Sökning: (WFRF:(Meng J)) srt2:(2015-2019)
> (2015) >
Endocrine-Disruptin...
Endocrine-Disrupting Activity of Hydraulic Fracturing Chemicals and Adverse Health Outcomes After Prenatal Exposure in Male Mice
-
- Kassotis, Christopher D. (författare)
- Nicholas School of the Environment, Duke University, Durham, USA
-
- Klemp, Kara C. (författare)
- Department of Obstetrics, Gynecology, and Women's Health, University of Missouri, Columbia, USA
-
- Vu, Danh C. (författare)
- Department of Forestry, University of Missouri, Columbia, USA
-
visa fler...
-
- Lin, Chung-Ho (författare)
- Department of Forestry, University of Missouri, Columbia, USA
-
- Meng, Chun-Xia (författare)
- Department of Obstetrics, Gynecology, and Women's Health, University of Missouri, Columbia, USA
-
- Besch-Williford, Cynthia L. (författare)
- IDEXX RADIL Pathology Services, Columbia, USA
-
- Pinatti, Lisa (författare)
- Department of Biology, University of Massachusetts, Amherst, USA
-
- Zoeller, R. Thomas, 1952- (författare)
- Department of Biology, University of Massachusetts, Amherst, USA
-
- Drobnis, Erma Z. (författare)
- Department of Obstetrics, Gynecology, and Women's Health, University of Missouri, Columbia, USA
-
- Balise, Victoria D. (författare)
- Department of Obstetrics, Gynecology, and Women's Health, University of Missouri, Columbia, USA; Division of Biological Sciences, University of Missouri, Columbia, USA
-
- Isiguzo, Chiamaka J. (författare)
- Department of Obstetrics, Gynecology, and Women's Health, University of Missouri, Columbia, USA
-
- Williams, Michelle A. (författare)
- Division of Biological Sciences, University of Missouri, Columbia, USA
-
- Tillitt, Donald E. (författare)
- US Geological Survey, Columbia Environmental Research Center, Columbia, USA
-
- Nagel, Susan C. (författare)
- Department of Obstetrics, Gynecology, and Women's Health, University of Missouri, Columbia, USA; Division of Biological Sciences, University of Missouri, Columbia, USA
-
visa färre...
-
(creator_code:org_t)
- 2015-10-14
- 2015
- Engelska.
-
Ingår i: Endocrinology. - : Oxford University Press. - 0013-7227 .- 1945-7170. ; 156:12, s. 4458-4473
- Relaterad länk:
-
https://doi.org/10.1...
-
visa fler...
-
https://academic.oup...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Oil and natural gas operations have been shown to contaminate surface and ground water with endocrine-disrupting chemicals. In the current study, we fill several gaps in our understanding of the potential environmental impacts related to this process. We measured the endocrine-disrupting activities of 24 chemicals used and/or produced by oil and gas operations for five nuclear receptors using a reporter gene assay in human endometrial cancer cells. We also quantified the concentration of 16 of these chemicals in oil and gas wastewater samples. Finally, we assessed reproductive and developmental outcomes in male C57BL/6J mice after the prenatal exposure to a mixture of these chemicals. We found that 23 commonly used oil and natural gas operation chemicals can activate or inhibit the estrogen, androgen, glucocorticoid, progesterone, and/or thyroid receptors, and mixtures of these chemicals can behave synergistically, additively, or antagonistically in vitro. Prenatal exposure to a mixture of 23 oil and gas operation chemicals at 3, 30, and 300 μg/kg · d caused decreased sperm counts and increased testes, body, heart, and thymus weights and increased serum testosterone in male mice, suggesting multiple organ system impacts. Our results suggest possible adverse developmental and reproductive health outcomes in humans and animals exposed to potential environmentally relevant levels of oil and gas operation chemicals.
Ämnesord
- NATURVETENSKAP -- Geovetenskap och miljövetenskap -- Miljövetenskap (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences -- Environmental Sciences (hsv//eng)
Nyckelord
- Enviromental Science
- Miljövetenskap
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Kassotis, Christ ...
-
Klemp, Kara C.
-
Vu, Danh C.
-
Lin, Chung-Ho
-
Meng, Chun-Xia
-
Besch-Williford, ...
-
visa fler...
-
Pinatti, Lisa
-
Zoeller, R. Thom ...
-
Drobnis, Erma Z.
-
Balise, Victoria ...
-
Isiguzo, Chiamak ...
-
Williams, Michel ...
-
Tillitt, Donald ...
-
Nagel, Susan C.
-
visa färre...
- Om ämnet
-
- NATURVETENSKAP
-
NATURVETENSKAP
-
och Geovetenskap och ...
-
och Miljövetenskap
- Artiklar i publikationen
-
Endocrinology
- Av lärosätet
-
Örebro universitet