Association of Polygenic Score for Schizophrenia and HLA Antigen and Inflammation Genes With Response to Lithium in Bipolar Affective Disorder: A Genome-Wide Association Study.

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Fältnamn	Indikatorer	Metadata
000		09017naa a2201681 4500
001		oai:gup.ub.gu.se/261213
003		SwePub
008		240528s2018 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:prod.swepub.kib.ki.se:137400510
024	7	a https://gup.ub.gu.se/publication/2612132 URI
024	7	a https://doi.org/10.1001/jamapsychiatry.2017.34332 DOI
024	7	a http://kipublications.ki.se/Default.aspx?queryparsed=id:1374005102 URI
040		a (SwePub)gud (SwePub)ki
041		a eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Amare, Azmeraw T4 aut
245	1 0	a Association of Polygenic Score for Schizophrenia and HLA Antigen and Inflammation Genes With Response to Lithium in Bipolar Affective Disorder: A Genome-Wide Association Study.
264		c 2017-11-09
264	1	b American Medical Association (AMA),c 2018
520		a Lithium is a first-line mood stabilizer for the treatment of bipolar affective disorder (BPAD). However, the efficacy of lithium varies widely, with a nonresponse rate of up to 30%. Biological response markers are lacking. Genetic factors are thought to mediate treatment response to lithium, and there is a previously reported genetic overlap between BPAD and schizophrenia (SCZ).To test whether a polygenic score for SCZ is associated with treatment response to lithium in BPAD and to explore the potential molecular underpinnings of this association.A total of 2586 patients with BPAD who had undergone lithium treatment were genotyped and assessed for long-term response to treatment between 2008 and 2013. Weighted SCZ polygenic scores were computed at different P value thresholds using summary statistics from an international multicenter genome-wide association study (GWAS) of 36989 individuals with SCZ and genotype data from patients with BPAD from the Consortium on Lithium Genetics. For functional exploration, a cross-trait meta-GWAS and pathway analysis was performed, combining GWAS summary statistics on SCZ and response to treatment with lithium. Data analysis was performed from September 2016 to February 2017.Treatment response to lithium was defined on both the categorical and continuous scales using the Retrospective Criteria of Long-Term Treatment Response in Research Subjects with Bipolar Disorder score. The effect measures include odds ratios and the proportion of variance explained.Of the 2586 patients in the study (mean [SD] age, 47.2 [13.9] years), 1478 were women and 1108 were men. The polygenic score for SCZ was inversely associated with lithium treatment response in the categorical outcome, at a threshold P<5×10-2. Patients with BPAD who had a low polygenic load for SCZ responded better to lithium, with odds ratios for lithium response ranging from 3.46 (95% CI, 1.42-8.41) at the first decile to 2.03 (95% CI, 0.86-4.81) at the ninth decile, compared with the patients in the 10th decile of SCZ risk. In the cross-trait meta-GWAS, 15 genetic loci that may have overlapping effects on lithium treatment response and susceptibility to SCZ were identified. Functional pathway and network analysis of these loci point to the HLA antigen complex and inflammatory cytokines.This study provides evidence for a negative association between high genetic loading for SCZ and poor response to lithium in patients with BPAD. These results suggest the potential for translational research aimed at personalized prescribing of lithium.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicin0 (SwePub)3022 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicine0 (SwePub)3022 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng
