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Obesity and Weight Gain Since Early Adulthood Are Associated With a Lower Risk of Microscopic Colitis

Liu, Po-Hong (författare)
Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston Massachusetts, USA
Burke, Kristin E. (författare)
Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston Massachusetts, USA; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston Massachusetts, USA
Ananthakrishnan, Ashwin N. (författare)
Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston Massachusetts, USA; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston Massachusetts, USA
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Lochhead, Paul (författare)
Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston Massachusetts, USA; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston Massachusetts, USA
Olen, Ola (författare)
Karolinska Institutet
Ludvigsson, Jonas F., 1969- (författare)
Karolinska Institutet,Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Pediatrics, Örebro University Hospital, Örebro University, Örebro, Sweden
Richter, James M. (författare)
Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston Massachusetts, USA; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston Massachusetts, USA
Chan, Andrew T. (författare)
Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston Massachusetts, USA; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston Massachusetts, USA; Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, Massachusetts, USA; Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Massachusetts, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston Massachusetts, USA
Khalili, Hamed (författare)
Clinical and Translational Epidemiology Unit, Massachusetts General Hospital and Harvard Medical School, Boston Massachusetts, USA; Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston Massachusetts, USA; Department of Medicine, Clinical Epidemiology Unit, Karolinska Institutet, Stockholm, Sweden
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 (creator_code:org_t)
Elsevier, 2019
2019
Engelska.
Ingår i: Clinical Gastroenterology and Hepatology. - : Elsevier. - 1542-3565 .- 1542-7714. ; 17:12, s. 2523-2532
Relaterad länk:
https://www.ncbi.nlm...
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https://urn.kb.se/re...
https://doi.org/10.1...
http://kipublication...
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  • Tidskriftsartikel (refereegranskat)
Abstract Ämnesord
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  • BACKGROUND & AIMS: Obesity promotes intestinal inflammation and might contribute to the pathogenesis of inflammatory bowel disease. We examined the association between obesity and risk of microscopic colitis in a prospective cohort study.METHODS: We collected data from 192,101 women enrolled in the Nurses' Health Study (NHS) (from 1986 through 2014) or the NHSII (from 1991 through 2015). Anthropomorphic and lifestyle information were self-reported biennially. Obesity was defined using body mass index (BMI). Microscopic colitis was confirmed by review of medical records. We used Cox proportional hazard models to estimate adjusted hazard ratios (aHRs) and 95% CIs. RESULTS: Among the participants in the NHS and NHSII, we confirmed 244 cases of microscopic colitis during 4,223,868 person-years of follow-up evaluation. Higher BMI was associated inversely with risk of microscopic colitis (Ptrend < .001). Compared with women with BMIs ranging from 18.5 to 20.9 kg/m(2), the aHRs were 0.61 (95% CI, 0.41-0.91) for overweight women (BMI, 2529.9 kg/m(2)) and 0.50 (95% CI, 0.32-0.79) for obese women (BMI >= 30 kg/m(2)). The aHR for each 5-kg/m(2) increase in BMI was 0.79 (95% CI, 0.69-0.90). Weight gain since early adulthood (age, 18 y) also was associated inversely with risk of microscopic colitis (Ptrend = .001). The aHR for each 10-kg weight gain since early adulthood was 0.85 (95% CI, 0.77-0.94). The associations were not modified by age, cohort, physical activity, or smoking status (all Pinteraction >= .26).CONCLUSIONS: Unlike many other immune- and metabolic-related disorders, obesity and weight gain since early adulthood were associated with a lower risk of microscopic colitis, based on an analysis of participants in the NHS and NHSII.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Gastroenterologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Gastroenterology and Hepatology (hsv//eng)

Nyckelord

Body Mass Index
Waist to Hip Ratio
Collagenous Colitis
Lymphocytic Colitis
Epidemiology

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