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FältnamnIndikatorerMetadata
00010913naa a2201033 4500
001oai:DiVA.org:uu-420700
003SwePub
008200930s2020 | |||||||||||000 ||eng|
009oai:lup.lub.lu.se:1c8b5af7-73ee-4b30-9dc6-7a8f26cb2286
009oai:prod.swepub.kib.ki.se:144299122
024a https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4207002 URI
024a https://doi.org/10.1002/uog.221252 DOI
024a https://lup.lub.lu.se/record/1c8b5af7-73ee-4b30-9dc6-7a8f26cb22862 URI
024a http://kipublications.ki.se/Default.aspx?queryparsed=id:1442991222 URI
040 a (SwePub)uud (SwePub)lud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
100a Stampalija, T.u IRCCS Burlo Garofolo, Inst Maternal & Child Hlth, Unit Fetal Med & Prenatal Diag, Trieste, Italy.;Univ Trieste, Dept Med Surg & Hlth Sci, Trieste, Italy.,University of Trieste,Burlo Garofolo Pediatric Institute4 aut
2451 0a Fetal cerebral Doppler changes and outcome in late preterm fetal growth restriction :b prospective cohort study
264 c 2020-08
264 1b Wiley,c 2020
338 a electronic2 rdacarrier
520 a Objectives To explore the association between fetal umbilical and middle cerebral artery (MCA) Doppler abnormalities and outcome in late preterm pregnancies at risk of fetal growth restriction. Methods This was a prospective cohort study of singleton pregnancies at risk of fetal growth restriction at 32+ 0 to 36+ 6weeks of gestation, enrolled in 33 European centers between 2017 and 2018, in which umbilical and fetal MCA Doppler velocimetry was performed. Pregnancies were considered at risk of fetal growth restriction if they had estimated fetal weight and/or abdominal circumference (AC) < 10th percentile, abnormal arterial Doppler and/or a fall in AC growth velocity of more than 40 percentile points from the 20-week scan. Composite adverse outcome comprised both immediate adverse birth outcome and major neonatal morbidity. Using a range of cut-off values, the association of MCA pulsatility index and umbilicocerebral ratio (UCR) with composite adverse outcome was explored. Results The study population comprised 856 women. There were two (0.2%) intrauterine deaths. Median gestational age at delivery was 38 (interquartile range (IQR), 37-39) weeks and birth weight was 2478 (IQR, 2140-2790) g. Compared with infants with normal outcome, those with composite adverse outcome (n= 93; 11%) were delivered at an earlier gestational age (36 vs 38 weeks) and had a lower birth weight (1900 vs 2540 g). The first Doppler observation of MCA pulsatility index < 5th percentile and UCR Z-score above gestational-age-specific thresholds (1.5 at 32-33weeks and 1.0 at 34-36weeks) had the highest relative risks (RR) for composite adverse outcome (RR 2.2 (95% CI, 1.5-3.2) and RR 2.0 (95% CI, 1.4-3.0), respectively). After adjustment for confounders, the association between UCR Z-score and composite adverse outcome remained significant, although gestational age at delivery and birth-weight Z-score had a stronger association. Conclusion In this prospective multicenter study, signs of cerebral blood flow redistribution were found to be associated with adverse outcome in late preterm singleton pregnancies at risk of fetal growth restriction. Whether cerebral redistribution is a marker describing the severity of fetal growth restriction or an independent risk factor for adverse outcome remains unclear, and whether it is useful for clinical management can be answered only in a randomized trial. (C) 2020 The Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of the International Society of Ultrasound in Obstetrics and Gynecology.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Reproduktionsmedicin och gynekologi0 (SwePub)302202 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Obstetrics, Gynaecology and Reproductive Medicine0 (SwePub)302202 hsv//eng
