Sökning: (WFRF:(Lashley T.)) > A beta efflux impai...
Fältnamn | Indikatorer | Metadata |
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000 | 04054naa a2200745 4500 | |
001 | oai:gup.ub.gu.se/324149 | |
003 | SwePub | |
008 | 240528s2023 | |||||||||||000 ||eng| | |
024 | 7 | a https://gup.ub.gu.se/publication/3241492 URI |
024 | 7 | a https://doi.org/10.1038/s42003-022-04398-22 DOI |
040 | a (SwePub)gu | |
041 | a eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Verma, N.4 aut |
245 | 1 0 | a A beta efflux impairment and inflammation linked to cerebrovascular accumulation of amyloid-forming amylin secreted from pancreas |
264 | c 2023-01-03 | |
264 | 1 | b Springer Science and Business Media LLC,c 2023 |
520 | a Impairment of vascular pathways of cerebral beta-amyloid (A beta) elimination contributes to Alzheimer disease (AD). Vascular damage is commonly associated with diabetes. Here we show in human tissues and AD-model rats that bloodborne islet amyloid polypeptide (amylin) secreted from the pancreas perturbs cerebral A beta clearance. Blood amylin concentrations are higher in AD than in cognitively unaffected persons. Amyloid-forming amylin accumulates in circulating monocytes and co-deposits with A beta within the brain microvasculature, possibly involving inflammation. In rats, pancreatic expression of amyloid-forming human amylin indeed induces cerebrovascular inflammation and amylin-A beta co-deposits. LRP1-mediated A beta transport across the blood-brain barrier and A beta clearance through interstitial fluid drainage along vascular walls are impaired, as indicated by A beta deposition in perivascular spaces. At the molecular level, cerebrovascular amylin deposits alter immune and hypoxia-related brain gene expression. These converging data from humans and laboratory animals suggest that altering bloodborne amylin could potentially reduce cerebrovascular amylin deposits and A beta pathology. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
653 | a alzheimers-disease patients | |
653 | a brain insulin-resistance | |
653 | a il-1-beta | |
653 | a synthesis | |
653 | a polypeptide | |
653 | a cholesterol | |
653 | a mechanisms | |
653 | a clearance | |
653 | a apoptosis | |
653 | a correlate | |
653 | a barrier | |
653 | a Life Sciences & Biomedicine - Other Topics | |
653 | a Science & Technology - Other | |
653 | a Topics | |
700 | 1 | a Velmurugan, G. V.4 aut |
700 | 1 | a Winford, E.4 aut |
700 | 1 | a Coburn, H.4 aut |
700 | 1 | a Kotiya, D.4 aut |
700 | 1 | a Leibold, N.4 aut |
700 | 1 | a Radulescu, L.4 aut |
700 | 1 | a Despa, S.4 aut |
700 | 1 | a Chen, K. C.4 aut |
700 | 1 | a Van Eldik, L. J.4 aut |
700 | 1 | a Nelson, P. T.4 aut |
700 | 1 | a Wilcock, D. M.4 aut |
700 | 1 | a Jicha, G. A.4 aut |
700 | 1 | a Stowe, A. M.4 aut |
700 | 1 | a Goldstein, L. B.4 aut |
700 | 1 | a Powel, D. K.4 aut |
700 | 1 | a Walton, J. H.4 aut |
700 | 1 | a Navedo, M. F.4 aut |
700 | 1 | a Nystoriak, M. A.4 aut |
700 | 1 | a Murray, A. J.4 aut |
700 | 1 | a Biessels, G. J.4 aut |
700 | 1 | a Troakes, C.4 aut |
700 | 1 | a Zetterberg, Henrik,d 1973u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xzethe |
700 | 1 | a Hardy, J.4 aut |
700 | 1 | a Lashley, T.4 aut |
700 | 1 | a Despa, F.4 aut |
710 | 2 | a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi4 org |
773 | 0 | t Communications Biologyd : Springer Science and Business Media LLCg 6:1q 6:1x 2399-3642 |
856 | 4 8 | u https://gup.ub.gu.se/publication/324149 |
856 | 4 8 | u https://doi.org/10.1038/s42003-022-04398-2 |
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