700	1	a Schubert, Klaus Oliver4 aut
700	1	a Hou, Liping4 aut
700	1	a Clark, Scott R4 aut
700	1	a Papiol, Sergi4 aut
700	1	a Heilbronner, Urs4 aut
700	1	a Degenhardt, Franziska4 aut
700	1	a Tekola-Ayele, Fasil4 aut
700	1	a Hsu, Yi-Hsiang4 aut
700	1	a Shekhtman, Tatyana4 aut
700	1	a Adli, Mazda4 aut
700	1	a Akula, Nirmala4 aut
700	1	a Akiyama, Kazufumi4 aut
700	1	a Ardau, Raffaella4 aut
700	1	a Arias, Bárbara4 aut
700	1	a Aubry, Jean-Michel4 aut
700	1	a Backlund, Lenau Karolinska Institutet4 aut
700	1	a Bhattacharjee, Abesh Kumar4 aut
700	1	a Bellivier, Frank4 aut
700	1	a Benabarre, Antonio4 aut
700	1	a Bengesser, Susanne4 aut
700	1	a Biernacka, Joanna M4 aut
700	1	a Birner, Armin4 aut
700	1	a Brichant-Petitjean, Clara4 aut
700	1	a Cervantes, Pablo4 aut
700	1	a Chen, Hsi-Chung4 aut
700	1	a Chillotti, Caterinau Karolinska Institutet4 aut
700	1	a Cichon, Sven4 aut
700	1	a Cruceanu, Cristiana4 aut
700	1	a Czerski, Piotr M4 aut
700	1	a Dalkner, Nina4 aut
700	1	a Dayer, Alexandre4 aut
700	1	a Del Zompo, Maria4 aut
700	1	a DePaulo, J Raymond4 aut
700	1	a Étain, Bruno4 aut
700	1	a Falkai, Peter4 aut
700	1	a Forstner, Andreas J4 aut
700	1	a Frisen, Louiseu Karolinska Institutet4 aut
700	1	a Frye, Mark A4 aut
700	1	a Fullerton, Janice M4 aut
700	1	a Gard, Sébastien4 aut
700	1	a Garnham, Julie S4 aut
700	1	a Goes, Fernando S4 aut
700	1	a Grigoroiu-Serbanescu, Maria4 aut
700	1	a Grof, Paul4 aut
700	1	a Hashimoto, Ryota4 aut
700	1	a Hauser, Joanna4 aut
700	1	a Herms, Stefan4 aut
700	1	a Hoffmann, Per4 aut
700	1	a Hofmann, Andrea4 aut
700	1	a Jamain, Stephane4 aut
700	1	a Jiménez, Esther4 aut
700	1	a Kahn, Jean-Pierre4 aut
700	1	a Kassem, Layla4 aut
700	1	a Kuo, Po-Hsiu4 aut
700	1	a Kato, Tadafumi4 aut
700	1	a Kelsoe, John4 aut
700	1	a Kittel-Schneider, Sarah4 aut
700	1	a Kliwicki, Sebastian4 aut
700	1	a König, Barbara4 aut
700	1	a Kusumi, Ichiro4 aut
700	1	a Laje, Gonzalo4 aut
700	1	a Landén, Mikael,d 1966u Karolinska Institutet,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry4 aut0 (Swepub:gu)xlandt
700	1	a Lavebratt, Catharina4 aut
700	1	a Leboyer, Marion4 aut
700	1	a Leckband, Susan G4 aut
700	1	a Tortorella, Alfonso4 aut
700	1	a Manchia, Mirkou Karolinska Institutet4 aut
700	1	a Martinsson, Linau Karolinska Institutet4 aut
700	1	a McCarthy, Michael J4 aut
700	1	a McElroy, Susan4 aut
700	1	a Colom, Francesc4 aut
700	1	a Mitjans, Marina4 aut
700	1	a Mondimore, Francis M4 aut
700	1	a Monteleone, Palmiero4 aut
700	1	a Nievergelt, Caroline M4 aut
700	1	a Nöthen, Markus M4 aut
700	1	a Novák, Tomas4 aut
700	1	a O'Donovan, Claire4 aut
700	1	a Ozaki, Norio4 aut
700	1	a Ösby, Urban4 aut
700	1	a Pfennig, Andrea4 aut
700	1	a Potash, James B4 aut
700	1	a Reif, Andreas4 aut
700	1	a Reininghaus, Eva4 aut
700	1	a Rouleau, Guy A4 aut
700	1	a Rybakowski, Janusz K4 aut
700	1	a Schalling, Martin4 aut
700	1	a Schofield, Peter R4 aut
700	1	a Schweizer, Barbara W4 aut
