Sökning: WFRF:(Amos Christopher) > Identification of s...
Fältnamn | Indikatorer | Metadata |
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000 | 08400naa a2201885 4500 | |
001 | oai:DiVA.org:umu-151046 | |
003 | SwePub | |
008 | 180905s2018 | |||||||||||000 ||eng| | |
009 | oai:lup.lub.lu.se:1047e608-12e3-4f81-a538-f28059dbd862 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1510462 URI |
024 | 7 | a https://doi.org/10.1038/s41467-018-05074-y2 DOI |
024 | 7 | a https://lup.lub.lu.se/record/1047e608-12e3-4f81-a538-f28059dbd8622 URI |
040 | a (SwePub)umud (SwePub)lu | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Ji, Xuemeiu Dartmouth College4 aut |
245 | 1 0 | a Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk |
264 | c 2018-08-13 | |
264 | 1 | b NATURE PUBLISHING GROUP,c 2018 |
338 | a electronic2 rdacarrier | |
520 | a Genome-wide association studies (GWAS) identified the chromosome 15q25.1 locus as a leading susceptibility region for lung cancer. However, the pathogenic pathways, through which susceptibility SNPs within chromosome 15q25.1 affects lung cancer risk, have not been explored. We analyzed three cohorts with GWAS data consisting 42,901 individuals and lung expression quantitative trait loci (eQTL) data on 409 individuals to identify and validate the underlying pathways and to investigate the combined effect of genes from the identified susceptibility pathways. The KEGG neuroactive ligand receptor interaction pathway, two Reactome pathways, and 22 Gene Ontology terms were identified and replicated to be significantly associated with lung cancer risk, with P values less than 0.05 and FDR less than 0.1. Functional annotation of eQTL analysis results showed that the neuroactive ligand receptor interaction pathway and gated channel activity were involved in lung cancer risk. These pathways provide important insights for the etiology of lung cancer. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Medicinsk genetik0 (SwePub)301072 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Medical Genetics0 (SwePub)301072 hsv//eng |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Cancer och onkologi0 (SwePub)302032 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Cancer and Oncology0 (SwePub)302032 hsv//eng |
700 | 1 | a Bosse, Yohan4 aut |
700 | 1 | a Landi, Maria Teresa4 aut |
700 | 1 | a Gui, Jiang4 aut |
700 | 1 | a Xiao, Xiangjun4 aut |
700 | 1 | a Qian, David4 aut |
700 | 1 | a Joubert, Philippe4 aut |
700 | 1 | a Lamontagne, Maxime4 aut |
700 | 1 | a Li, Yafang4 aut |
700 | 1 | a Gorlov, Ivan4 aut |
700 | 1 | a de Biasi, Mariella4 aut |
700 | 1 | a Han, Younghun4 aut |
700 | 1 | a Gorlova, Olga4 aut |
700 | 1 | a Hung, Rayjean J.4 aut |
700 | 1 | a Wu, Xifeng4 aut |
700 | 1 | a Mckay, James4 aut |
700 | 1 | a Zong, Xuchen4 aut |
700 | 1 | a Carreras-Torres, Robert4 aut |
700 | 1 | a Christiani, David C.4 aut |
700 | 1 | a Caporaso, Neil4 aut |
700 | 1 | a Johansson, Mattias4 aut |
700 | 1 | a Liu, Geoffrey4 aut |
700 | 1 | a Bojesen, Stig E.4 aut |
700 | 1 | a Le Marchand, Loic4 aut |
700 | 1 | a Albanes, Demetrios4 aut |
700 | 1 | a Bickeboeller, Heike4 aut |
700 | 1 | a Aldrich, Melinda C.4 aut |
700 | 1 | a Bush, William S.4 aut |
700 | 1 | a Tardon, Adonina4 aut |
700 | 1 | a Rennert, Gad4 aut |
700 | 1 | a Chen, Chu4 aut |
700 | 1 | a Teare, M. Dawn4 aut |
700 | 1 | a Field, John K.4 aut |
700 | 1 | a Kiemeney, Lambertus A.4 aut |
700 | 1 | a Lazarus, Philip4 aut |
700 | 1 | a Haugen, Aage4 aut |
700 | 1 | a Lam, Stephen4 aut |
700 | 1 | a Schabath, Matthew B.4 aut |
700 | 1 | a Andrew, Angeline S.4 aut |
700 | 1 | a Shen, Hongbing4 aut |
700 | 1 | a Hong, Yun-Chul4 aut |
700 | 1 | a Yuan, Jian-Min4 aut |
700 | 1 | a Bertazzi, Pier A.4 aut |
700 | 1 | a Pesatori, Angela C.4 aut |
700 | 1 | a Ye, Yuanqing4 aut |
700 | 1 | a Diao, Nancy4 aut |
700 | 1 | a Su, Li4 aut |
700 | 1 | a Zhang, Ruyang4 aut |
700 | 1 | a Brhane, Yonathan4 aut |
700 | 1 | a Leighl, Natasha4 aut |
700 | 1 | a Johansen, Jakob S.4 aut |
