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Pandemrix® vaccinat...
Pandemrix® vaccination is not associated with increased risk of islet autoimmunity or type 1 diabetes in the TEDDY study children
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- Elding Larsson, Helena (författare)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine
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- Lynch, Kristian F. (författare)
- University of South Florida
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- Lönnrot, Maria (författare)
- Tampere University Hospital,University of Tampere
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- Haller, Michael J (författare)
- University of Florida
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- Lernmark, Åke (författare)
- Lund University,Lunds universitet,Institutionen för kliniska vetenskaper, Malmö,Medicinska fakulteten,Department of Clinical Sciences, Malmö,Faculty of Medicine
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- Hagopian, William A. (författare)
- Pacific Northwest Research Institute
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- She, Jin-Xiong (författare)
- Medical College of Georgia
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- Simell, Olli (författare)
- Turku University Hospital
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- Toppari, Jorma (författare)
- University of Turku,Turku University Hospital
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- Ziegler, Anette-G. (författare)
- Klinikum rechts der Isar
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- Akolkar, Beena (författare)
- National Institute of Diabetes and Digestive and Kidney Diseases
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- Krischer, Jeffrey P. (författare)
- University of South Florida
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- Rewers, Marian J. (författare)
- University of Colorado
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- Hyöty, Heikki (författare)
- University of Tampere
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(creator_code:org_t)
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- 2017-10-09
- 2018
- Engelska.
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Ingår i: Diabetologia. - : Springer Science and Business Media LLC. - 0012-186X .- 1432-0428. ; 61:1, s. 193-202
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http://dx.doi.org/10... (free)
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https://link.springe...
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Aims/hypothesis: During the A/H1N1 2009 (A/California/04/2009) pandemic, mass vaccination with a squalene-containing vaccine, Pandemrix®, was performed in Sweden and Finland. The vaccination was found to cause narcolepsy in children and young adults with the HLA-DQ 6.2 haplotype. The aim of this study was to investigate if exposure to Pandemrix® similarly increased the risk of islet autoimmunity or type 1 diabetes. Methods: In The Environmental Determinants of Diabetes in the Young (TEDDY) study, children are followed prospectively for the development of islet autoimmunity and type 1 diabetes. In October 2009, when the mass vaccination began, 3401 children at risk for islet autoimmunity and type 1 diabetes were followed in Sweden and Finland. Vaccinations were recorded and autoantibodies against insulin, GAD65 and insulinoma-associated protein 2 were ascertained quarterly before the age of 4 years and semi-annually thereafter. Results: By 5 August 2010, 2413 of the 3401 (71%) children observed as at risk for an islet autoantibody or type 1 diabetes on 1 October 2009 had been vaccinated with Pandemrix®. By 31 July 2016, 232 children had at least one islet autoantibody before 10 years of age, 148 had multiple islet autoantibodies and 96 had developed type 1 diabetes. The risk of islet autoimmunity was not increased among vaccinated children. The HR (95% CI) for the appearance of at least one islet autoantibody was 0.75 (0.55, 1.03), at least two autoantibodies was 0.85 (0.57, 1.26) and type 1 diabetes was 0.67 (0.42, 1.07). In Finland, but not in Sweden, vaccinated children had a lower risk of islet autoimmunity (0.47 [0.29, 0.75]), multiple autoantibodies (0.50 [0.28, 0.90]) and type 1 diabetes (0.38 [0.20, 0.72]) compared with those who did not receive Pandemrix®. The analyses were adjusted for confounding factors. Conclusions/interpretation: Children with an increased genetic risk for type 1 diabetes who received the Pandemrix® vaccine during the A/H1N1 2009 pandemic had no increased risk of islet autoimmunity, multiple islet autoantibodies or type 1 diabetes. In Finland, the vaccine was associated with a reduced risk of islet autoimmunity and type 1 diabetes.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Nyckelord
- Influenza vaccine
- Islet autoimmunity
- Pandemrix
- Squalene
- Swine flu
- Type 1 diabetes
- Vaccination
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- art (ämneskategori)
- ref (ämneskategori)
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Elding Larsson, ...
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Lynch, Kristian ...
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Lönnrot, Maria
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Haller, Michael ...
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Lernmark, Åke
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Hagopian, Willia ...
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She, Jin-Xiong
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Simell, Olli
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Toppari, Jorma
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Ziegler, Anette- ...
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Akolkar, Beena
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Krischer, Jeffre ...
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Rewers, Marian J ...
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Hyöty, Heikki
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