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Reduced functional ...
Reduced functional brain activity response in cognitively intact apolipoprotein E ε4 carriers
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- Lind, Johanna (författare)
- Karolinska Institutet
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- Persson, Jonas, 1971- (författare)
- Umeå universitet,Institutionen för psykologi
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- Ingvar, Martin (författare)
- Karolinska Institutet
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- Larsson, Anne (författare)
- Umeå universitet,Radiofysik
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- Cruts, Marc (författare)
- Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology, University of Antwerp, Antwerpen, Belgium
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- Van Broeckhoven, Christine (författare)
- Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology, University of Antwerp, Antwerpen, Belgium
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- Adolfsson, Rolf (författare)
- Umeå universitet,Psykiatri
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- Bäckman, Lars (författare)
- Karolinska Institutet
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- Nilsson, Lars-Göran (författare)
- Stockholms universitet,Psykologiska institutionen
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- Petersson, Karl Magnus (författare)
- Karolinska Institutet
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- Nyberg, Lars, 1966- (författare)
- Umeå universitet,Institutionen för psykologi
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(creator_code:org_t)
- 2006-03-14
- 2006
- Engelska.
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Ingår i: Brain. - : Oxford University Press. - 0006-8950 .- 1460-2156. ; 129:5, s. 1240-1248
- Relaterad länk:
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https://academic.oup...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- The apolipoprotein E epsilon4 (APOE epsilon4) is the main known genetic risk factor for Alzheimer's disease. Genetic assessments in combination with other diagnostic tools, such as neuroimaging, have the potential to facilitate early diagnosis. In this large-scale functional MRI (fMRI) study, we have contrasted 30 APOE epsilon4 carriers (age range: 49-74 years; 19 females), of which 10 were homozygous for the epsilon4 allele, and 30 non-carriers with regard to brain activity during a semantic categorization task. Test groups were closely matched for sex, age and education. Critically, both groups were cognitively intact and thus symptom-free of Alzheimer's disease. APOE epsilon4 carriers showed reduced task-related responses in the left inferior parietal cortex, and bilaterally in the anterior cingulate region. A dose-related response was observed in the parietal area such that diminution was most pronounced in homozygous compared with heterozygous carriers. In addition, contrasts of processing novel versus familiar items revealed an abnormal response in the right hippocampus in the APOE epsilon4 group, mainly expressed as diminished sensitivity to the relative novelty of stimuli. Collectively, these findings indicate that genetic risk translates into reduced functional brain activity, in regions pertinent to Alzheimer's disease, well before alterations can be detected at the behavioural level.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
- SAMHÄLLSVETENSKAP -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology (hsv//eng)
Nyckelord
- MEDICINE
- MEDICIN
- medicin
- Medicine
- apolipoprotein E
- Psychology
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Brain
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Till lärosätets databas
- Av författaren/redakt...
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Lind, Johanna
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Persson, Jonas, ...
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Ingvar, Martin
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Larsson, Anne
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Cruts, Marc
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Van Broeckhoven, ...
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Adolfsson, Rolf
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Bäckman, Lars
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Nilsson, Lars-Gö ...
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Petersson, Karl ...
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Nyberg, Lars, 19 ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Psykiatri
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- SAMHÄLLSVETENSKAP
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SAMHÄLLSVETENSKA ...
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och Psykologi
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Brain
- Av lärosätet
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Umeå universitet
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Karolinska Institutet
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Stockholms universitet