Search: (WFRF:(Murray Elizabeth)) lar1:(ki) spr:eng >
The association bet...
The association between familial risk and brain abnormalities is disease specific : an ENIGMA-relatives study of schizophrenia and bipolar disorder
-
de Zwarte, Sonja M. C. (author)
-
Brouwer, Rachel M. (author)
-
- Agartz, Ingrid (author)
- Karolinska Institutet
-
show more...
-
Alda, Martin (author)
-
Aleman, André (author)
-
Alpert, Kathryn I. (author)
-
Bearden, Carrie E. (author)
-
Bertolino, Alessandro (author)
-
Bois, Catherine (author)
-
Bonvino, Aurora (author)
-
Bramon, Elvira (author)
-
Buimer, Elizabeth E. L. (author)
-
Cahn, Wiepke (author)
-
Cannon, Dara M. (author)
-
Cannon, Tyrone D. (author)
-
Caseras, Xavier (author)
-
Castro-Fornieles, Josefina (author)
-
Chen, Qiang (author)
-
Chung, Yoonho (author)
-
De la Serna, Elena (author)
-
Di Giorgio, Annabella (author)
-
Doucet, Gaelle E. (author)
-
Eker, Mehmet Cagdas (author)
-
Erk, Susanne (author)
-
Fears, Scott C. (author)
-
Foley, Sonya F. (author)
-
Frangou, Sophia (author)
-
Frankland, Andrew (author)
-
Fullerton, Janice M. (author)
-
Glahn, David C. (author)
-
Goghari, Vina M. (author)
-
Goldman, Aaron L. (author)
-
Gonul, Ali Saffet (author)
-
Gruber, Oliver (author)
-
de Haan, Lieuwe (author)
-
Hajek, Tomas (author)
-
Hawkins, Emma L. (author)
-
Heinz, Andreas (author)
-
Hillegers, Manon H. J. (author)
-
Hulshoff Pol, Hilleke E. (author)
-
Hultman, Christina M. (author)
-
- Ingvar, Martin (author)
- Karolinska Institutet
-
- Johansson, Viktoria (author)
- Karolinska Institutet
-
- Jönsson, Erik G. (author)
- Karolinska Institutet
-
Kane, Fergus (author)
-
Kempton, Matthew J. (author)
-
Koenis, Marinka M. G. (author)
-
Kopecek, Miloslav (author)
-
Krabbendam, Lydia (author)
-
Krämer, Bernd (author)
-
Lawrie, Stephen M. (author)
-
Lenroot, Rhoshel K. (author)
-
Marcelis, Machteld (author)
-
Marsman, Jan-Bernard C. (author)
-
Mattay, Venkata S. (author)
-
McDonald, Colm (author)
-
Meyer-Lindenberg, Andreas (author)
-
Michielse, Stijn (author)
-
Mitchell, Philip B. (author)
-
Moreno, Dolores (author)
-
Murray, Robin M. (author)
-
Mwangi, Benson (author)
-
Najt, Pablo (author)
-
Neilson, Emma (author)
-
Newport, Jason (author)
-
van Os, Jim (author)
-
Overs, Bronwyn (author)
-
Ozerdem, Aysegul (author)
-
Picchioni, Marco M. (author)
-
Richter, Anja (author)
-
Roberts, Gloria (author)
-
Aydogan, Aybala Saricicek (author)
-
Schofield, Peter R. (author)
-
Simsek, Fatma (author)
-
Soares, Jair C. (author)
-
Sugranyes, Gisela (author)
-
Toulopoulou, Timothea (author)
-
Tronchin, Giulia (author)
-
Walter, Henrik (author)
-
Wang, Lei (author)
-
Weinberger, Daniel R. (author)
-
Whalley, Heather C. (author)
-
Yalin, Nefize (author)
-
Andreassen, Ole A. (author)
-
Ching, Christopher R. K. (author)
-
van Erp, Theo G. M. (author)
-
Turner, Jessica A. (author)
-
Jahanshad, Neda (author)
-
Thompson, Paul M. (author)
-
Kahn, René S. (author)
-
van Haren, Neeltje E. M. (author)
-
show less...
-
(creator_code:org_t)
- Elsevier, 2019
- 2019
- English.
-
In: Biological Psychiatry. - : Elsevier. - 0006-3223 .- 1873-2402. ; 86:7, s. 545-556
- Related links:
-
https://doi.org/10.1...
-
show more...
