Sökning: (WFRF:(Tayo Bamidele O)) pers:(Tayo Bamidele O.) > New genetic loci li...
Fältnamn | Indikatorer | Metadata |
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000 | 22972naa a2205641 4500 | |
001 | oai:lup.lub.lu.se:3e5c03cd-7b22-4d63-b18b-b30b066e7fe9 | |
003 | SwePub | |
008 | 160401s2015 | |||||||||||000 ||eng| | |
009 | oai:DiVA.org:umu-100950 | |
009 | oai:DiVA.org:uu-244267 | |
009 | oai:DiVA.org:du-21323 | |
009 | oai:prod.swepub.kib.ki.se:130690385 | |
009 | oai:gup.ub.gu.se/213559 | |
024 | 7 | a https://lup.lub.lu.se/record/51444082 URI |
024 | 7 | a https://doi.org/10.1038/nature141322 DOI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1009502 URI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2442672 URI |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:du-213232 URI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:1306903852 URI |
024 | 7 | a https://gup.ub.gu.se/publication/2135592 URI |
040 | a (SwePub)lud (SwePub)umud (SwePub)uud (SwePub)dud (SwePub)kid (SwePub)gu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a art2 swepub-publicationtype |
072 | 7 | a ref2 swepub-contenttype |
100 | 1 | a Shungin, Dmitryu Umeå universitet,Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genetisk och molekylär epidemiologi,Genomics, Diabetes and Endocrinology,Lund University Research Groups,Genetic and Molecular Epidemiology,Medicin,Institutionen för odontologi4 aut0 (Swepub:umu)dmsh0003 |
245 | 1 0 | a New genetic loci link adipose and insulin biology to body fat distribution. |
264 | c 2015-02-11 | |
264 | 1 | b Springer Science and Business Media LLC,c 2015 |
520 | a Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Endokrinologi och diabetes0 (SwePub)302052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Endocrinology and Diabetes0 (SwePub)302052 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi0 (SwePub)303022 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Public Health, Global Health, Social Medicine and Epidemiology0 (SwePub)303022 hsv//eng |
653 | a Obesity: genetics | |
653 | a Physiologic: genetics | |
653 | a Neovascularization | |
653 | a Insulin Resistance: genetics | |
653 | a Insulin: metabolism | |
653 | a Human: genetics | |
653 | a Genome | |
653 | a Europe: ethnology | |
653 | a Continental Population Groups: genetics | |
653 | a Adipose Tissue: metabolism | |
653 | a Adipocytes: metabolism | |
653 | a Adipogenesis: genetics | |
653 | a Polymorphism | |
653 | a Single Nucleotide: genetics | |
653 | a Quantitative Trait Loci: genetics | |
653 | a Transcription | |
653 | a Genetic: genetics | |
653 | a Hälsa och välfärd | |
700 | 1 | a Winkler, Thomas W4 aut |
700 | 1 | a Croteau-Chonka, Damien C4 aut |
700 | 1 | a Ferreira, Teresa4 aut |
700 | 1 | a Locke, Adam E4 aut |
700 | 1 | a Mägi, Reedik4 aut |
700 | 1 | a Strawbridge, Rona Ju Karolinska Institutet4 aut |
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700 | 1 | a Drong, Alexander W4 aut |
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700 | 1 | a Erdos, Michael R4 aut |
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700 | 1 | a Friedrich, Nele4 aut |
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700 | 1 | a Giedraitis, Vilmantasu Uppsala universitet,Geriatrik4 aut0 (Swepub:uu)vigie517 |
700 | 1 | a Gigante, Brunau Karolinska Institutet4 aut |
700 | 1 | a Go, Alan S4 aut |
700 | 1 | a Golay, Alain4 aut |
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700 | 1 | a Grammer, Tanja B4 aut |
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700 | 1 | a Haller, Toomas4 aut |
700 | 1 | a Hallmans, Göranu Umeå universitet,Näringsforskning,Enheten för biobanksforskning4 aut0 (Swepub:umu)goha0001 |
700 | 1 | a Hartman, Catharina A4 aut |
700 | 1 | a Hassinen, Maija4 aut |
700 | 1 | a Hayward, Caroline4 aut |
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700 | 1 | a Helmer, Quinta4 aut |
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700 | 1 | a Hunt, Steven C4 aut |
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700 | 1 | a Juliusdottir, Thorhildur4 aut |
700 | 1 | a Kalafati, Ioanna-Panagiota4 aut |
700 | 1 | a Kinnunen, Leena4 aut |
