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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04517naa a2200685 4500 | |
| 001 | oai:gup.ub.gu.se/318805 | |
| 003 | SwePub | |
| 008 | 240528s2022 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://gup.ub.gu.se/publication/3188052 URI |
| 024 | 7 | a https://doi.org/10.1161/jaha.121.0254252 DOI |
| 040 | a (SwePub)gu | |
| 041 | a eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Chye, A.4 aut |
| 245 | 1 0 | a Repeated Measures of Modified Rankin Scale Scores to Assess Functional Recovery From Stroke: AFFINITY Study Findings |
| 264 | 1 | b Ovid Technologies (Wolters Kluwer Health),c 2022 |
| 520 | a BACKGROUND: Function after acute stroke using the modified Rankin Scale (mRS) is usually assessed at a point in time. The analytical implications of serial mRS measurements to evaluate functional recovery over time is not completely understood. We compare repeated-measures and single-measure analyses of the mRS from a randomized clinical trial. METHODS AND RESULTS: Serial mRS data from AFFINITY (Assessment of Fluoxetine in Stroke Recovery), a double-blind placebo randomized clinical trial of fluoxetine following stroke (n=1280) were analyzed to identify demographic and clinical associations with functional recovery (reduction in mRS) over 12 months. Associations were identified using single-measure (day 365) and repeated-measures (days 28, 90, 180, and 365) partial proportional odds logistic regression. Ninety-five percent of participants experienced a reduction in mRS after 12 months. Functional recovery was associated with age at stroke <70 years; no prestroke history of diabetes, coronary heart disease, or ischemic stroke; prestroke history of depression, a relationship partner, living with others, independence, or paid employment; no fluoxetine intervention; ischemic stroke (compared with hemorrhagic); stroke treatment in Vietnam (compared with Australia or New Zealand); longer time since current stroke; and lower baseline National Institutes of Health Stroke Scale & Patient Health Questionnaire-9 scores. Direction of associations was largely concordant between single-measure and repeated-measures models. Association strength and variance was generally smaller in the repeated-measures model compared with the single-measure model. CONCLUSIONS: Repeated-measures may improve trial precision in identifying trial associations and effects. Further repeated-measures stroke analyses are required to prove methodological value. | |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kardiologi0 (SwePub)302062 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cardiac and Cardiovascular Systems0 (SwePub)302062 hsv//eng |
| 653 | a cerebrovascular disease | |
| 653 | a functional outcomes | |
| 653 | a modified Rankin Scale | |
| 653 | a partial proportional odds | |
| 653 | a repeated measures | |
| 653 | a stroke | |
| 653 | a ischemic-stroke | |
| 653 | a disability | |
| 653 | a outcomes | |
| 653 | a recommendations | |
| 653 | a rehabilitation | |
| 653 | a association | |
| 653 | a validation | |
| 653 | a prediction | |
| 653 | a trials | |
| 653 | a Cardiovascular System & Cardiology | |
| 700 | 1 | a Hackett, M. L.4 aut |
| 700 | 1 | a Hankey, G. J.4 aut |
| 700 | 1 | a Lundstrom, E.4 aut |
| 700 | 1 | a Almeida, O. P.4 aut |
| 700 | 1 | a Gommans, J.4 aut |
| 700 | 1 | a Dennis, M.4 aut |
| 700 | 1 | a Jan, S.4 aut |
| 700 | 1 | a Mead, G. E.4 aut |
| 700 | 1 | a Ford, A. H.4 aut |
| 700 | 1 | a Beer, C. E.4 aut |
| 700 | 1 | a Flicker, L.4 aut |
| 700 | 1 | a Delcourt, C.4 aut |
| 700 | 1 | a Billot, L.4 aut |
| 700 | 1 | a Anderson, C. S.4 aut |
| 700 | 1 | a Stibrant Sunnerhagen, Katharina,d 1957u Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap,Institute of Neuroscience and Physiology, Department of Clinical Neuroscience4 aut0 (Swepub:gu)xstika |
| 700 | 1 | a Yi, Q. L.4 aut |
| 700 | 1 | a Bompoint, S.4 aut |
| 700 | 1 | a Nguyen, T. H.4 aut |
| 700 | 1 | a Lung, T.4 aut |
| 710 | 2 | a Göteborgs universitetb Institutionen för neurovetenskap och fysiologi, sektionen för klinisk neurovetenskap4 org |
| 773 | 0 | t Journal of the American Heart Association (JAHA)d : Ovid Technologies (Wolters Kluwer Health)g 11:16q 11:16x 2047-9980 |
| 856 | 4 8 | u https://gup.ub.gu.se/publication/318805 |
| 856 | 4 8 | u https://doi.org/10.1161/jaha.121.025425 |
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