SwePub
Sök i LIBRIS databas

  Utökad sökning

WFRF:(Bahmanyar Shahram)
 

Sökning: WFRF:(Bahmanyar Shahram) > The association bet...

The association between exposure to interferon-beta during pregnancy and birth measurements in offspring of women with multiple sclerosis

Burkill, Sarah (författare)
Centre for Pharmacoepidemiology, Karolinska Institutet, Stockholm, Sweden; Division of Clinical Epidemiology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden
Vattulainen, Pia (författare)
EPID research, Helsinki, Finland
Geissbuehler, Yvonne (författare)
Novartis Pharma AG, Basel, Switzerland
visa fler...
Sabido Espin, Meritxell (författare)
Merck group, Darmstadt, Germany
Popescu, Catrinel (författare)
Biogen, Maidenhead, United Kingdom,Biogen, Maidenhead, UK
Suzart-Woischnik, Kiliana (författare)
Bayer AG, Berlin, Germany
Hillert, Jan (författare)
Karolinska Institutet,Karolinska Institute, Stockholm, Sweden
Artama, Miia (författare)
National Institute for Health and Welfare Finland, Helsinki, Finland
Verkkoniemi-Ahola, Auli (författare)
Department of Neurology, Helsinki University, Helsinki, Finland
Myhr, Kjell-Morten (författare)
Department of Clinical Medicine, University of Bergen, Bergen, Norway
Cnattingius, Sven (författare)
Karolinska Institutet,Karolinska Institute, Stockholm, Sweden
Korhonen, Pasi (författare)
EPID research, Helsinki, Finland
Montgomery, Scott, 1961- (författare)
Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Division of Clinical Epidemiology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; Department of Epidemiology and Public Health, University College London, London, United Kingdom,Clinical Epidemiology and Biostatistics
Bahmanyar, Shahram (författare)
Karolinska Institutet,Karolinska Institute, Stockholm, Sweden
visa färre...
 (creator_code:org_t)
2019-12-30
2019
Engelska.
Ingår i: PLOS ONE. - : PLOS. - 1932-6203. ; 28:Suppl. 2, s. 371-372
Relaterad länk:
https://doi.org/10.1...
visa fler...
https://journals.plo...
https://urn.kb.se/re...
https://doi.org/10.1...
http://kipublication...
https://urn.kb.se/re...
http://kipublication...
visa färre...
  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
Stäng  
  • BACKGROUND: Interferon-beta (IFN-beta) is a commonly used treatment for multiple sclerosis (MS). Current guidelines recommend cessation of treatment during pregnancy, however the results of past studies on the safety of prenatal exposure to IFN-beta have been conflicting. A large scale study of a population of MS women is therefore warranted.OBJECTIVES: To assess whether, among those born to women with MS, infants prenatally exposed to IFN-beta show evidence of smaller size at birth relative to infants which were not prenatally exposed to any MS disease modifying drugs.METHODS: Swedish and Finnish register data was used. Births to women with MS in Sweden and Finland between 2005-2014 for which a birth measurement for weight, height, and head circumference was available were included. The exposure window was from 6 months prior to LMP to the end of pregnancy.RESULTS: In Sweden, 411 pregnancies were identified as exposed to IFN-beta during the exposure window, and 835 pregnancies were counted as unexposed to any MS DMD. The corresponding numbers for Finland were 232 and 331 respectively. Infants prenatally exposed to interferon-beta were on average 28 grams heavier (p = 0.17), 0.01 cm longer (p = 0.95), and had head circumferences 0.14 cm larger (p = 0.13) in Sweden. In Finland, infants were 50 grams lighter (p = 0.27), 0.02 cm shorter (p = 0.92) and had head circumferences 0.22 cm smaller (p = 0.15) relative to those unexposed.CONCLUSIONS: This study provides evidence that exposure to IFN-beta during pregnancy does not influence birth weight, length, or head circumference.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)

Publikations- och innehållstyp

ref (ämneskategori)
art (ämneskategori)

Hitta via bibliotek

  • PLOS ONE (Sök värdpublikationen i LIBRIS)

Till lärosätets databas

Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.

 
pil uppåt Stäng

Kopiera och spara länken för att återkomma till aktuell vy