700 | 1 | a Koenig, Wolfgang4 aut |
700 | 1 | a Kooner, Ishminder K4 aut |
700 | 1 | a Kratzer, Wolfgang4 aut |
700 | 1 | a Lamina, Claudia4 aut |
700 | 1 | a Leander, Karinu Karolinska Institutet4 aut |
700 | 1 | a Lee, Nanette R4 aut |
700 | 1 | a Lichtner, Peter4 aut |
700 | 1 | a Lind, Lars4 aut |
700 | 1 | a Lindström, Jaana4 aut |
700 | 1 | a Lobbens, Stéphane4 aut |
700 | 1 | a Lorentzon, Mattias,d 1970u Gothenburg University,Göteborgs universitet,Institutionen för medicin, avdelningen för invärtesmedicin och klinisk nutrition,Centre for Bone and Arthritis Research,Institute of Medicine, Department of Internal Medicine and Clinical Nutrition4 aut0 (Swepub:gu)xlomat |
700 | 1 | a Mach, François4 aut |
700 | 1 | a Magnusson, Patrik K Eu Karolinska Institutet4 aut |
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700 | 1 | a McArdle, Wendy L4 aut |
700 | 1 | a Menni, Cristina4 aut |
700 | 1 | a Merger, Sigrun4 aut |
700 | 1 | a Mihailov, Evelin4 aut |
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700 | 1 | a Mills, Rebecca4 aut |
700 | 1 | a Moayyeri, Alireza4 aut |
700 | 1 | a Monda, Keri L4 aut |
700 | 1 | a Mooijaart, Simon P4 aut |
700 | 1 | a Mühleisen, Thomas W4 aut |
700 | 1 | a Mulas, Antonella4 aut |
700 | 1 | a Müller, Gabriele4 aut |
700 | 1 | a Müller-Nurasyid, Martina4 aut |
700 | 1 | a Nagaraja, Ramaiah4 aut |
700 | 1 | a Nalls, Michael A4 aut |
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700 | 1 | a Rayner, Nigel W4 aut |
700 | 1 | a Renström, Fridau Lund University,Lunds universitet,Genetisk och molekylär epidemiologi,Forskargrupper vid Lunds universitet,Genetic and Molecular Epidemiology,Lund University Research Groups4 aut0 (Swepub:lu)med-frm |
700 | 1 | a Ried, Janina S4 aut |
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700 | 1 | a Sennblad, Bengtu Karolinska Institutet4 aut |
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700 | 1 | a Thorand, Barbara4 aut |
700 | 1 | a Thorleifsson, Gudmar4 aut |
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700 | 1 | a Eriksson, Per4 aut |
700 | 1 | a Folkersen, Lasse4 aut |
700 | 1 | a Franco-Cereceda, Andersu Karolinska Institutet4 aut |
700 | 1 | a Gharavi, Ali G4 aut |
700 | 1 | a Hedman, Åsa K4 aut |
700 | 1 | a Hivert, Marie-France4 aut |
700 | 1 | a Huang, Jinyan4 aut |
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700 | 1 | a Nyholt, Dale R4 aut |
700 | 1 | a Olsson, Christianu Karolinska Institutet4 aut |
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700 | 1 | a Sandholm, Niina4 aut |
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700 | 1 | a de Faire, Ulfu Karolinska Institutet4 aut |
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700 | 1 | a Lyssenko, Valeriyau Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-vly |
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700 | 1 | a Power, Chris4 aut |
700 | 1 | a Quertermous, Thomas4 aut |
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700 | 1 | a Saaristo, Timo E4 aut |
700 | 1 | a Saleheen, Danish4 aut |
700 | 1 | a Sinisalo, Juha4 aut |
700 | 1 | a Slagboom, P Eline4 aut |
700 | 1 | a Snieder, Harold4 aut |
700 | 1 | a Spector, Tim D4 aut |
700 | 1 | a Thorsteinsdottir, Unnur4 aut |
700 | 1 | a Stumvoll, Michael4 aut |
700 | 1 | a Tuomilehto, Jaakko4 aut |
700 | 1 | a Uitterlinden, André G4 aut |
700 | 1 | a Uusitupa, Matti4 aut |
700 | 1 | a van der Harst, Pim4 aut |
700 | 1 | a Veronesi, Giovanni4 aut |
700 | 1 | a Walker, Mark4 aut |
700 | 1 | a Wareham, Nicholas J4 aut |
700 | 1 | a Watkins, Hugh4 aut |
700 | 1 | a Wichmann, H-Erich4 aut |
700 | 1 | a Abecasis, Goncalo R4 aut |
700 | 1 | a Assimes, Themistocles L4 aut |
700 | 1 | a Berndt, Sonja I4 aut |
700 | 1 | a Boehnke, Michael4 aut |
700 | 1 | a Borecki, Ingrid B4 aut |
700 | 1 | a Deloukas, Panos4 aut |
700 | 1 | a Franke, Lude4 aut |
700 | 1 | a Frayling, Timothy M4 aut |
700 | 1 | a Groop, Leifu Lund University,Lunds universitet,Genomik, diabetes och endokrinologi,Forskargrupper vid Lunds universitet,Genomics, Diabetes and Endocrinology,Lund University Research Groups4 aut0 (Swepub:lu)endo-lgr |
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