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Pilot study on long...
Pilot study on longitudinal change in pancreatic proton density fat fraction during a weight-loss surgery program in adults with obesity
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- Covarrubias, Yesenia (author)
- Univ Calif San Diego, CA 92093 USA
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- Fowler, Kathryn J. (author)
- Univ Calif San Diego, CA 92093 USA
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- Mamidipalli, Adrija (author)
- Univ Calif San Diego, CA 92093 USA
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- Hamilton, Gavin (author)
- Univ Calif San Diego, CA 92093 USA
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- Wolfson, Tanya (author)
- Univ Calif San Diego, CA 92093 USA
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- Dahlqvist Leinhard, Olof, 1978- (author)
- Linköpings universitet,Avdelningen för radiologiska vetenskaper,Medicinska fakulteten,Centrum för medicinsk bildvetenskap och visualisering, CMIV,Region Östergötland, Radiofysikavdelningen US,AMRA Med AB, Linkoping, Sweden
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- Jacobsen, Garth (author)
- Univ Calif San Diego, CA 92093 USA
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- Horgan, Santiago (author)
- Univ Calif San Diego, CA 92093 USA
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- Schwimmer, Jeffrey B. (author)
- Univ Calif San Diego, CA 92093 USA; Rady Childrens Hosp San Diego, CA USA
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- Reeder, Scott B. (author)
- Univ Wisconsin, WI 53706 USA; Univ Wisconsin, WI 53706 USA; Univ Wisconsin, WI USA; Univ Wisconsin, WI USA
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- Sirlin, Claude B. (author)
- Univ Calif San Diego, CA 92093 USA
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(creator_code:org_t)
- 2019-01-30
- 2019
- English.
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In: Journal of Magnetic Resonance Imaging. - : WILEY. - 1053-1807 .- 1522-2586. ; 50:4, s. 1092-1102
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https://www.ncbi.nlm...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- Background Quantitative-chemical-shift-encoded (CSE)-MRI methods have been applied to the liver. The feasibility and potential utility CSE-MRI in monitoring changes in pancreatic proton density fat fraction (PDFF) have not yet been demonstrated. Purpose To use quantitative CSE-MRI to estimate pancreatic fat changes during a weight-loss program in adults with severe obesity and nonalcoholic fatty liver disease (NAFLD). To explore the relationship of reduction in pancreatic PDFF with reductions in anthropometric indices. Study Type Prospective/longitudinal. Population Nine adults with severe obesity and NAFLD enrolled in a weight-loss program. Field Strength/Sequence CSE-MRI fat quantification techniques and multistation-volumetric fat/water separation techniques were performed at 3 T. Assessment PDFF values were recorded from parametric maps colocalized across timepoints. Statistical Tests Rates of change of log-transformed variables across time were determined (linear-regression), and their significance assessed compared with no change (Wilcoxon test). Rates of change were correlated pairwise (Spearmans correlation). Results Mean pancreatic PDFF decreased by 5.7% (range 0.7-17.7%) from 14.3 to 8.6%, hepatic PDFF by 11.4% (2.6-22.0%) from 14.8 to 3.4%, weight by 30.9 kg (17.3-64.2 kg) from 119.0 to 88.1 kg, body mass index by 11.0 kg/m(2) (6.3-19.1 kg/m(2)) from 44.1 to 32.9 kg/m(2), waist circumference (WC) by 25.2 cm (4.0-41.0 cm) from 133.1 to 107.9 cm, HC by 23.5 cm (4.5-47.0 cm) from 135.8 to 112.3 cm, visceral adipose tissue (VAT) by 2.9 L (1.7-5.7 L) from 7.1 to 4.2 L, subcutaneous adipose tissue (SCAT) by 4.0 L (2.9-7.4 L) from 15.0 to 11.0 L. Log-transformed rate of change for pancreatic PDFF was moderately correlated with log-transformed rates for hepatic PDFF, VAT, SCAT, and WC (rho = 0.5, 0.47, 0.45, and 0.48, respectively), although not statistically significant. Data Conclusion Changes in pancreatic PDFF can be estimated by quantitative CSE-MRI in adults undergoing a weight-loss surgery program. Pancreatic and hepatic PDFF and anthropometric indices decreased significantly. Technical Efficacy Stage: 1 J. Magn. Reson. Imaging 2019;50:1092-1102.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Radiologi och bildbehandling (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Radiology, Nuclear Medicine and Medical Imaging (hsv//eng)
Keyword
- proton density fat fraction; pancreatic PDFF; quantitative CSE-MRI; weight-loss surgery (WLS) program; longitudinal change
Publication and Content Type
- ref (subject category)
- art (subject category)
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Covarrubias, Yes ...
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Fowler, Kathryn ...
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Mamidipalli, Adr ...
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Hamilton, Gavin
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Wolfson, Tanya
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Dahlqvist Leinha ...
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Jacobsen, Garth
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Horgan, Santiago
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Schwimmer, Jeffr ...
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Reeder, Scott B.
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Sirlin, Claude B ...
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- MEDICAL AND HEALTH SCIENCES
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Linköping University