Sökning: (WFRF:(Luo Juhua)) > Genetic Variants Re...
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000 | 09079naa a2201777 4500 | |
001 | oai:DiVA.org:uu-337237 | |
003 | SwePub | |
008 | 171221s2017 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:umu-142908 | |
009 | oai:prod.swepub.kib.ki.se:136760620 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3372372 URI |
024 | 7 | a https://doi.org/10.1016/j.eururo.2017.07.0152 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1429082 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1367606202 URI |
040 | a (SwePub)uud (SwePub)umud (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Machiela, Mitchell J4 aut |
245 | 1 0 | a Genetic Variants Related to Longer Telomere Length are Associated with Increased Risk of Renal Cell Carcinoma. |
264 | 1 | b Elsevier BV,c 2017 |
338 | a print2 rdacarrier | |
500 | a Correction in: European Urology, Vol. 74, Issue 3, pages e85-e86DOI: 10.1016/j.eururo.2018.05.017 | |
500 | a Correction to affiliations for authors Lenka Foretova, Ivana Holcatova, Vladimir Janout, Dana Mates, Anush Mukeriya, Stefan Rascu, David Zaridze, Vladimir Bencko, and Cezary Cybulski in a corrected list, DOI: 10.1016/j.eururo.2018.05.017 | |
520 | a BACKGROUND: Relative telomere length in peripheral blood leukocytes has been evaluated as a potential biomarker for renal cell carcinoma (RCC) risk in several studies, with conflicting findings.OBJECTIVE: We performed an analysis of genetic variants associated with leukocyte telomere length to assess the relationship between telomere length and RCC risk using Mendelian randomization, an approach unaffected by biases from temporal variability and reverse causation that might have affected earlier investigations.DESIGN, SETTING, AND PARTICIPANTS: Genotypes from nine telomere length-associated variants for 10 784 cases and 20 406 cancer-free controls from six genome-wide association studies (GWAS) of RCC were aggregated into a weighted genetic risk score (GRS) predictive of leukocyte telomere length.OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: Odds ratios (ORs) relating the GRS and RCC risk were computed in individual GWAS datasets and combined by meta-analysis.RESULTS AND LIMITATIONS: Longer genetically inferred telomere length was associated with an increased risk of RCC (OR=2.07 per predicted kilobase increase, 95% confidence interval [CI]:=1.70-2.53, p<0.0001). As a sensitivity analysis, we excluded two telomere length variants in linkage disequilibrium (R2>0.5) with GWAS-identified RCC risk variants (rs10936599 and rs9420907) from the telomere length GRS; despite this exclusion, a statistically significant association between the GRS and RCC risk persisted (OR=1.73, 95% CI=1.36-2.21, p<0.0001). Exploratory analyses for individual histologic subtypes suggested comparable associations with the telomere length GRS for clear cell (N=5573, OR=1.93, 95% CI=1.50-2.49, p<0.0001), papillary (N=573, OR=1.96, 95% CI=1.01-3.81, p=0.046), and chromophobe RCC (N=203, OR=2.37, 95% CI=0.78-7.17, p=0.13).CONCLUSIONS: Our investigation adds to the growing body of evidence indicating some aspect of longer telomere length is important for RCC risk.PATIENT SUMMARY: Telomeres are segments of DNA at chromosome ends that maintain chromosomal stability. Our study investigated the relationship between genetic variants associated with telomere length and renal cell carcinoma risk. We found evidence suggesting individuals with inherited predisposition to longer telomere length are at increased risk of developing renal cell carcinoma. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Urologi och njurmedicin0 (SwePub)302142 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Urology and Nephrology0 (SwePub)302142 hsv//eng |
653 | a Genetic variants | |
653 | a Mendelian randomization | |
653 | a Renal cell carcinoma | |
653 | a Risk | |
653 | a Telomere length | |
700 | 1 | a Hofmann, Jonathan N4 aut |
700 | 1 | a Carreras-Torres, Robert4 aut |
700 | 1 | a Brown, Kevin M4 aut |
700 | 1 | a Johansson, Mattias4 aut |
700 | 1 | a Wang, Zhaoming4 aut |
700 | 1 | a Foll, Matthieu4 aut |
700 | 1 | a Li, Peng4 aut |
700 | 1 | a Rothman, Nathaniel4 aut |
700 | 1 | a Savage, Sharon A4 aut |
700 | 1 | a Gaborieau, Valerie4 aut |
700 | 1 | a McKay, James D4 aut |
700 | 1 | a Ye, Yuanqing4 aut |
