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Sökning: WFRF:(Bergen Sarah E) > The role of ADHD ge...

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FältnamnIndikatorerMetadata
00005007naa a2200457 4500
001oai:DiVA.org:oru-98538
003SwePub
008220412s2022 | |||||||||||000 ||eng|
009oai:prod.swepub.kib.ki.se:149227743
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-985382 URI
0247 a https://doi.org/10.1038/s41398-022-01919-92 DOI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1492277432 URI
040 a (SwePub)orud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Garcia-Argibay, Miguel,d 1988-u Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden4 aut0 (Swepub:oru)mlgy
2451 0a The role of ADHD genetic risk in mid-to-late life somatic health conditions
264 c 2022-04-11
264 1b Nature Publishing Group,c 2022
338 a print2 rdacarrier
500 a Funding agencies:United States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Institute of Mental Health (NIMH) R21MH116188  Estonian Research Council PSG615Correction: The role of ADHD genetic risk in mid-to-late life somatic health conditions. Garcia-Argibay, M., du Rietz, E., Lu, Y. et al. Transl Psychiatry 12, 166 (2022). https://doi.org/10.1038/s41398-022-01933-x
520 a Growing evidence suggests that ADHD, an early onset neurodevelopmental disorder, is associated with poor somatic health in adulthood. However, the mechanisms underlying these associations are poorly understood. Here, we tested whether ADHD polygenic risk scores (PRS) are associated with mid-to-late life somatic health in a general population sample. Furthermore, we explored whether potential associations were moderated and mediated by life-course risk factors. We derived ADHD-PRS in 10,645 Swedish twins born between 1911 and 1958. Sixteen cardiometabolic, autoimmune/inflammatory, and neurological health conditions were evaluated using self-report (age range at measure 42-88 years) and clinical diagnoses defined by International Classification of Diseases codes in national registers. We estimated associations of ADHD-PRS with somatic outcomes using generalized estimating equations, and tested moderation and mediation of these associations by four life-course risk factors (education level, body mass index [BMI], tobacco use, alcohol misuse). Results showed that higher ADHD-PRS were associated with increased risk of seven somatic outcomes (heart failure, cerebro- and peripheral vascular disease, obesity, type 1 diabetes, rheumatoid arthritis, and migraine) with odds ratios ranging 1.07 to 1.20. We observed significant mediation effects by education, BMI, tobacco use, and alcohol misuse, primarily for associations of ADHD-PRS with cardiometabolic outcomes. No moderation effects survived multiple testing correction. Our findings suggests that higher ADHD genetic liability confers a modest risk increase for several somatic health problems in mid-to-late life, particularly in the cardiometabolic domain. These associations were observable in the general population, even in the absence of medical treatment for ADHD, and appear to be in part mediated by life-course risk factors.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Psykiatri0 (SwePub)302152 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Psychiatry0 (SwePub)302152 hsv//eng
7001 a du Rietz, Ebbau Karolinska Institutet4 aut
7001 a Lu, Yiu Karolinska Institutet4 aut
7001 a Martin, Joannau Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK4 aut
7001 a Haan, Elisu Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia4 aut
7001 a Letho, Kelliu Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia4 aut
7001 a Bergen, Sarah E.u Karolinska Institutet4 aut
7001 a Lichtenstein, Paulu Karolinska Institutet4 aut
7001 a Larsson, Henrik,d 1975-u Örebro universitet,Institutionen för medicinska vetenskaper,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden4 aut0 (Swepub:oru)hiln
7001 a Brikell, Isabellu Karolinska Institutet4 aut
7102 a Örebro universitetb Institutionen för medicinska vetenskaper4 org
7730 t Translational Psychiatryd : Nature Publishing Groupg 12:1q 12:1x 2158-3188
8564 u https://doi.org/10.1038/s41398-022-01919-9y Fulltext
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-98538
8564 8u https://doi.org/10.1038/s41398-022-01919-9
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:149227743

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