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Radiologi och bildbehandling0 (SwePub)302082 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Radiology, Nuclear Medicine and Medical Imaging0 (SwePub)302082 hsv//eng
653 a adverse outcome
653 a Doppler
653 a middle cerebral artery
653 a neonatal
653 a umbilical artery
653 a umbilicocerebral ratio
653 a adverse outcome
653 a Doppler
653 a middle cerebral artery
653 a neonatal
653 a umbilical artery
653 a umbilicocerebral ratio
700a Thornton, J.u Univ Nottingham, Div Obstet & Gynaecol, City Hosp, Sch Clin Sci,Matern Dept, Nottingham, England.4 aut
700a Marlow, N.u UCL, UCL Elizabeth Garrett Anderson Inst Womens Hlth, London, England.4 aut
700a Napolitano, R.u UCL, UCL Elizabeth Garrett Anderson Inst Womens Hlth, London, England.;Univ Coll London Hosp NHS Fdn Trust, Fetal Med Unit, London, England.4 aut
700a Bhide, A.u St Georges Univ London, Fetal Med Unit, St Georges Univ Hosp NHS Fdn Trust, London, England.;St Georges Univ London, Mol & Clin Sci Res Inst, London, England.4 aut
700a Pickles, T.u Cardiff Univ, Coll Biomed & Life Sci, Ctr Trials Res, Cardiff, Wales.4 aut
700a Bilardo, C. M.u Univ Amsterdam, Amsterdam Univ Med Ctr, Amsterdam Reprod & Dev Res Inst, Dept Obstet & Gynecol, Amsterdam, Netherlands.;Univ Groningen, Univ Med Ctr Groningen, Dept Obstet & Gynaecol, Groningen, Netherlands.4 aut
700a Gordijn, S. J.u Univ Groningen, Univ Med Ctr Groningen, Dept Obstet & Gynaecol, Groningen, Netherlands.4 aut
700a Gyselaers, W.u Hasselt Univ, Fac Med & Life Sci, Agoralaan, Diepenbeek, Belgium.;Hasselt Univ, Ziekenhuis Oost Limburg, Dept Obstet & Gynaecol, Diepenbeek, Belgium.;Hasselt Univ, Dept Physiol, Diepenbeek, Belgium.4 aut
700a Valensise, H.u Tor Vergata Univ, Policlin Casilino Hosp, Div Obstet & Gynecol, Dept Surg, Rome, Italy.4 aut
700a Hecher, K.u Tor Vergata Univ, Policlin Casilino Hosp, Div Obstet & Gynecol, Dept Surg, Rome, Italy.;Univ Med Ctr Hamburg Eppendorf, Dept Obstet & Fetal Med, Hamburg, Germany.4 aut
700a Sande, R. K.u Stavanger Univ Hosp, Dept Obstet & Gynecol, Stavanger, Norway.;Univ Bergen, Dept Clin Sci, Bergen, Norway.4 aut
700a Lindgren, P.u Karolinska Institutet4 aut
700a Bergman, Eva,d 1959-u Uppsala universitet,Obstetrisk och reproduktiv hälsoforskning4 aut0 (Swepub:uu)evber534
700a Arabin, B.u Humboldt Univ, Dept Obstet Charite, Berlin, Germany.;Clara Angela Fdn, Berlin, Germany.4 aut
700a Breeze, A. C.u Leeds Teaching Hosp NHS Trust, Leeds Gen Infirm, Fetal Med Unit, Leeds, W Yorkshire, England.4 aut
700a Wee, L.u Princess Alexandra Hosp NHS Trust, Harlow, Essex, England.4 aut
700a Ganzevoort, W.u Univ Amsterdam, Amsterdam Univ Med Ctr, Amsterdam Reprod & Dev Res Inst, Dept Obstet & Gynecol, Amsterdam, Netherlands.4 aut
700a Richter, J.u Katholieke Univ Leuven, UZ Leuven, Dept Gynecol & Obstet, Leuven, Belgium.;Katholieke Univ Leuven, Dept Regenerat & Dev, Leuven, Belgium.4 aut
