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13-cis-retinoic aci...
13-cis-retinoic acid competitively inhibits 3 alpha-hydroxysteroid oxidation by retinol dehydrogenase RoDH-4 : a mechanism for its anti-androgenic effects in sebaceous glands?
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- Karlsson, Teresa (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Dermatology and Venereology
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- Vahlquist, Anders (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Dermatology and Venereology
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Kedishvili, Natalia (författare)
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- Törmä, Hans (författare)
- Uppsala universitet,Institutionen för medicinska vetenskaper,Dermatology and Venereology
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(creator_code:org_t)
- 2003
- 2003
- Engelska.
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Ingår i: Biochemical and Biophysical Research Communications - BBRC. - 0006-291X .- 1090-2104. ; 303:1, s. 273-278
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Retinol dehydrogenase-4 (RoDH-4) converts retinol and 13-cis-retinol to corresponding aldehydes in human liver and skin in the presence of NAD(+). RoDH-4 also converts 3 alpha-androstanediol and androsterone into dihydrotestosterone and androstanedione, which may stimulate sebum secretion. This oxidative 3 alpha-hydroxysteroid dehydrogenase (3 alpha-HSD) activity of RoDH-4 is competitively inhibited by retinol and 13-cis-retinol. Here, we further examine the substrate specificity of RoDH-4 and the inhibition of its 3 alpha-HSD activity by retinoids. Recombinant RoDH-4 oxidized 3,4-didehydroretinol-a major form of vitamin A in the skin-to its corresponding aldehyde. 13-cis-retinoic acid (isotretinoin), 3,4-didehydroretinoic acid, and 3,4-didehydroretinol, but not all-trans-retinoic acid or the synthetic retinoids acitretin and adapalene, were potent competitive inhibitors of the oxidative 3 alpha-HSD activity of RoDH-4, i.e., reduced the formation of dihydrotestosterone and androstandione in vitro. Extrapolated to the in vivo situation, this effect might explain the unique sebosuppressive effect of isotretinoin when treating acne.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Dermatologi och venereologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dermatology and Venereal Diseases (hsv//eng)
Nyckelord
- Acne
- Isotretinoin
- Retinol dehydrogenase
- Skin
- Epidermis
- Retinoid
- Enzyme kinetics
- Androgen
- Retinoic acid
- MEDICINE
- MEDICIN
- Dermatology and venerology
- Dermatologi och venerologi
- Dermatology and Venerology
- Dermatologi och venereologi
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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