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Global phylogeography and ancient evolution of the widespread human gut virus crAssphage

Edwards, Robert A. (author)
Vega, Alejandro A. (author)
Norman, Holly M. (author)
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Ohaeri, Maria (author)
Levi, Kyle (author)
Dinsdale, Elizabeth A. (author)
Cinek, Ondrej (author)
Aziz, Ramy K. (author)
McNair, Katelyn (author)
Barr, Jeremy J. (author)
Bibby, Kyle (author)
Brouns, Stan J. J. (author)
Cazares, Adrian (author)
de Jonge, Patrick A. (author)
Desnues, Christelle (author)
Diaz Munoz, Samuel L. (author)
Fineran, Peter C. (author)
Kurilshikov, Alexander (author)
Lavigne, Rob (author)
Mazankova, Karla (author)
McCarthy, David T. (author)
Nobrega, Franklin L. (author)
Reyes Munoz, Alejandro (author)
Tapia, German (author)
Trefault, Nicole (author)
Tyakht, Alexander (author)
Vinuesa, Pablo (author)
Wagemans, Jeroen (author)
Zhernakova, Alexandra (author)
Aarestrup, Frank M. (author)
Ahmadov, Gunduz (author)
Alassaf, Abeer (author)
Anton, Josefa (author)
Asangba, Abigail (author)
Billings, Emma K. (author)
Cantu, Vito Adrian (author)
Carlton, Jane M. (author)
Cazares, Daniel (author)
Cho, Gyu-Sung (author)
Condeff, Tess (author)
Cortes, Pilar (author)
Cranfield, Mike (author)
Cuevas, Daniel A. (author)
De la Iglesia, Rodrigo (author)
Decewicz, Przemyslaw (author)
Doane, Michael P. (author)
Dominy, Nathaniel J. (author)
Dziewit, Lukasz (author)
Elwasila, Bashir Mukhtar (author)
Murat Eren, A. (author)
Franz, Charles (author)
Fu, Jingyuan (author)
Garcia-Aljaro, Cristina (author)
Ghedin, Elodie (author)
Gulino, Kristen M. (author)
Haggerty, John M. (author)
Head, Steven R. (author)
Hendriksen, Rene S. (author)
Hill, Colin (author)
Hyoty, Heikki (author)
Ilina, Elena N. (author)
Irwin, Mitchell T. (author)
Jeffries, Thomas C. (author)
Jofre, Juan (author)
Junge, Randall E. (author)
Kelley, Scott T. (author)
Mirzaei, Mohammadali Khan (author)
Kowalewski, Martin (author)
Kumaresan, Deepak (author)
Leigh, Steven R. (author)
Lipson, David (author)
Lisitsyna, Eugenia S. (author)
Llagostera, Montserrat (author)
Maritz, Julia M. (author)
Marr, Linsey C. (author)
McCann, Angela (author)
Molshanski-Mor, Shahar (author)
Monteiro, Silvia (author)
Moreira-Grez, Benjamin (author)
Morris, Megan (author)
Mugisha, Lawrence (author)
Muniesa, Maite (author)
Neve, Horst (author)
Nam-phuong, Nguyen (author)
Nigro, Olivia D. (author)
Nilsson, Anders S. (author)
Stockholms universitet,Institutionen för molekylär biovetenskap, Wenner-Grens institut
O'Connell, Taylor (author)
Odeh, Rasha (author)
Oliver, Andrew (author)
Piuri, Mariana (author)
Prussin, Aaron J. (author)
Qimron, Udi (author)
Quan, Zhe-Xue (author)
Rainetova, Petra (author)
Ramirez-Rojas, Adan (author)
Raya, Raul (author)
Reasor, Kim (author)
Rice, Gillian A. O. (author)
Rossi, Alessandro (author)
Santos, Ricardo (author)
Shimashita, John (author)
Stachler, Elyse N. (author)
Stene, Lars C. (author)
Strain, Ronan (author)
Stumpf, Rebecca (author)
Torres, Pedro J. (author)
Twaddle, Alan (author)
Ibekwe, MaryAnn Ugochi (author)
Villagra, Nicolas (author)
Wandro, Stephen (author)
White, Bryan (author)
Whiteley, Andy (author)
Whiteson, Katrine L. (author)
Wijmenga, Cisca (author)
Zambrano, Maria M. (author)
Zschach, Henrike (author)
Dutilh, Bas E. (author)
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 (creator_code:org_t)
2019-07-08
2019
English.
In: Nature Microbiology. - : Springer Science and Business Media LLC. - 2058-5276. ; 4:10, s. 1727-1736
  • Journal article (peer-reviewed)
Abstract Subject headings
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  • Microbiomes are vast communities of microorganisms and viruses that populate all natural ecosystems. Viruses have been considered to be the most variable component of microbiomes, as supported by virome surveys and examples of high genomic mosaicism. However, recent evidence suggests that the human gut virome is remarkably stable compared with that of other environments. Here, we investigate the origin, evolution and epidemiology of crAssphage, a widespread human gut virus. Through a global collaboration, we obtained DNA sequences of crAssphage from more than one-third of the world's countries and showed that the phylogeography of crAssphage is locally clustered within countries, cities and individuals. We also found fully colinear crAssphage-like genomes in both Old-World and New-World primates, suggesting that the association of crAssphage with primates may be millions of years old. Finally, by exploiting a large cohort of more than 1,000 individuals, we tested whether crAssphage is associated with bacterial taxonomic groups of the gut microbiome, diverse human health parameters and a wide range of dietary factors. We identified strong correlations with different clades of bacteria that are related to Bacteroidetes and weak associations with several diet categories, but no significant association with health or disease. We conclude that crAssphage is a benign cosmopolitan virus that may have coevolved with the human lineage and is an integral part of the normal human gut virome.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Microbiology in the medical area (hsv//eng)