700a Berger, A.u Med Univ Innsbruck, Dept Obstet & Gynecol, Innsbruck, Austria.4 aut
700a Brodszki, Janau Lund University,Lunds universitet,Obstetrik och gynekologi, Lund,Sektion V,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Obstetrics and Gynaecology (Lund),Section V,Department of Clinical Sciences, Lund,Faculty of Medicine,Skåne University Hospital4 aut0 (Swepub:lu)gyn-jko
700a Derks, J.u Univ Utrecht, Dept Perinatal Med, Utrecht, Netherlands.4 aut
700a Mecacci, F.u Univ Florence, Obstet & Gynecol, Careggi Univ Hosp, Dept Hlth Sci, Florence, Italy.4 aut
700a Maruotti, G. M.u Univ Naples Federico II, Dept Neurosci Reprod & Dent Sci, Naples, Italy.4 aut
700a Myklestad, K.u St Olavs Hosp, Trondheim, Norway.4 aut
700a Lobmaier, S. M.u Tech Univ Munich, Klinikum Rechts Isar, Dept Obstet & Gynecol, Munich, Germany.4 aut
700a Prefumo, F.u ASST Spedali Civili Brescia, Dept Obstet & Gynecol, Brescia, Italy.;Univ Brescia, Brescia, Italy.4 aut
700a Klaritsch, P.u Med Univ Graz, Dept Obstet & Gynecol, Graz, Austria.4 aut
700a Calda, P.u Charles Univ Prague, Dept Obstet & Gynecol, Gen Univ Hosp, Prague, Czech Republic.;Charles Univ Prague, Fac Med 1, Prague, Czech Republic.4 aut
700a Ebbing, C.u Haukeland Hosp, Dept Obstet & Gynecol, Bergen, Norway.4 aut
700a Frusca, T.u Univ Parma, Dept Obstet & Gynecol, Parma, Italy.4 aut
700a Raio, L.u Univ Hosp Bern, Dept Obstet & Gynecol, Bern, Switzerland.4 aut
700a Visser, G. H. A.u Univ Med Ctr Utrecht, Div Woman & Baby, Dept Obstet, Utrecht, Netherlands.4 aut
700a Krofta, L.u Inst Care Mother & Child, Prague, Czech Republic.;Charles Univ Prague, Fac Med 3, Prague, Czech Republic.4 aut
700a Cetin, I.u Univ Milan, Vittore Buzzi Childrens Hosp, Dept Obstet & Gynecol, Milan, Italy.4 aut
700a Ferrazzi, E.u Univ Milan, Fdn IRCCS Ca Granda Osped Maggiore Policlin, Dept Obstet & Gynecol, Milan, Italy.;Univ Milan, Dept Clin Sci & Community Hlth, Milan, Italy.4 aut
700a Cesari, E.u Univ Milan, Vittore Buzzi Childrens Hosp, Dept Obstet & Gynecol, Milan, Italy.4 aut
700a Wolf, H.u Univ Amsterdam, Amsterdam Univ Med Ctr, Amsterdam Reprod & Dev Res Inst, Dept Obstet & Gynecol, Amsterdam, Netherlands.4 aut
700a Lees, C. C.u Imperial Coll London, Imperial Coll Sch Med, London, England.;Imperial Coll London, Queen Charlottes & Chelsea Hosp, Dept Fetal Med, London, England.,Imperial College London,Queen Charlotte's and Chelsea Hospital4 aut
710a IRCCS Burlo Garofolo, Inst Maternal & Child Hlth, Unit Fetal Med & Prenatal Diag, Trieste, Italy.;Univ Trieste, Dept Med Surg & Hlth Sci, Trieste, Italy.b University of Trieste4 org
773t Ultrasound in Obstetrics and Gynecologyd : Wileyg 56:2, s. 173-181q 56:2<173-181x 0960-7692x 1469-0705
856u https://doi.org/10.1002/uog.22125y Fulltext
856u https://uu.diva-portal.org/smash/get/diva2:1471985/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
856u https://obgyn.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/uog.22125
856u http://dx.doi.org/10.1002/uog.22125x freey FULLTEXT
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-420700
8564 8u https://doi.org/10.1002/uog.22125
8564 8u https://lup.lub.lu.se/record/1c8b5af7-73ee-4b30-9dc6-7a8f26cb2286
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:144299122

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