700 | 1 | a Mellemgaard, Anders4 aut |
700 | 1 | a Saliba, Walid4 aut |
700 | 1 | a Haiman, Christopher4 aut |
700 | 1 | a Wilkens, Lynne4 aut |
700 | 1 | a Fernandez-Somoano, Ana4 aut |
700 | 1 | a Fernandez-Tardon, Guillermo4 aut |
700 | 1 | a van der Heijden, Erik H. F. M.4 aut |
700 | 1 | a Kim, Jin Hee4 aut |
700 | 1 | a Dai, Juncheng4 aut |
700 | 1 | a Hu, Zhibin4 aut |
700 | 1 | a Davies, Michael P. A.4 aut |
700 | 1 | a Marcus, Michael W.4 aut |
700 | 1 | a Brunnström, Hansu Lund University,Lunds universitet,Förbättrad diagnostik och prognostik vid lungcancer och metastaser till lunga,Forskargrupper vid Lunds universitet,Improved diagnostics and prognostics of lung cancer and metastases to the lungs,Lund University Research Groups4 aut0 (Swepub:lu)med-hsb |
700 | 1 | a Manjer, Jonasu Lund University,Lunds universitet,Kirurgi,Forskargrupper vid Lunds universitet,Surgery,Lund University Research Groups4 aut0 (Swepub:lu)smi-jma |
700 | 1 | a Melander, Olleu Lund University,Lunds universitet4 aut0 (Swepub:lu)endo-ome |
700 | 1 | a Muller, David C.4 aut |
700 | 1 | a Overvad, Kimu Lund University4 aut |
700 | 1 | a Trichopoulou, Antonia4 aut |
700 | 1 | a Tumino, Rosario4 aut |
700 | 1 | a Doherty, Jennifer4 aut |
700 | 1 | a Goodman, Gary E.4 aut |
700 | 1 | a Cox, Angela4 aut |
700 | 1 | a Taylor, Fiona4 aut |
700 | 1 | a Woll, Penella4 aut |
700 | 1 | a Brueske, Irene4 aut |
700 | 1 | a Manz, Judith4 aut |
700 | 1 | a Muley, Thomas4 aut |
700 | 1 | a Risch, Angela4 aut |
700 | 1 | a Rosenberger, Albert4 aut |
700 | 1 | a Grankvist, Kjellu Umeå universitet,Klinisk kemi4 aut0 (Swepub:umu)kjgr0002 |
700 | 1 | a Johansson, Mikaelu Umeå universitet,Onkologi4 aut0 (Swepub:umu)mijo0025 |
700 | 1 | a Shepherd, Frances4 aut |
700 | 1 | a Tsao, Ming-Sound4 aut |
700 | 1 | a Arnold, Susanne M.4 aut |
700 | 1 | a Haura, Eric B.4 aut |
700 | 1 | a Bolca, Ciprian4 aut |
700 | 1 | a Holcatova, Ivana4 aut |
700 | 1 | a Janout, Vladimir4 aut |
700 | 1 | a Kontic, Milica4 aut |
700 | 1 | a Lissowska, Jolanta4 aut |
700 | 1 | a Mukeria, Anush4 aut |
700 | 1 | a Ognjanovic, Simona4 aut |
700 | 1 | a Orlowski, Tadeusz M.4 aut |
700 | 1 | a Scelo, Ghislaine4 aut |
700 | 1 | a Swiatkowska, Beata4 aut |
700 | 1 | a Zaridze, David4 aut |
700 | 1 | a Bakke, Per4 aut |
700 | 1 | a Skaug, Vidar4 aut |
700 | 1 | a Zienolddiny, Shanbeh4 aut |
700 | 1 | a Duell, Eric J.4 aut |
700 | 1 | a Butler, Lesley M.4 aut |
700 | 1 | a Koh, Woon-Puay4 aut |
700 | 1 | a Gao, Yu-Tang4 aut |
700 | 1 | a Houlston, Richard4 aut |
700 | 1 | a McLaughlin, John4 aut |
700 | 1 | a Stevens, Victoria4 aut |
700 | 1 | a Nickle, David C.4 aut |
700 | 1 | a Obeidat, Ma'en4 aut |
700 | 1 | a Timens, Wim4 aut |
700 | 1 | a Zhu, Bin4 aut |
700 | 1 | a Song, Lei4 aut |
700 | 1 | a Artigas, Maria Soler4 aut |
700 | 1 | a Tobin, Martin D.4 aut |
700 | 1 | a Wain, Louise V.4 aut |
700 | 1 | a Gu, Fangyi4 aut |
700 | 1 | a Byun, Jinyoung4 aut |
700 | 1 | a Kamal, Ahsan4 aut |
700 | 1 | a Zhu, Dakai4 aut |
700 | 1 | a Tyndale, Rachel F.4 aut |
700 | 1 | a Wei, Wei-Qi4 aut |
700 | 1 | a Chanock, Stephen4 aut |
700 | 1 | a Brennan, Paul4 aut |
700 | 1 | a Amos, Christopher I.u Dartmouth College4 aut |
710 | 2 | a Dartmouth Collegeb Förbättrad diagnostik och prognostik vid lungcancer och metastaser till lunga4 org |
710 | 2 | a et al. |
773 | 0 | t Nature Communicationsd : NATURE PUBLISHING GROUPg 9, s. 1-15q 9<1-15x 2041-1723 |
856 | 4 | u https://doi.org/10.1038/s41467-018-05074-yy Fulltext |
856 | 4 | u https://umu.diva-portal.org/smash/get/diva2:1245321/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u https://www.nature.com/articles/s41467-018-05074-y.pdf |
856 | 4 | u http://dx.doi.org/10.1038/s41467-018-05074-yx freey FULLTEXT |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-151046 |
856 | 4 8 | u https://doi.org/10.1038/s41467-018-05074-y |
856 | 4 8 | u https://lup.lub.lu.se/record/1047e608-12e3-4f81-a538-f28059dbd862 |
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