L773:2332 4252 OR L773:2332 4260
Sökning: L773:2332 4252 OR L773:2332 4260 > Optical Brain Biops...
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| Fältnamn | Indikatorer | Metadata |
|---|---|---|
| 000 | 04582naa a2200493 4500 | |
| 001 | oai:DiVA.org:liu-179467 | |
| 003 | SwePub | |
| 008 | 210921s2021 | |||||||||||000 ||eng| | |
| 024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1794672 URI |
| 024 | 7 | a https://doi.org/10.1093/ons/opab2162 DOI |
| 040 | a (SwePub)liu | |
| 041 | a engb eng | |
| 042 | 9 SwePub | |
| 072 | 7 | a ref2 swepub-contenttype |
| 072 | 7 | a art2 swepub-publicationtype |
| 100 | 1 | a Richter, Johanu Linköpings universitet,Tekniska fakulteten,Avdelningen för medicinsk teknik,Region Östergötland, Neurokirurgiska kliniken US4 aut0 (Swepub:liu)johri42 |
| 245 | 1 0 | a Optical Brain Biopsy with a Fluorescence and Vessel Tracing Probe |
| 264 | c 2021-10 | |
| 264 | 1 | b Oxford University Press,c 2021 |
| 338 | a electronic2 rdacarrier | |
| 500 | a Funding: LiU Cancer Strategic Research Grant; Swedish Childhood Cancer FoundationEuropean Commission [MT 20130043]; ALF Grants Region Ostergotland; Swedish Foundation for Strategic ResearchSwedish Foundation for Strategic Research [RMX18-0056] | |
| 520 | a BACKGROUND Accurate stereotactic biopsies of brain tumors are imperative for diagnosis and tailoring of the therapy. Repetitive needle insertions enhance risks of brain lesioning, hemorrhage, and complications due to prolonged procedure.OBJECTIVE To investigate clinical benefits of a combined 5-aminolaevulinic acid (5-ALA) fluorescence and laser Doppler flowmetry system for the detection of malignant brain tumor and blood vessels in stereotactic biopsies.METHODS Planning of targets and trajectories was followed by optical measurements in 20 patients, using the Leksell Stereotactic System and a manual insertion device. Fluorescence spectra, microvascular blood flow, and tissue grayness were recorded each millimeter along the paths. Biopsies were taken at preplanned positions. The diagnoses were compared with the fluorescence signals. The recordings were plotted against measurement positions and compared. Sites indicating a risk of hemorrhage were counted as well as the time for the procedures.RESULTS Signals were recorded along 28 trajectories, and 78 biopsies were collected. The final diagnosis showed 17 glioblastomas, 2 lymphomas, and 1 astrocytoma grade III. Fluorescence was seen along 23 of the paths with 4 having the peak of 5-ALA fluorescence 3 mm or more from the precalculated target. There was increased microcirculation in 40 of 905 measured positions. The measurement time for each trajectory was 5 to 10 min.CONCLUSION The probe provided direct feedback of increased blood flow along the trajectory and of malignant tissue in the vicinity of the target. The method can increase the precision and the safety of the biopsy procedure and reduce time. | |
| 650 | 7 | a TEKNIK OCH TEKNOLOGIERx Medicinteknikx Annan medicinteknik0 (SwePub)206992 hsv//swe |
| 650 | 7 | a ENGINEERING AND TECHNOLOGYx Medical Engineeringx Other Medical Engineering0 (SwePub)206992 hsv//eng |
| 650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Kirurgi0 (SwePub)302122 hsv//swe |
| 650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Surgery0 (SwePub)302122 hsv//eng |
| 653 | a Biopsy | |
| 653 | a Optical | |
| 653 | a Tumor | |
| 653 | a Fluorescence | |
| 653 | a Spectroscopy | |
| 653 | a Stereotactic navigation | |
| 653 | a 5-ALA | |
| 700 | 1 | a Haj-Hosseini, Nedau Linköpings universitet,Avdelningen för medicinsk teknik,Tekniska fakulteten4 aut0 (Swepub:liu)nedha71 |
| 700 | 1 | a Milos, Peteru Linköpings universitet,Medicinska fakulteten,Avdelningen för neurobiologi,Region Östergötland, Neurokirurgiska kliniken US4 aut0 (Swepub:liu)petmi52 |
| 700 | 1 | a Hallbeck, Martinu Linköpings universitet,Avdelningen för neurobiologi,Medicinska fakulteten,Region Östergötland, Klinisk patologi4 aut0 (Swepub:liu)marha90 |
| 700 | 1 | a Wårdell, Karinu Linköpings universitet,Avdelningen för medicinsk teknik,Tekniska fakulteten,MINT4 aut0 (Swepub:liu)karwa46 |
| 710 | 2 | a Linköpings universitetb Tekniska fakulteten4 org |
| 773 | 0 | t Operative Neurosurgeryd : Oxford University Pressg 21:4, s. 217-224q 21:4<217-224x 2332-4252x 2332-4260 |
| 856 | 4 | u https://doi.org/10.1093/ons/opab216y Fulltext |
| 856 | 4 | u https://liu.diva-portal.org/smash/get/diva2:1595973/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
| 856 | 4 | u https://academic.oup.com/ons/article-pdf/21/4/217/40331555/opab216.pdf |
| 856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-179467 |
| 856 | 4 8 | u https://doi.org/10.1093/ons/opab216 |
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