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Polysaccharide Caps...
Polysaccharide Capsules Equip the Human Symbiont Bacteroides thetaiotaomicron to Modulate Immune Responses to a Dominant Antigen in the Intestine
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- Hsieh, Samantha (författare)
- Washington University in St. Louis
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- Porter, Nathan, 1986 (författare)
- Chalmers tekniska högskola,Chalmers University of Technology
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- Donermeyer, David L. (författare)
- Washington University in St. Louis
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- Horvath, Stephen (författare)
- Washington University in St. Louis
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- Strout, Gregory (författare)
- Washington University in St. Louis
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- Saunders, Brian T. (författare)
- Washington University in St. Louis
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- Zhang, Nan (författare)
- Washington University in St. Louis
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- Zinselmeyer, Bernd (författare)
- Washington University in St. Louis
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- Martens, Eric C. (författare)
- University of Michigan
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- Stappenbeck, Thaddeus S. (författare)
- Washington University in St. Louis
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- Allen, Paul M. (författare)
- Washington University in St. Louis
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Washington University in St Louis Chalmers tekniska högskola (creator_code:org_t)
- 2020-02-15
- 2020
- Engelska.
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Ingår i: Journal of Immunology. - : The American Association of Immunologists. - 1550-6606 .- 0022-1767. ; 204:4, s. 1035-1046
- Relaterad länk:
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https://www.jimmunol...
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https://research.cha...
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https://doi.org/10.4...
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Abstract
Ämnesord
Stäng
- Bacteria express multiple diverse capsular polysaccharides (CPSs) for protection against environmental and host factors, including the host immune system. Using a mouse TCR transgenic CD4+ T cell, BθOM, that is specific for B. thetaiotaomicron and a complete set of single CPS-expressing B. thetaiotaomicron strains, we ask whether CPSs can modify the immune responses to specific bacterial Ags. Acapsular B. thetaiotaomicron, which lacks all B. thetaiotaomicron CPSs, stimulated BθOM T cells more strongly than wild-type B. thetaiotaomicron Despite similar levels of BθOM Ag expression, many single CPS-expressing B. thetaiotaomicron strains were antistimulatory and weakly activated BθOM T cells, but a few strains were prostimulatory and strongly activated BθOM T cells just as well or better than an acapsular strain. B. thetaiotaomicron strains that expressed an antistimulatory CPS blocked Ag delivery to the immune system, which could be rescued by Fc receptor-dependent Ab opsonization. All single CPS-expressing B. thetaiotaomicron strains stimulated the innate immune system to skew toward M1 macrophages and release inflammatory cytokines in an MyD88-dependent manner, with antistimulatory CPS activating the innate immune system in a weaker manner than prostimulatory CPS. The expression of antistimulatory versus prostimulatory CPSs on outer membrane vesicles also regulated immune responses. Moreover, antistimulatory and prostimulatory single CPS-expressing B. thetaiotaomicron strains regulated the activation of Ag-specific and polyclonal T cells as well as clearance of dominant Ag in vivo. These studies establish that the immune responses to specific bacterial Ags can be modulated by a diverse set of CPSs.
Ämnesord
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Cell- och molekylärbiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Cell and Molecular Biology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Immunologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Immunology in the medical area (hsv//eng)
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Hsieh, Samantha
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Porter, Nathan, ...
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Donermeyer, Davi ...
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Horvath, Stephen
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Strout, Gregory
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Saunders, Brian ...
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visa fler...
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Zhang, Nan
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Zinselmeyer, Ber ...
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Martens, Eric C.
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Stappenbeck, Tha ...
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Allen, Paul M.
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visa färre...
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Chalmers tekniska högskola