WFRF:(Blanc H)
Sökning: WFRF:(Blanc H) > (2020-2024) > Grading of minor sa...
- 10 av 26
- Föregående post
- Nästa post
- Till träfflistan
Grading of minor salivary gland immuno-histopathology post-allogenic hematopoietic cell transplantation
-
- Tollemar, V. (författare)
- Karolinska Institutet
-
- Arvidsson, H. (författare)
- Karolinska Institutet
-
- Häbel, H. (författare)
- Karolinska Institutet
- visa fler...
- visa färre...
- (creator_code:org_t)
- Cell Press, 2023
- 2023
- Engelska.
- Ingår i: Heliyon. - : Cell Press. - 2405-8440. ; 9:4
- Tidskriftsartikel (refereegranskat)
Abstract
Ämnesord
Stäng
- Objectives: The oral cavity commonly displays mucosal lichenoid lesions and salivary gland dysfunction, which are considered different chronic Graft-versus-Host Disease (cGVHD) patho-physiology's. However, diagnostics of salivary gland (sg-)cGVHD are limited. The objectives of the current study are to evaluate the minor salivary gland (MSG) histo-immunopathological profiles post allogenic hematopoietic cell transplantation based on sg-cGVHD criteria. Design: Histopathology was characterized according to two published grading strategies. Firstly, the National Institute of Health (NIH) assessed peri-ductal/acinar infiltration, exocytosis, damage, and fibrosis, and a points-based grading scheme was established (0-16 points, Grade (G) 0 to IV). Second, a modified Sjo center dot gren's Syndrome focus-score with parenchymal damage was also adapted, (0-10 points, Score 0 to 2). 146 MSG biopsies from 79 patients were compared, using the his-topathological specific criteria for sg-cGVHD pathology. Quantitative immunohistochemistry for T-cells (CD4, CD8), B-cells (CD19, CD20), monocytic cells (CD68) and dendritic cells (CD1a) were also assessed. Results: The large-scale cohort validated the use of both grading schemes. GIII-GIV and score 2 signified a histopathological diagnosis of "likely" sg-cGVHD. Immunopathological severity was associated with increased T-cells (CD4 and CD8) and monocytic (CD68) infiltrate, with minimal involvement of B-cells (CD19 and CD20), and Langerhans cells (CD1a). Conclu-sions: Both schemes were verified as being suitable for histological grading to improve assess-ment and diagnosis of sg-cGVHD. The NIH cGVHD grading appears to be more beneficial for research purposes, including final diagnostics of "no/inactive", "possible" or "likely" cGVHD. The study highlights the intricacies of sg-cGVHD pathology; and the need for standardized assessment to improve patient management associated to sg-cGVHD.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Odontologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Dentistry (hsv//eng)
Nyckelord
- Oral cGVHD
- Histopathology
- Grading
- Large cohort
- Hematopoietic cell transplantation
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
- 10 av 26
- Föregående post
- Nästa post
- Till träfflistan
Hitta mer i SwePub
- Av författaren/redakt...
- Tollemar, V.
- Arvidsson, H.
- Häbel, H.
- Tudzarovski, N.
- Legert, K. Garmi ...
- Le Blanc, K.
- visa fler...
- Warfvinge, Gunna ...
- Sugars, R. V.
- visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
- MEDICIN OCH HÄLS ...
- och Klinisk medicin
- och Odontologi
- Artiklar i publikationen
- Heliyon
- Av lärosätet
- Malmö universitet
- Karolinska Institutet
Sök utanför SwePub
- Sök vidare i:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - Nationella bibliotekssystem
- LIBRIS.kb.se
