Sökning: WFRF:(Collin Matthew) >
Graft-versus-Host D...
Graft-versus-Host Disease Prophylaxis with PostTransplantation Cyclophosphamide in Chronic Myeloid Leukemia Patients Undergoing Allogeneic Hematopoietic Cell Transplantation from an Unrelated or Mismatched Related Donor : A Comparative Study from the Chronic Malignancies Working Party of the EBMT (CMWP-EBMT)
-
- Ortí, Guillermo (författare)
- Vall dHebron Univ Hosp, Vall dHebron Inst Oncol, Dept Hematol, Barcelona, Spain.
-
- Gras, Luuk (författare)
- EBMT Stat Unit, Leiden, Netherlands.
-
- Koster, Linda (författare)
- EBMT Leiden Study Unit, Leiden, Netherlands.
-
visa fler...
-
- Kulagin, Aleksander (författare)
- Pavlov Univ, RM Gorbacheva Res Inst, St Petersburg, Russia.
-
- Byrne, Jenny (författare)
- Univ Nottingham, Nottingham, England.
-
- Apperley, Jane F. (författare)
- Imperial Coll, London, England.
-
- Halaburda, Kazimierz (författare)
- Inst Hematol & Transfus Med, Warsaw, Poland.
-
- Blau, Igor Wolfgang (författare)
- Charite Univ Med Berlin, Berlin, Germany.
-
- Clark, Andrew (författare)
- Beatson West Scotland Canc Ctr, Glasgow, Lanark, Scotland.
-
- Kröger, Nicolaus (författare)
- Univ Hosp Eppendorf, Hamburg, Germany.
-
- Griskevicius, Laimonas (författare)
- Vilnius Univ Hosp, Vilnius, Lithuania.
-
- Carlson, Kristina (författare)
- Univ Hosp, Uppsala, Sweden
-
- Collin, Matthew (författare)
- Northern Ctr Bone Marrow Transplantat, Newcastle Upon Tyne, Tyne & Wear, England.
-
- Bloor, Adrian (författare)
- Christie NHS Trust Hosp, Manchester, Lancs, England.
-
- Raiola, Anna Maria (författare)
- IRCCS Osped Policlin San Martino, Genoa, Italy.
-
- Blaise, Didier (författare)
- Programme Transplantat & Therapie Cellulaire, Marseille, France.
-
- Aljurf, Mahmoud (författare)
- King Faisal Specialist Hosp & Res Ctr, Riyadh, Saudi Arabia.
-
- López-Corral, Lucia (författare)
- Hosp Univ Salamanca, Dept Hematol, IBSAL, CIBERONC, Salamanca, Spain.
-
- Sakellari, Ioanna (författare)
- George Papanicolaou Gen Hosp, Thessaloniki, Greece.
-
- Beguin, Yves (författare)
- Univ Liege, Liege, Belgium.;CHU Liege, Liege, Belgium.
-
- Wrobel, Tomasz (författare)
- Wroclaw Med Univ, Wroclaw, Poland.
-
- de Rosa, Luca (författare)
- Osped S Camillo Forlanini, Rome, Italy.
-
- de Lavallade, Hughes (författare)
- Guys & St Thomas NHS Fdn Trust, London, England.
-
- Hayden, Patrick J. (författare)
- Trinity Coll Dublin, St Jamess Hosp, Dublin, Ireland.
-
- McLornan, Donal (författare)
- Univ Coll Hosp, London, England.
-
- Chalandon, Yves (författare)
- Univ Geneva, Hop Univ Geneva, Div Hematol, Geneva, Switzerland.;Univ Geneva, Hop Univ Geneve, Fac Med, Geneva, Switzerland.
-
- Yakoub-Agha, Ibrahim (författare)
- Univ Lille, CHU Lille, INSERM, U1286,Infinite, F-59000 Lille, France.
-
visa färre...
