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Frequent somatic tr...
Frequent somatic transfer of mitochondrial DNA into the nuclear genome of human cancer cells.
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Ju, Young Seok (author)
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Tubio, Jose M C (author)
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Mifsud, William (author)
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Fu, Beiyuan (author)
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Davies, Helen R (author)
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Ramakrishna, Manasa (author)
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Li, Yilong (author)
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Yates, Lucy (author)
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Gundem, Gunes (author)
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Tarpey, Patrick S (author)
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Behjati, Sam (author)
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Papaemmanuil, Elli (author)
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Martin, Sancha (author)
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Fullam, Anthony (author)
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Gerstung, Moritz (author)
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Nangalia, Jyoti (author)
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Green, Anthony R (author)
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Caldas, Carlos (author)
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- Borg, Åke (author)
- Lund University,Lunds universitet,Bröstcancer-genetik,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Breastcancer-genetics,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine
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Tutt, Andrew (author)
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Lee, Ming Ta Michael (author)
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Van't Veer, Laura J (author)
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Tan, Benita K T (author)
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Aparicio, Samuel (author)
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Span, Paul N (author)
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Martens, John W M (author)
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Knappskog, Stian (author)
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Vincent-Salomon, Anne (author)
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Børresen-Dale, Anne-Lise (author)
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Eyfjörd, Jórunn Erla (author)
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Flanagan, Adrienne M (author)
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Foster, Christopher (author)
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Neal, David E (author)
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Cooper, Colin (author)
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Eeles, Rosalind (author)
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Lakhani, Sunil R (author)
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Desmedt, Christine (author)
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Thomas, Gilles (author)
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Richardson, Andrea L (author)
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Purdie, Colin A (author)
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Thompson, Alastair M (author)
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McDermott, Ultan (author)
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Yang, Fengtang (author)
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Nik-Zainal, Serena (author)
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Campbell, Peter J (author)
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Stratton, Michael R (author)
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- Ehinger, Anna (creator_code:cre_t)
- Lund University,Lunds universitet,Tumörmikromiljö,Sektion I,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Bröstcancer-genetik,Institutionen för kliniska vetenskaper, Lund,Tumor microenvironment,Section I,Department of Clinical Sciences, Lund,Faculty of Medicine,Breastcancer-genetics,Department of Clinical Sciences, Lund
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(creator_code:org_t)
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- 2015-05-11
- 2015
- English.
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In: Genome Research. - : Cold Spring Harbor Laboratory. - 1549-5469 .- 1088-9051. ; 25:6, s. 814-824
- Related links:
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https://portal.resea... (primary) (free)
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http://www.ncbi.nlm....
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http://dx.doi.org/10...
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http://genome.cshlp....
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https://lup.lub.lu.s...
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https://doi.org/10.1...
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Abstract
Subject headings
Close
- Mitochondrial genomes are separated from the nuclear genome for most of the cell cycle by the nuclear double membrane, intervening cytoplasm, and the mitochondrial double membrane. Despite these physical barriers, we show that somatically acquired mitochondrial-nuclear genome fusion sequences are present in cancer cells. Most occur in conjunction with intranuclear genomic rearrangements, and the features of the fusion fragments indicate that nonhomologous end joining and/or replication-dependent DNA double-strand break repair are the dominant mechanisms involved. Remarkably, mitochondrial-nuclear genome fusions occur at a similar rate per base pair of DNA as interchromosomal nuclear rearrangements, indicating the presence of a high frequency of contact between mitochondrial and nuclear DNA in some somatic cells. Transmission of mitochondrial DNA to the nuclear genome occurs in neoplastically transformed cells, but we do not exclude the possibility that some mitochondrial-nuclear DNA fusions observed in cancer occurred years earlier in normal somatic cells.
Subject headings
- NATURVETENSKAP -- Biologi -- Genetik (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Genetics (hsv//eng)
Publication and Content Type
- art (subject category)
- ref (subject category)
Find in a library
To the university's database
- By the author/editor
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Ju, Young Seok
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Tubio, Jose M C
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Mifsud, William
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Fu, Beiyuan
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Davies, Helen R
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Ramakrishna, Man ...
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show more...
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Li, Yilong
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Yates, Lucy
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Gundem, Gunes
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Tarpey, Patrick ...
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Behjati, Sam
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Papaemmanuil, El ...
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Martin, Sancha
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Fullam, Anthony
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Gerstung, Moritz
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Nangalia, Jyoti
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Green, Anthony R
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Caldas, Carlos
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Borg, Åke
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Tutt, Andrew
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Lee, Ming Ta Mic ...
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Van't Veer, Laur ...
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Tan, Benita K T
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Aparicio, Samuel
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Span, Paul N
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Martens, John W ...
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Knappskog, Stian
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Vincent-Salomon, ...
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Børresen-Dale, A ...
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Eyfjörd, Jórunn ...
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Flanagan, Adrien ...
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Foster, Christop ...
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Neal, David E
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Cooper, Colin
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Eeles, Rosalind
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Lakhani, Sunil R
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Desmedt, Christi ...
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Thomas, Gilles
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Richardson, Andr ...
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Purdie, Colin A
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Thompson, Alasta ...
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McDermott, Ultan
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Yang, Fengtang
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Nik-Zainal, Sere ...
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Campbell, Peter ...
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Stratton, Michae ...
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Ehinger, Anna
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- About the subject
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Biological Scien ...
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and Genetics
- Articles in the publication
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Genome Research
- By the university
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Lund University