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Expression of cance...
Expression of cancer-testis antigens in the immune microenvironment of non-small cell lung cancer
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- Hikmet Noraddin, Feria (author)
- Uppsala universitet,Cancerprecisionsmedicin
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- Rassy, Marc (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi
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- Backman, Max, 1987- (author)
- Uppsala universitet,Cancerimmunterapi
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- Méar, Loren (author)
- Uppsala universitet,Cancerprecisionsmedicin
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- Mattsson, Johanna Sofia Margareta, 1985- (author)
- Uppsala universitet,Cancerimmunterapi
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- Djureinovic, Dijana (author)
- Uppsala universitet,Institutionen för immunologi, genetik och patologi,Yale Univ, Sch Med, Dept Med Med Oncol, New Haven, CT USA.
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- Botling, Johan (author)
- Uppsala universitet,Cancerprecisionsmedicin
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- Brunnström, Hans (author)
- Lund Univ, Dept Clin Sci Lund, Div Pathol, Lund, Sweden.
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- Micke, Patrick (author)
- Uppsala universitet,Cancerimmunterapi
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- Lindskog, Cecilia (author)
- Uppsala universitet,Cancerprecisionsmedicin
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(creator_code:org_t)
- John Wiley & Sons, 2023
- 2023
- English.
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In: Molecular Oncology. - : John Wiley & Sons. - 1574-7891 .- 1878-0261. ; 17:12, s. 2603-2617
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Abstract
Subject headings
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- The antigenic repertoire of tumors is critical for successful anti-cancer immune response and the efficacy of immunotherapy. Cancer-testis antigens (CTAs) are targets of humoral and cellular immune reactions. We aimed to characterize CTA expression in non-small cell lung cancer (NSCLC) in the context of the immune microenvironment. Of 90 CTAs validated by RNA sequencing, eight CTAs (DPEP3, EZHIP, MAGEA4, MAGEB2, MAGEC2, PAGE1, PRAME, and TKTL1) were selected for immunohistochemical profiling in cancer tissues from 328 NSCLC patients. CTA expression was compared with immune cell densities in the tumor environment and with genomic, transcriptomic, and clinical data. Most NSCLC cases (79%) expressed at least one of the analyzed CTAs, and CTA protein expression correlated generally with RNA expression. CTA profiles were associated with immune profiles: high MAGEA4 expression was related to M2 macrophages (CD163) and regulatory T cells (FOXP3), low MAGEA4 was associated with T cells (CD3), and high EZHIP was associated with plasma cell infiltration (adj. P-value < 0.05). None of the CTAs correlated with clinical outcomes. The current study provides a comprehensive evaluation of CTAs and suggests that their association with immune cells may indicate in situ immunogenic effects. The findings support the rationale to harness CTAs as targets for immunotherapy.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Klinisk laboratoriemedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Clinical Laboratory Medicine (hsv//eng)
Keyword
- cancer-testis antigens
- immune phenotype
- immune-oncology
- non-small cell lung cancer
Publication and Content Type
- ref (subject category)
- art (subject category)
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Hikmet Noraddin, ...
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Rassy, Marc
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Backman, Max, 19 ...
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Méar, Loren
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Mattsson, Johann ...
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Djureinovic, Dij ...
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Botling, Johan
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Brunnström, Hans
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Micke, Patrick
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Lindskog, Cecili ...
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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MEDICAL AND HEAL ...
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Molecular Oncolo ...
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Uppsala University