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Plasma neurofilamen...
Plasma neurofilament light chain is elevated after transcatheter aortic valve implantation
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- Sjölin, Karl (author)
- Uppsala universitet,Neurologi
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- Christersson, Christina (author)
- Uppsala universitet,Kardiologi
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- James, Stefan, 1964- (author)
- Uppsala universitet,Kardiologi,Uppsala kliniska forskningscentrum (UCR)
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- Lindbäck, Johan (author)
- Uppsala universitet,Uppsala kliniska forskningscentrum (UCR)
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- Åsberg, Signild, 1972- (author)
- Uppsala universitet,Neurologi
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- Burman, Joachim, 1974- (author)
- Uppsala universitet,Experimentell neurologi
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(creator_code:org_t)
- S. Karger, 2023
- 2023
- English.
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In: Cardiology. - : S. Karger. - 0008-6312 .- 1421-9751. ; 148:5, s. 478-483
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https://uu.diva-port... (primary) (Raw object)
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Abstract
Subject headings
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- Introduction: Transcatheter aortic valve implantation (TAVI) is associated with a high incidence of new silent brain infarcts (SBIs) on postprocedural neuroimaging. A venous blood sample reflecting neuronal damage following TAVI could help identify patients with potential SBIs. We aimed to investigate if a biochemical marker of neuronal injury, neurofilament light chain (NFL), is elevated after TAVI.Methods: In this observational study, NFL was measured in plasma from 31 patients before and after TAVI. Multivariable regression analysis was performed to investigate any effect of clinical- and procedure-related factors on differences in NFL levels before and after TAVI. Results: Samples were collected 41 (14–81) days before and 44 (35–59) days after TAVI, median (interquartile range). Median age was 81 (77–84) years, and 35% were female. No patient had any overt procedure-related neurological complications. The geometric mean (95% confidence interval) of the NFL concentration was 30 (25–36) pg/mL before TAVI and 48 (39–61) pg/mL, after TAVI, p <0.001. None of the included variables in the multiple linear regression model were statistically significantly associated with the difference in levels before and after TAVI.Conclusions: NFL levels in plasma were higher after TAVI as compared with levels before, with a mean increase of 60% (18 pg/mL). Further studies including neuroimaging and cognitive outcomes are needed to understand the potential value of measuring NFL in relation to TAVI.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Keyword
- Transcatheter aortic valve implantation
- Neurofilament
- Silent brain infarcts
- Biochemical markers
- Clinical research
Publication and Content Type
- ref (subject category)
- art (subject category)
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