700 | 1 | a Henrion, Marc4 aut |
700 | 1 | a Bruinsma, Fiona4 aut |
700 | 1 | a Jordan, Susan4 aut |
700 | 1 | a Severi, Gianluca4 aut |
700 | 1 | a Hveem, Kristian4 aut |
700 | 1 | a Vatten, Lars J4 aut |
700 | 1 | a Fletcher, Tony4 aut |
700 | 1 | a Koppova, Kvetoslava4 aut |
700 | 1 | a Larsson, Susanna Cu Karolinska Institutet,Uppsala universitet,Ortopedi4 aut0 (Swepub:uu)susla720 |
700 | 1 | a Wolk, Alicjau Karolinska Institutet,Uppsala universitet,Ortopedi4 aut0 (Swepub:uu)alwol516 |
700 | 1 | a Banks, Rosamonde E4 aut |
700 | 1 | a Selby, Peter J4 aut |
700 | 1 | a Easton, Douglas F4 aut |
700 | 1 | a Pharoah, Paul4 aut |
700 | 1 | a Andreotti, Gabriella4 aut |
700 | 1 | a Freeman, Laura E Beane4 aut |
700 | 1 | a Koutros, Stella4 aut |
700 | 1 | a Albanes, Demetrius4 aut |
700 | 1 | a Mannisto, Satu4 aut |
700 | 1 | a Weinstein, Stephanie4 aut |
700 | 1 | a Clark, Peter E4 aut |
700 | 1 | a Edwards, Todd E4 aut |
700 | 1 | a Lipworth, Loren4 aut |
700 | 1 | a Gapstur, Susan M4 aut |
700 | 1 | a Stevens, Victoria L4 aut |
700 | 1 | a Carol, Hallie4 aut |
700 | 1 | a Freedman, Matthew L4 aut |
700 | 1 | a Pomerantz, Mark M4 aut |
700 | 1 | a Cho, Eunyoung4 aut |
700 | 1 | a Kraft, Peter4 aut |
700 | 1 | a Preston, Mark A4 aut |
700 | 1 | a Wilson, Kathryn M4 aut |
700 | 1 | a Gaziano, J Michael4 aut |
700 | 1 | a Sesso, Howard S4 aut |
700 | 1 | a Black, Amanda4 aut |
700 | 1 | a Freedman, Neal D4 aut |
700 | 1 | a Huang, Wen-Yi4 aut |
700 | 1 | a Anema, John G4 aut |
700 | 1 | a Kahnoski, Richard J4 aut |
700 | 1 | a Lane, Brian R4 aut |
700 | 1 | a Noyes, Sabrina L4 aut |
700 | 1 | a Petillo, David4 aut |
700 | 1 | a Colli, Leandro M4 aut |
700 | 1 | a Sampson, Joshua N4 aut |
700 | 1 | a Besse, Celine4 aut |
700 | 1 | a Blanche, Helene4 aut |
700 | 1 | a Boland, Anne4 aut |
700 | 1 | a Burdette, Laurie4 aut |
700 | 1 | a Prokhortchouk, Egor4 aut |
700 | 1 | a Skryabin, Konstantin G4 aut |
700 | 1 | a Yeager, Meredith4 aut |
700 | 1 | a Mijuskovic, Mirjana4 aut |
700 | 1 | a Ognjanovic, Miodrag4 aut |
700 | 1 | a Foretova, Lenka4 aut |
700 | 1 | a Holcatova, Ivana4 aut |
700 | 1 | a Janout, Vladimir4 aut |
700 | 1 | a Mates, Dana4 aut |
700 | 1 | a Mukeriya, Anush4 aut |
700 | 1 | a Rascu, Stefan4 aut |
700 | 1 | a Zaridze, David4 aut |
700 | 1 | a Bencko, Vladimir4 aut |
700 | 1 | a Cybulski, Cezary4 aut |
700 | 1 | a Fabianova, Eleonora4 aut |
700 | 1 | a Jinga, Viorel4 aut |
700 | 1 | a Lissowska, Jolanta4 aut |
700 | 1 | a Lubinski, Jan4 aut |
700 | 1 | a Navratilova, Marie4 aut |
700 | 1 | a Rudnai, Peter4 aut |
700 | 1 | a Szeszenia-Dabrowska, Neonila4 aut |
700 | 1 | a Benhamou, Simone4 aut |
700 | 1 | a Cancel-Tassin, Geraldine4 aut |
700 | 1 | a Cussenot, Olivier4 aut |
700 | 1 | a Bueno-de-Mesquita, H Bas4 aut |
700 | 1 | a Canzian, Federico4 aut |
700 | 1 | a Duell, Eric J4 aut |
700 | 1 | a Ljungberg, Börjeu Umeå universitet,Urologi och andrologi4 aut0 (Swepub:umu)bolj0001 |
700 | 1 | a Sitaram, Raviprakash T.u Umeå universitet,Urologi och andrologi4 aut0 (Swepub:umu)tura0001 |
700 | 1 | a Peters, Ulrike4 aut |
700 | 1 | a White, Emily4 aut |
700 | 1 | a Anderson, Garnet L4 aut |
700 | 1 | a Johnson, Lisa4 aut |
700 | 1 | a Luo, Juhua4 aut |
700 | 1 | a Buring, Julie4 aut |
700 | 1 | a Lee, I-Min4 aut |
700 | 1 | a Chow, Wong-Ho4 aut |
700 | 1 | a Moore, Lee E4 aut |
700 | 1 | a Wood, Christopher4 aut |
700 | 1 | a Eisen, Timothy4 aut |
700 | 1 | a Larkin, James4 aut |
700 | 1 | a Choueiri, Toni K4 aut |
700 | 1 | a Lathrop, G Mark4 aut |
700 | 1 | a Teh, Bin Tean4 aut |
700 | 1 | a Deleuze, Jean-Francois4 aut |
700 | 1 | a Wu, Xifeng4 aut |
700 | 1 | a Houlston, Richard S4 aut |
700 | 1 | a Brennan, Paul4 aut |
700 | 1 | a Chanock, Stephen J4 aut |
700 | 1 | a Scelo, Ghislaine4 aut |
700 | 1 | a Purdue, Mark P4 aut |
710 | 2 | a Uppsala universitetb Ortopedi4 org |
773 | 0 | t European Urologyd : Elsevier BVg 72:5, s. 747-754q 72:5<747-754x 0302-2838x 1873-7560 |
856 | 4 | u http://eprints.whiterose.ac.uk/119343/26/Supplementary%20Materials_Revision3_clean.pdf |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-337237 |
856 | 4 8 | u https://doi.org/10.1016/j.eururo.2017.07.015 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-142908 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:136760620 |
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