-
Vall dHebron Univ Hosp, Vall dHebron Inst Oncol, Dept Hematol, Barcelona, Spain EBMT Stat Unit, Leiden, Netherlands. (creator_code:org_t)
- Elsevier, 2024
- 2024
- Engelska.
-
Ingår i: Transplantation and Cellular Therapy. - : Elsevier. - 2666-6375 .- 2666-6367. ; 30:1, s. 93.e1-93.e12
- Relaterad länk:
-
https://urn.kb.se/re...
-
visa fler...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- Outcomes following allogeneic hematopoietic cell transplantation (allo-HCT) for chronic myeloid leukemia (CML) with post-transplantation cyclophosphamide (PTCy) using an unrelated donor (UD) or a mismatched related donor (MMRD) remain unknown. We report a retrospective comparison of PTCy-based allo-HCT from a UD, non-PTCy allo-HCT from a UD, and PTCy allo-HCT from an MMRD. Inclusion criteria were adult patients with CML undergoing first allo-HCT between 2012 and 2019 from a UD with either PTCy or non-PTCy graft-versus-host disease (GVHD) prophylaxis or from an MMRD using PTCy. The primary endpoint was GVHD-free/relapse-free survival (GRFS). A total of 1341 patients were included (82% in the non-PTCy UD cohort). With a median follow-up of 34.9 months, the 3-year GRFS was 43% in the non-PTCy cohort, 37% in the PTCy-UD cohort, and 39% PTCy-MMRD cohort (P = .15). Multivariable analyses revealed no significant differences among the 3 cohorts in terms of overall survival (OS), progression-free survival, RI, and nonrelapse mortality. Factors independently associated with worse OS in the overall cohort were Karnofsky Performance Status <90 (hazard ratio [HR], 1.86; 95% confidence interval [CI], 1.41 to 2.45; P < .001), older age (HR, 1.24, 95% CI, 1.11 to 1.38; P < .001), and disease stage (compared to chronic phase [CP] 1): blast phase (HR, 2.25; 95% CI, 1.60 to 3.16; P < .001), accelerated phase (HR, 1.63; 95% CI, 1.05 to 2.54; P = .03), and CP >2 (HR, 1.58; 95% CI, 1.15 to 2.17; P = .005). These results suggest that allo-HCT in patients with CML using either a UD or an MMRD with PTCy-based GVHD prophylaxis are feasible transplantation, platforms and that the disease stage at allo-HCT remains a major prognostic factor, highlighting the importance of closely monitoring CML patients and proposing transplantation when indicated when still in CP1.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Hematologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Hematology (hsv//eng)
Nyckelord
- Allogeneic hematopoietic cell transplantation
- Chronic myeloid
- leukemia
- Post-transplantation
- cyclophosphamide
- Unrelated donor
- Haploidentical donor
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Ortí, Guillermo
-
Gras, Luuk
-
Koster, Linda
-
Kulagin, Aleksan ...
-
Byrne, Jenny
-
Apperley, Jane F ...
-
visa fler...
-
Halaburda, Kazim ...
-
Blau, Igor Wolfg ...
-
Clark, Andrew
-
Kröger, Nicolaus
-
Griskevicius, La ...
-
Carlson, Kristin ...
-
Collin, Matthew
-
Bloor, Adrian
-
Raiola, Anna Mar ...
-
Blaise, Didier
-
Aljurf, Mahmoud
-
López-Corral, Lu ...
-
Sakellari, Ioann ...
-
Beguin, Yves
-
Wrobel, Tomasz
-
de Rosa, Luca
-
de Lavallade, Hu ...
-
Hayden, Patrick ...
-
McLornan, Donal
-
Chalandon, Yves
-
Yakoub-Agha, Ibr ...
-
visa färre...
- Om ämnet
-
- MEDICIN OCH HÄLSOVETENSKAP
-
MEDICIN OCH HÄLS ...
-
och Klinisk medicin
-
och Hematologi
- Artiklar i publikationen
-
Transplantation ...
- Av lärosätet
-
Uppsala universitet