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By the author/editor
Edwards, Robert ...
Vega, Alejandro ...
Norman, Holly M.
Ohaeri, Maria
Levi, Kyle
Dinsdale, Elizab ...
show more...
Cinek, Ondrej
Aziz, Ramy K.
McNair, Katelyn
Barr, Jeremy J.
Bibby, Kyle
Brouns, Stan J. ...
Cazares, Adrian
de Jonge, Patric ...
Desnues, Christe ...
Diaz Munoz, Samu ...
Fineran, Peter C ...
Kurilshikov, Ale ...
Lavigne, Rob
Mazankova, Karla
McCarthy, David ...
Nobrega, Frankli ...
Reyes Munoz, Ale ...
Tapia, German
Trefault, Nicole
Tyakht, Alexande ...
Vinuesa, Pablo
Wagemans, Jeroen
Zhernakova, Alex ...
Aarestrup, Frank ...
Ahmadov, Gunduz
Alassaf, Abeer
Anton, Josefa
Asangba, Abigail
Billings, Emma K ...
Cantu, Vito Adri ...
Carlton, Jane M.
Cazares, Daniel
Cho, Gyu-Sung
Condeff, Tess
Cortes, Pilar
Cranfield, Mike
Cuevas, Daniel A ...
De la Iglesia, R ...
Decewicz, Przemy ...
Doane, Michael P ...
Dominy, Nathanie ...
Dziewit, Lukasz
Elwasila, Bashir ...
Murat Eren, A.
Franz, Charles
Fu, Jingyuan
Garcia-Aljaro, C ...
Ghedin, Elodie
Gulino, Kristen ...
Haggerty, John M ...
Head, Steven R.
Hendriksen, Rene ...
Hill, Colin
Hyoty, Heikki
Ilina, Elena N.
Irwin, Mitchell ...
Jeffries, Thomas ...
Jofre, Juan
Junge, Randall E ...
Kelley, Scott T.
Mirzaei, Mohamma ...
Kowalewski, Mart ...
Kumaresan, Deepa ...
Leigh, Steven R.
Lipson, David
Lisitsyna, Eugen ...
Llagostera, Mont ...
Maritz, Julia M.
Marr, Linsey C.
McCann, Angela
Molshanski-Mor, ...
Monteiro, Silvia
Moreira-Grez, Be ...
Morris, Megan
Mugisha, Lawrenc ...
Muniesa, Maite
Neve, Horst
Nam-phuong, Nguy ...
Nigro, Olivia D.
Nilsson, Anders ...
O'Connell, Taylo ...
Odeh, Rasha
Oliver, Andrew
Piuri, Mariana
Prussin, Aaron J ...
Qimron, Udi
Quan, Zhe-Xue
Rainetova, Petra
Ramirez-Rojas, A ...
Raya, Raul
Reasor, Kim
Rice, Gillian A. ...
Rossi, Alessandr ...
Santos, Ricardo
Shimashita, John
Stachler, Elyse ...
Stene, Lars C.
Strain, Ronan
Stumpf, Rebecca
Torres, Pedro J.
Twaddle, Alan
Ibekwe, MaryAnn ...
Villagra, Nicola ...
Wandro, Stephen
White, Bryan
Whiteley, Andy
Whiteson, Katrin ...
Wijmenga, Cisca
Zambrano, Maria ...
Zschach, Henrike
Dutilh, Bas E.
show less...
About the subject
MEDICAL AND HEALTH SCIENCES
MEDICAL AND HEAL ...
and Basic Medicine
and Microbiology in ...
Articles in the publication
Nature Microbiol ...
By the university
Stockholm University

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