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Effectiveness of Ha...
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Baqui, Abdullah H.
(författare)
Effectiveness of Haemophilus influenzae type B conjugate vaccine on prevention of pneumonia and meningitis in Bangladeshi children : A case-control study
- Artikel/kapitelEngelska2007
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LIBRIS-ID:oai:DiVA.org:uu-144265
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https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-144265URI
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https://doi.org/10.1097/INF.0b013e31806166a0DOI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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Background: Few Asian countries have introduced Haemophilus influenzae type b (Hib) conjugate vaccine because of its cost and uncertainty regarding disease burden. Methods: To estimate the effectiveness of Hib conjugate vaccine in preventing pneumonia and meningitis in children age <2 years, an incident case-control study was conducted in a birth cohort of about 68,000 infants in Dhaka city, Bangladesh. DPT vaccine was systematically replaced, by a combined Hib-DPT vaccine in selected immunization centers of the study area. Four matched community- and 2 hospital-controls were randomly selected for each confirmed case of pneumonia and meningitis from the study area. Results: About 35% of the infants received each of the 3 doses of Hib-DPT vaccine. There were 2679 children who had a chest roentgenogram. For 475 children, a radiologist and a pediatrician independently identified substantial alveolar consolidation. Following at least 2 doses of Hib vaccine, the preventable fractions [95% confidence intervals (CI)] using community and hospital controls were 17% (- 10% to 38%) and 35% (13% to 52%) respectively. Of these 475 cases, 2 radiologists with the World Health Organization concurred with the findings for 343 patients, yielding preventable fractions of 34% (6% to 53%) and 44% (20% to 61%). Fifteen confirmed Hib meningitis cases were identified; the preventable fractions (95% CI) using community and hospital controls, respectively, were 89% (28% to 100%) and 93% (53% to 100%). Conclusions: The study documented that significant fractions of pneumonia and meningitis in Bangladeshi children age <2 years can be prevented by the Hib conjugate vaccine.
Ämnesord och genrebeteckningar
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hib vaccine
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effectiveness
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case-control study
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Bangladesh
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MEDICINE
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MEDICIN
Biuppslag (personer, institutioner, konferenser, titlar ...)
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El Arifeen, Shams
(författare)
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Saha, Samir K.
(författare)
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Persson, Lars-ÅkeUppsala universitet,Internationell mödra- och barnhälsovård (IMCH)(Swepub:uu)laper499
(författare)
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Zaman, K.
(författare)
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Gessner, Bradford D.
(författare)
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Moulton, Lawrence H.
(författare)
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Black, Robert E.
(författare)
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Santosham, Mathuram
(författare)
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Uppsala universitetInternationell mödra- och barnhälsovård (IMCH)
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:The Pediatric Infectious Disease Journal26:7, s. 565-5710891-36681532-0987
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