical Genetics
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Genetics
- Articles in the publication
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Nature Genetics
- By the university
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Umeå University
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Lund University
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Uppsala University
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Karolinska Institutet
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University of Gothenburg