700	1	a Severino, Giovanni4 aut
700	1	a Shilling, Paul D4 aut
700	1	a Shimoda, Katzutaka4 aut
700	1	a Simhandl, Christian4 aut
700	1	a Slaney, Claire M4 aut
700	1	a Squassina, Alessio4 aut
700	1	a Stamm, Thomas4 aut
700	1	a Stopkova, Pavla4 aut
700	1	a Maj, Mario4 aut
700	1	a Turecki, Gustavo4 aut
700	1	a Vieta, Eduard4 aut
700	1	a Volkert, Julia4 aut
700	1	a Witt, Stephanie4 aut
700	1	a Wright, Adam4 aut
700	1	a Zandi, Peter P4 aut
700	1	a Mitchell, Philip B4 aut
700	1	a Bauer, Michael4 aut
700	1	a Alda, Martin4 aut
700	1	a Rietschel, Marcella4 aut
700	1	a McMahon, Francis J4 aut
700	1	a Schulze, Thomas G4 aut
700	1	a Baune, Bernhard T4 aut
710	2	a Karolinska Institutetb Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi4 org
773	0	t JAMA psychiatryd : American Medical Association (AMA)g 75:1, s. 65-74q 75:1<65-74x 2168-6238x 2168-622X
856	4	u https://jamanetwork.com/journals/jamapsychiatry/articlepdf/2663274/jamapsychiatry_amare_2017_oi_170082.pdf
856	4 8	u https://gup.ub.gu.se/publication/261213
856	4 8	u https://doi.org/10.1001/jamapsychiatry.2017.3433
856	4 8	u http://kipublications.ki.se/Default.aspx?queryparsed=id:137400510

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Av författaren/redakt...: Amare, Azmeraw T; Schubert, Klaus ...; Hou, Liping; Clark, Scott R; Papiol, Sergi; Heilbronner, Urs; visa fler...; Degenhardt, Fran ...; Tekola-Ayele, Fa ...; Hsu, Yi-Hsiang; Shekhtman, Tatya ...; Adli, Mazda; Akula, Nirmala; Akiyama, Kazufum ...; Ardau, Raffaella; Arias, Bárbara; Aubry, Jean-Mich ...; Backlund, Lena; Bhattacharjee, A ...; Bellivier, Frank; Benabarre, Anton ...; Bengesser, Susan ...; Biernacka, Joann ...; Birner, Armin; Brichant-Petitje ...; Cervantes, Pablo; Chen, Hsi-Chung; Chillotti, Cater ...; Cichon, Sven; Cruceanu, Cristi ...; Czerski, Piotr M; Dalkner, Nina; Dayer, Alexandre; Del Zompo, Maria; DePaulo, J Raymo ...; Étain, Bruno; Falkai, Peter; Forstner, Andrea ...; Frisen, Louise; Frye, Mark A; Fullerton, Janic ...; Gard, Sébastien; Garnham, Julie S; Goes, Fernando S; Grigoroiu-Serban ...; Grof, Paul; Hashimoto, Ryota; Hauser, Joanna; Herms, Stefan; Hoffmann, Per; Hofmann, Andrea; Jamain, Stephane; Jiménez, Esther; Kahn, Jean-Pierr ...; Kassem, Layla; Kuo, Po-Hsiu; Kato, Tadafumi; Kelsoe, John; Kittel-Schneider ...; Kliwicki, Sebast ...; König, Barbara; Kusumi, Ichiro; Laje, Gonzalo; Landén, Mikael, ...; Lavebratt, Catha ...; Leboyer, Marion; Leckband, Susan ...; Tortorella, Alfo ...; Manchia, Mirko; Martinsson, Lina; McCarthy, Michae ...; McElroy, Susan; Colom, Francesc; Mitjans, Marina; Mondimore, Franc ...; Monteleone, Palm ...; Nievergelt, Caro ...; Nöthen, Markus M; Novák, Tomas; O'Donovan, Clair ...; Ozaki, Norio; Ösby, Urban; Pfennig, Andrea; Potash, James B; Reif, Andreas; Reininghaus, Eva; Rouleau, Guy A; Rybakowski, Janu ...; Schalling, Marti ...; Schofield, Peter ...; Schweizer, Barba ...; Severino, Giovan ...; Shilling, Paul D; Shimoda, Katzuta ...; Simhandl, Christ ...; Slaney, Claire M; Squassina, Aless ...; Stamm, Thomas; Stopkova, Pavla; Maj, Mario; Turecki, Gustavo; Vieta, Eduard; Volkert, Julia; Witt, Stephanie; Wright, Adam; Zandi, Peter P; Mitchell, Philip ...; Bauer, Michael; Alda, Martin; Rietschel, Marce ...; McMahon, Francis ...; Schulze, Thomas ...; Baune, Bernhard ...; visa färre...

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