Potential for clinical radionuclide-based imaging and therapy of common cancers expressing EGFR-family receptors

• High expression of epidermal growth factor receptor (EGFR)-family receptors, especially EGFR, HER2, and HER3, makes them interesting for targeted radionuclide-based imaging and therapy of disseminated cancer. The expression in some commonly occurring cancers such as breast, prostate, colorectal, and urinary bladder cancers is summarized. Possible strategies for radionuclide-based imaging and therapy are briefly discussed, especially in relation to the receptor expression in metastases.

Nyckelord

EGFR

HER2

HER3

HER4

Imaging

Metastasis

Radionuclide

Receptors

Therapy

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)