Reoperation after oesophageal cancer surgery in relation to long-term survival: a population-based cohort study

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Fältnamn	Indikatorer	Metadata
000		03433naa a2200433 4500
001		oai:DiVA.org:umu-102760
003		SwePub
008		150504s2014 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:128643313
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1027602 URI
024	7	a https://doi.org/10.1136/bmjopen-2013-0046482 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1286433132 URI
040		a (SwePub)umud (SwePub)ki
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a van der Schaaf, Maartje4 aut
245	1 0	a Reoperation after oesophageal cancer surgery in relation to long-term survival :b a population-based cohort study
264		c 2014-03-20
264	1	b BMJ,c 2014
338		a print2 rdacarrier
520		a OBJECTIVES: The influence of reoperation on long-term prognosis is unknown. In this large population-based cohort study, it was aimed to investigate the influence of a reoperation within 30 days of oesophageal cancer resection on survival even after excluding the initial postoperative period.DESIGN: This was a nationwide population-based retrospective cohort study.SETTING: All hospitals performing oesophageal cancer resections during the study period (1987-2010) in Sweden.PARTICIPANTS: Patients operated for oesophageal cancer with curative intent in 1987-2010.PRIMARY AND SECONDARY OUTCOMES: Adjusted HRs of all cause, early and late mortality up to 5 years after reoperation following oesophageal cancer resection.RESULTS: Among 1822 included patients, the 200 (11%) who were reoperated had a 27% increased HR of all-cause mortality (adjusted HR 1.27, 95% CI 1.05 to 1.53) and 28% increased HR of disease-specific mortality (adjusted HR 1.28, 95% CI 1.04 to 1.59), compared to those not reoperated. Reoperation for anastomotic insufficiency in particular was followed by an increased mortality (adjusted HR 1.82, 95% CI 1.19 to 2.76).CONCLUSIONS: This large and population-based nationwide cohort study shows that reoperation within 30 days after primary oesophageal resection was associated with increased mortality, even after excluding the initial 3 months after surgery. This finding stresses the need to consider any actions that might prevent complications and reoperation after oesophageal cancer resection.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kirurgi0 (SwePub)302122 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Surgery0 (SwePub)302122 hsv//eng
700	1	a Derogar, Maryamu Karolinska Institutet4 aut
700	1	a Johar, Asifu Karolinska Institutet4 aut
700	1	a Rutegård, Martin,d 1982-u Karolinska Institutet4 aut0 (Swepub:umu)maru0039
700	1	a Gossage, James4 aut
700	1	a Mason, Robert4 aut
700	1	a Lagergren, Pernillau Karolinska Institutet4 aut
700	1	a Lagergren, Jesperu Karolinska Institutet4 aut
710	2	a Karolinska Institutet4 org
773	0	t BMJ Opend : BMJg 4:3q 4:3x 2044-6055
856	4	u https://doi.org/10.1136/bmjopen-2013-004648y Fulltext
856	4	u https://bmjopen.bmj.com/content/4/3/e004648.full.pdf
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-102760
856	4 8	u https://doi.org/10.1136/bmjopen-2013-004648
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:128643313

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Av författaren/redakt...: van der Schaaf, ...; Derogar, Maryam; Johar, Asif; Rutegård, Martin ...; Gossage, James; Mason, Robert; visa fler...; Lagergren, Perni ...; Lagergren, Jespe ...; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Kirurgi

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Av lärosätet: Umeå universitet; Karolinska Institutet

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