-
https://umu.diva-por... (primary) (Raw object)
-
http://www.biologica...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- BACKGROUND: Schizophrenia and bipolar disorder share genetic liability, and some structural brain abnormalities are common to both conditions. First-degree relatives of patients with schizophrenia (FDRs-SZ) show similar brain abnormalities to patients, albeit with smaller effect sizes. Imaging findings in first-degree relatives of patients with bipolar disorder (FDRs-BD) have been inconsistent in the past, but recent studies report regionally greater volumes compared with control subjects.METHODS: We performed a meta-analysis of global and subcortical brain measures of 6008 individuals (1228 FDRs-SZ, 852 FDRs-BD, 2246 control subjects, 1016 patients with schizophrenia, 666 patients with bipolar disorder) from 34 schizophrenia and/or bipolar disorder family cohorts with standardized methods. Analyses were repeated with a correction for intracranial volume (ICV) and for the presence of any psychopathology in the relatives and control subjects.RESULTS: FDRs-BD had significantly larger ICV (d = +0.16, q < .05 corrected), whereas FDRs-SZ showed smaller thalamic volumes than control subjects (d = -0.12, q < .05 corrected). ICV explained the enlargements in the brain measures in FDRs-BD. In FDRs-SZ, after correction for ICV, total brain, cortical gray matter, cerebral white matter, cerebellar gray and white matter, and thalamus volumes were significantly smaller; the cortex was thinner (d < -0.09, q < .05 corrected); and third ventricle was larger (d = +0.15, q < .05 corrected). The findings were not explained by psychopathology in the relatives or control subjects.CONCLUSIONS: Despite shared genetic liability, FDRs-SZ and FDRs-BD show a differential pattern of structural brain abnormalities, specifically a divergent effect in ICV. This may imply that the neurodevelopmental trajectories leading to brain anomalies in schizophrenia or bipolar disorder are distinct.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Bipolar disorder
- Familial risk
- Imaging
- Meta-analysis
- Neurodevelopment
- Schizophrenia
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
de Zwarte, Sonja ...
-
Brouwer, Rachel ...
-
Agartz, Ingrid
-
Alda, Martin
-
Aleman, André
-
Alpert, Kathryn ...
-
show more...
-
Bearden, Carrie ...
-
Bertolino, Aless ...
-
Bois, Catherine
-
Bonvino, Aurora
-
Bramon, Elvira
-
Buimer, Elizabet ...
-
Cahn, Wiepke
-
Cannon, Dara M.
-
Cannon, Tyrone D ...
-
Caseras, Xavier
-
Castro-Fornieles ...
-
Chen, Qiang
-
Chung, Yoonho
-
De la Serna, Ele ...
-
Di Giorgio, Anna ...
-
Doucet, Gaelle E ...
-
Eker, Mehmet Cag ...
-
Erk, Susanne
-
Fears, Scott C.
-
Foley, Sonya F.
-
Frangou, Sophia
-
Frankland, Andre ...
-
Fullerton, Janic ...
-
Glahn, David C.
-
Goghari, Vina M.
-
Goldman, Aaron L ...
-
Gonul, Ali Saffe ...
-
Gruber, Oliver
-
de Haan, Lieuwe
-
Hajek, Tomas
-
Hawkins, Emma L.
-
Heinz, Andreas
-
Hillegers, Manon ...
-
Hulshoff Pol, Hi ...
-
Hultman, Christi ...
-
Ingvar, Martin
-
Johansson, Vikto ...
-
Jönsson, Erik G.
-
Kane, Fergus
-
Kempton, Matthew ...
-
Koenis, Marinka ...
-
Kopecek, Milosla ...
-
Krabbendam, Lydi ...
-
Krämer, Bernd
-
Lawrie, Stephen ...
-
Lenroot, Rhoshel ...
-
Marcelis, Machte ...
-
Marsman, Jan-Ber ...
-
Mattay, Venkata ...
-
McDonald, Colm
-
Meyer-Lindenberg ...
-
Michielse, Stijn
-
Mitchell, Philip ...
-
Moreno, Dolores
-
Murray, Robin M.
-
Mwangi, Benson
-
Najt, Pablo
-
Neilson, Emma
-
Newport, Jason
-
van Os, Jim
-
Overs, Bronwyn
-
Ozerdem, Aysegul
-
Picchioni, Marco ...
-
Richter, Anja
-
Roberts, Gloria
-
Aydogan, Aybala ...
-
Schofield, Peter ...
-
Simsek, Fatma
-
Soares, Jair C.
-
Sugranyes, Gisel ...
-
Toulopoulou, Tim ...
-
Tronchin, Giulia
-
Walter, Henrik
-
Wang, Lei
-
Weinberger, Dani ...
-
Whalley, Heather ...
-
Yalin, Nefize
-
Andreassen, Ole ...
-
Ching, Christoph ...
-
van Erp, Theo G. ...
-
Turner, Jessica ...
-
Jahanshad, Neda
-
Thompson, Paul M ...
-
Kahn, René S.
-
van Haren, Neelt ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Psychiatry
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Basic Medicine
-
and Neurosciences
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Neurology
- Articles in the publication
-
Biological Psych ...
- By the university
-
Umeå University
-
Karolinska Institutet