Omega-3 and omega-6 polyunsaturated fatty acid biomarkers and sleep: a pooled analysis of cohort studies On behalf of the Fatty Acids and Outcomes Research Consortium (FORCE).

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Fältnamn	Indikatorer	Metadata
000		05431naa a2200757 4500
001		oai:DiVA.org:uu-462880
003		SwePub
008		220103s2022 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
024	7	a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4628802 URI
024	7	a https://doi.org/10.1093/ajcn/nqab4082 DOI
040		a (SwePub)uu
041		a engb eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Murphy, Rachel A4 aut
245	1 0	a Omega-3 and omega-6 polyunsaturated fatty acid biomarkers and sleep :b a pooled analysis of cohort studies On behalf of the Fatty Acids and Outcomes Research Consortium (FORCE).
264	1	b Oxford University Press (OUP),c 2022
338		a electronic2 rdacarrier
520		a BACKGROUND: n-3 and n-6 polyunsaturated fatty acids (PUFAs) have physiologic roles in sleep processes, but little is known regarding circulating n-3 and n-6 PUFA and sleep parameters.OBJECTIVES: To assess associations between biomarkers of n-3 and n-6 PUFA intake with self-reported sleep duration and difficulty falling sleeping in the Fatty Acids and Outcome Research Consortium.METHODS: Harmonized, de novo, individual-level analyses were performed and pooled across 12 cohorts. Participants were between 35 to 96 years old and from 5 nations. Circulating measures included alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA), docosahexaenoic acid (DHA), EPA + DPA + DHA, linoleic acid and arachidonic acid. Sleep duration (10 cohorts, N = 18,791) was categorized as short (≤6 hours), 7-8 hours (reference) or long (9 + hours). Difficulty falling sleeping (8 cohorts, N = 12,500) was categorized as yes or no. Associations between PUFAs, sleep duration, and difficulty falling sleeping were assessed by cross-sectional multinomial logistic regression using standardized protocols and covariates. Cohort-specific multivariable-adjusted odds ratios (ORs) per quintile of PUFAs were pooled with inverse-variance weighted meta-analysis.RESULTS: In pooled analysis adjusted for sociodemographics and health status, participants with higher very long-chain n-3 PUFAs were less likely to have long sleep duration. Comparing top vs. bottom quintiles, the multivariable-adjusted OR (95% confidence interval, CI) for long-sleep was 0.78 (0.65, 0.95) for DHA and for EPA + DPA + DHA, 0.76 (0.63, 0.93). Significant associations were not identified for ALA and n-6 PUFA with short sleep duration, or difficulty falling sleeping.CONCLUSIONS: Participants with higher levels of very long-chain n-3 PUFAs were less likely to have long sleep duration. While objective biomarkers reduce recall bias and misclassification, the cross-sectional design limits assessment of the temporal nature of this relationship. These novel findings across 12 cohorts highlight the need for experimental and biological assessments of very long-chain n-3 PUFAs and sleep duration.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Hälsovetenskapx Näringslära0 (SwePub)303042 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Health Sciencesx Nutrition and Dietetics0 (SwePub)303042 hsv//eng
653		a biomarkers
653		a diet
653		a fatty acids
653		a omega-3
653		a public health
653		a sleep quality
700	1	a Tintle, Nathan4 aut
700	1	a Harris, William S4 aut
700	1	a Darvishian, Maryam4 aut
700	1	a Marklund, Mattiu Uppsala universitet,Klinisk nutrition och metabolism4 aut0 (Swepub:uu)matma701
700	1	a Virtanen, Jyrki K4 aut
700	1	a Hantunen, Sari4 aut
700	1	a de Mello, Vanessa D4 aut
700	1	a Tuomilehto, Jaakko4 aut
700	1	a Lindström, Jaana4 aut
700	1	a Bolt, Matthew A4 aut
700	1	a Brouwer, Ingeborg A4 aut
700	1	a Wood, Alexis C4 aut
700	1	a Senn, Mackenzie4 aut
700	1	a Redline, Susan4 aut
700	1	a Tsai, Michael Y4 aut
700	1	a Gudnason, Vilmundur4 aut
700	1	a Eiriksdottir, Gudny4 aut
700	1	a Lindberg, Evau Uppsala universitet,Lungmedicin och allergologi,Lungmedicin och allergologi, Respiratory Medicine and Allergology4 aut0 (Swepub:uu)evalb
700	1	a Shadyab, Aladdin H4 aut
700	1	a Liu, Buyun4 aut
700	1	a Carnethon, Mercedes4 aut
700	1	a Uusitupa, Matti4 aut
700	1	a Djousse, Luc4 aut
700	1	a Risérus, Ulf,d 1967-u Uppsala universitet,Klinisk nutrition och metabolism4 aut0 (Swepub:uu)ulfriser
700	1	a Lind, Lars4 aut
700	1	a van Dam, Rob M4 aut
700	1	a Koh, Woon-Puay4 aut
700	1	a Shi, Peilin4 aut
700	1	a Siscovick, David4 aut
700	1	a Lemaitre, Rozenn N4 aut
700	1	a Mozaffarian, Dariush4 aut
710	2	a Uppsala universitetb Klinisk nutrition och metabolism4 org
773	0	t American Journal of Clinical Nutritiond : Oxford University Press (OUP)g 115:3, s. 864-876q 115:3<864-876x 0002-9165x 1938-3207
856	4	u https://doi.org/10.1093/ajcn/nqab408y Fulltext
856	4	u https://uu.diva-portal.org/smash/get/diva2:1624327/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856	4	u https://academic.oup.com/ajcn/advance-article-pdf/doi/10.1093/ajcn/nqab408/42371451/nqab408.pdf
856	4 8	u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-462880
856	4 8	u https://doi.org/10.1093/ajcn/nqab408

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