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Tumor-associated au...
Tumor-associated autoantibodies as early detection markers for ovarian cancer? : A prospective evaluation
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- Kaaks, Rudolf (författare)
- German Cancer Research Centre
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- Fortner, Renée Turzanski (författare)
- German Cancer Research Centre
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- Hüsing, Anika (författare)
- German Cancer Research Centre
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- Barrdahl, Myrto (författare)
- German Cancer Research Centre
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- Hopper, Marika (författare)
- Arizona State University
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- Johnson, Theron (författare)
- German Cancer Research Centre
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- Tjønneland, Anne (författare)
- Danish Cancer Society
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- Hansen, Louise (författare)
- Danish Cancer Society
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- Overvad, Kim (författare)
- Aarhus University
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- Fournier, Agnès (författare)
- University of Paris-Saclay
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- Boutron-Ruault, Marie-Christine (författare)
- University of Paris-Saclay
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- Kvaskoff, Marina (författare)
- University of Paris-Saclay
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- Dossus, Laure (författare)
- International Agency for Research on Cancer, World Health Organization
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- Johansson, Mattias (författare)
- International Agency for Research on Cancer, World Health Organization
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- Boeing, Heiner (författare)
- German Institute of Human Nutrition
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- Trichopoulou, Antonia (författare)
- National and Kapodistrian University of Athens
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- Benetou, Vassiliki (författare)
- National and Kapodistrian University of Athens
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- La Vecchia, Carlo (författare)
- University of Milan
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- Sieri, Sabina (författare)
- Istituto Nazionale dei Tumori,Arizona State University
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Mattiello, Amalia (författare)
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Palli, Domenico (författare)
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Tumino, Rosario (författare)
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- Matullo, Giuseppe (författare)
- Citta' della Salute e della Scienza Hospital-University of Turin
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- Onland-Moret, N. Charlotte (författare)
- University Medical Center Utrecht
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- Gram, Inger T. (författare)
- UiT The Arctic University of Norway, Tromsø
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- Weiderpass, Elisabete (författare)
- Karolinska Institutet,Folkhälsan Research Center
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Sánchez, Maria-Jose (författare)
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- Navarro Sanchez, Carmen (författare)
- Murcia Regional Health Council
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- Duell, Eric J. (författare)
- Catalan Institute of Oncology
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- Ardanaz, Eva (författare)
- Spanish Center for Biomedical Research Network in Oncology (CIBERONC)
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Larranaga, Nerea (författare)
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- Lundin, Eva (författare)
- Umeå universitet,Patologi
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- Idahl, Annika, 1965- (författare)
- Umeå University,Umeå universitet,Obstetrik och gynekologi
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- Jirström, Karin (författare)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Personlig patologi och cancerbehandling,Forskargrupper vid Lunds universitet,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Personalized Pathology & Cancer Therapy,Lund University Research Groups,Skåne University Hospital
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- Nodin, Björn (författare)
- Lund University,Lunds universitet,Personlig patologi och cancerbehandling,Forskargrupper vid Lunds universitet,Personalized Pathology & Cancer Therapy,Lund University Research Groups,Skåne University Hospital
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Travis, Ruth C. (författare)
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- Riboli, Elio (författare)
- Imperial College London
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Merritt, Melissa (författare)
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- Aune, Dagfinn (författare)
- Imperial College London
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Terry, Kathryn (författare)
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Cramer, Daniel W. (författare)
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Anderson, Karen S. (författare)
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(creator_code:org_t)
- 2018-03-08
- 2018
- Engelska.
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Ingår i: International Journal of Cancer. - : Wiley-Blackwell. - 0020-7136 .- 1097-0215. ; 143:3, s. 515-526
- Relaterad länk:
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https://onlinelibrar...
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http://dx.doi.org/10...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Immuno-proteomic screening has identified several tumor-associated autoantibodies (AAb) that may have diagnostic capacity for invasive epithelial ovarian cancer, with AAbs to P53 proteins and cancer-testis antigens (CTAGs) as prominent examples. However, the early detection potential of these AAbs has been insufficiently explored in prospective studies. We performed ELISA measurements of AAbs to CTAG1A, CTAG2, P53 and NUDT11 proteins, for 194 patients with ovarian cancer and 705 matched controls from the European EPIC cohort, using serum samples collected up to 36 months prior to diagnosis under usual care. CA125 was measured using electrochemo-luminiscence. Diagnostic discrimination statistics were calculated by strata of lead-time between blood collection and diagnosis. With lead times 6 months, ovarian cancer detection sensitivity at 0.98 specificity (SE98) varied from 0.19 [95% CI 0.08-0.40] for CTAG1A, CTAG2 and NUDT1 to 0.23 [0.10-0.44] for P53 (0.33 [0.11-0.68] for high-grade serous tumors). However, at longer lead-times, the ability of these AAb markers to distinguish future ovarian cancer cases from controls declined rapidly; at lead times >1 year, SE98 estimates were close to zero (all invasive cases, range: 0.01-0.11). Compared to CA125 alone, combined logistic regression scores of AAbs and CA125 did not improve detection sensitivity at equal level of specificity. The added value of these selected AAbs as markers for ovarian cancer beyond CA125 for early detection is therefore limited. What's new? Could autoantibodies against tumor antigens provide an early warning system for ovarian cancer? These authors tested how well certain antibodies detected ovarian cancer. They selected four candidate antibodies, to p53, CTAG1A, CTAG2 and NUDT11 proteins, which appear in elevated levels in cancer patients. None of them performed well as a herald of burgeoning cancer. They did not perform any better than the best currently available biomarker, CA125, and as lead times increased past 6 months prediagnosis, the effectiveness diminished. Surprisingly, elevated antibodies appeared in quite a few of the control samples, suggesting they might not be as cancer-specific as expected.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Reproduktionsmedicin och gynekologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Obstetrics, Gynaecology and Reproductive Medicine (hsv//eng)
Nyckelord
- early detection
- antibodies
- prospective validation
- Antibodies
- Early detection
- Prospective validation
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Kaaks, Rudolf
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Fortner, Renée T ...
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Hüsing, Anika
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Barrdahl, Myrto
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Hopper, Marika
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Johnson, Theron
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visa fler...
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Tjønneland, Anne
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Hansen, Louise
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Overvad, Kim
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Fournier, Agnès
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Boutron-Ruault, ...
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Kvaskoff, Marina
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Dossus, Laure
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Johansson, Matti ...
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Boeing, Heiner
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Trichopoulou, An ...
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Benetou, Vassili ...
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La Vecchia, Carl ...
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Sieri, Sabina
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Mattiello, Amali ...
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Palli, Domenico
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Tumino, Rosario
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Matullo, Giusepp ...
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Onland-Moret, N. ...
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Gram, Inger T.
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Weiderpass, Elis ...
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Sánchez, Maria-J ...
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Navarro Sanchez, ...
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Duell, Eric J.
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Ardanaz, Eva
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Larranaga, Nerea
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Lundin, Eva
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Idahl, Annika, 1 ...
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Jirström, Karin
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Nodin, Björn
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Travis, Ruth C.
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Riboli, Elio
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Merritt, Melissa
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Aune, Dagfinn
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Terry, Kathryn
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Cramer, Daniel W ...
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Anderson, Karen ...
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Umeå universitet
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Karolinska Institutet
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