L773:1791 7530 OR L773:0250 7005
Search: L773:1791 7530 OR L773:0250 7005 > (2020-2024) > Post-resection Cavi...
- 10 of 53
- Previous record
- Next record
- To hitlist
Post-resection Cavity Lavage of High Grade Glioma With a Novel Drug Combination : A Case Report
-
- Ganapathy, Sibhi (author)
- St Johns Med Coll, Dept Neurosurg, Bangalore, India.
-
- Venkataramana, Neelam K. (author)
- BRAINS Super Special Hosp, Bangalore, India.
-
- Av Rao, Shailesh (author)
- St Johns Med Coll, Dept Neurosurg, Bangalore, India.
- show more...
- show less...
- St Johns Med Coll, Dept Neurosurg, Bangalore, India BRAINS Super Special Hosp, Bangalore, India. (creator_code:org_t)
- Anticancer Research USA Inc. 2023
- 2023
- English.
- In: Anticancer Research. - : Anticancer Research USA Inc.. - 0250-7005 .- 1791-7530. ; 43:8, s. 3583-3588
- Journal article (peer-reviewed)
Abstract
Subject headings
Close
- Background: High grade gliomas are the most common and most lethal primary cancers of the central nervous system.Case Report: We herein present a case report of a long-term surviving 36-year-old female diagnosed with high grade glioma, for which she underwent neurosurgery with a gross total removal of the tumor. Shortly thereafter (<3 months) she was readmitted in a desolate state due to a large recurrence. After Ethical Committee approval, proper explanation, and consent from spouse, she was subjected to a reoperation involving a post-operative infusion into the excised tumor cavity, containing a mixture of a non-physiological amino acid in millimolar concentration and a proapoptotic drug in micromolar concentration. The patient tolerated the treatment well and was discharged in a stable state thereafter. A series of follow ups revealed successive clinical improvements and after 4-6 months, she had recovered with mild left hemiparesis, meaning that she was able to carry out activities of daily living independently. Now, 5.5 years later, after the recurrence and the infusion therapy, she continues to have a mild left hemiparesis and her MRI with contrast shows no evidence of tumor. Conclusion: Continuous intratumoral infusion therapy with an artificial amino acid combined with a proapoptotic drug results in complete glioma cell lysis both in vitro and in vivo.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
Keyword
- Glioma
- diaminobutyric acid
- prazosin
- drug combination
- amino acids
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
- Anticancer Research (Search for host publication in LIBRIS)
To the university's database
- 10 of 53
- Previous record
- Next record
- To hitlist
Find more in SwePub
- By the author/editor
- Ganapathy, Sibhi
- Venkataramana, N ...
- Av Rao, Shailesh
- Nagaraj, Anmol
- Panayotou, Georg ...
- Panotopoulos, Ch ...
- show more...
- Rönquist, Gunnar
- show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Neurology
-
- MEDICAL AND HEALTH SCIENCES
- MEDICAL AND HEAL ...
- and Clinical Medicin ...
- and Cancer and Oncol ...
- Articles in the publication
- Anticancer Resea ...
- By the university
- Uppsala University
Search outside SwePub
- Extend your search to:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - National Library Systems
- LIBRIS.kb.se
