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FältnamnIndikatorerMetadata
00004914naa a2200481 4500
001oai:DiVA.org:umu-220858
003SwePub
008240219s2023 | |||||||||||000 ||eng|
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-2208582 URI
0247 a https://doi.org/10.1016/j.heliyon.2023.e220552 DOI
040 a (SwePub)umu
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Hussain, Nadiau Department of Pharmaceutical Sciences, College of Pharmacy, Al Ain University, Al Ain, United Arab Emirates4 aut
2451 0a Cichorium intybus L. significantly alleviates cigarette smoke-induced acute lung injury by lowering NF-κB pathway activation and inflammatory mediators
264 1b Elsevier,c 2023
338 a electronic2 rdacarrier
520 a Background: Cigarette smoke (CS) is one of the primary causes of acute lung injury (ALI) via provoking pulmonary inflammation and oxidative stress. Despite substantial studies, no effective treatment for ALI is presently available.Purpose: New prospective treatment options for ALI are required. Thus, this project was designed to investigate the in vivo and in vitro protective effects of 70 % methanolic-aqueous crude extract of whole plant of Cichorium intybus (Ci.Mce) against CS-induced ALI.Study design: /methods: Initially, male Swiss albino mice were subjected to whole-body CS exposure for 10 continuous days to prepare CS-induced ALI models. Normal saline (10 mL/kg), Ci.Mce (100, 200, 300 mg/kg), and Dexamethasone (1 mg/kg) were orally administered to respective animal groups 1 h prior to CS-exposure. 24 hrs after the last CS-exposure, BALF and lungs were harvested to study the key characteristics of ALI. Next, HPLC analysis was done to explore the phytoconstituents.Results: Ci.Mce exhibited significant reductions in lung macrophage and neutrophil infiltration, lung weight coefficient, and albumin exudation. Additionally, it effectively ameliorated lung histopathological alterations and hypoxemia. Notably, Ci.Mce exerted inhibitory effects on the excessive generation of IL-6, IL-1β, and KC in both CS-induced ALI murine models and CSE-stimulated RAW 264.7 macrophages. Noteworthy benefits included the attenuation of oxidative stress induced by CS, evidenced by decreased levels of MDA, TOS, and MPO, alongside enhanced TAC production. Furthermore, Ci.Mce demonstrated a marked reduction in CS-induced NF-κB expression, both in vivo and in vitro.Conclusion: Consequently, Cichorium intybus could be a therapeutic option for CS-induced ALI due to its ability to suppress inflammatory reactions, mitigate oxidative stress, and quell NF-κB p65 activation.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Farmakologi och toxikologi0 (SwePub)301022 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Pharmacology and Toxicology0 (SwePub)301022 hsv//eng
653 a ALI
653 a IL-1β
653 a IL-6
653 a MPO
653 a NF-κB p65
653 a TOS
7001 a Ikram, Nadiau Faculty of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, Pakistan4 aut
7001 a Khan, Kashif ur Rehmanu Faculty of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, Pakistan4 aut
7001 a Hussain, Liaqatu Department of Pharmacology, Government College University, Faisalabad, Pakistan4 aut
7001 a Alqahtani, Ali M.u Department of Pharmacology, College of Pharmacy, King Khalid University, Abha, Saudi Arabia4 aut
7001 a Alqahtani, Tahau Department of Pharmacology, College of Pharmacy, King Khalid University, Abha, Saudi Arabia4 aut
7001 a Hussain, Musaddiqueu Faculty of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, Pakistan4 aut
7001 a Suliman, Muathu Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, P.O. Box 61413, Abha, Saudi Arabia4 aut
7001 a Alshahrani, Mohammad Y.u Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, P.O. Box 61413, Abha, Saudi Arabia4 aut
7001 a Sitohy, Baselu Umeå universitet,Onkologi,Klinisk immunologi4 aut0 (Swepub:umu)balsiy01
7102 a Department of Pharmaceutical Sciences, College of Pharmacy, Al Ain University, Al Ain, United Arab Emiratesb Faculty of Pharmacy, The Islamia University of Bahawalpur, Bahawalpur, Pakistan4 org
7730 t Heliyond : Elsevierg 9:11q 9:11x 2405-8440
8564 u https://doi.org/10.1016/j.heliyon.2023.e22055y Fulltext
8564 u https://umu.diva-portal.org/smash/get/diva2:1838843/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-220858
8564 8u https://doi.org/10.1016/j.heliyon.2023.e22055

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