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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00009978naa a2201153 4500
001oai:DiVA.org:umu-189079
003SwePub
008211109s2021 | |||||||||||000 ||eng|
009oai:DiVA.org:oru-93441
009oai:DiVA.org:liu-182940
009oai:prod.swepub.kib.ki.se:148716539
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1890792 URI
0247 a https://doi.org/10.1053/j.gastro.2021.07.0262 DOI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-934412 URI
0247 a https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-1829402 URI
0247 a http://kipublications.ki.se/Default.aspx?queryparsed=id:1487165392 URI
040 a (SwePub)umud (SwePub)orud (SwePub)liud (SwePub)ki
041 a engb eng
042 9 SwePub
072 7a ref2 swepub-contenttype
072 7a art2 swepub-publicationtype
1001 a Bergemalm, Daniel,d 1977-u Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden,Orebro Univ, Sweden4 aut0 (Swepub:oru)dbm
2451 0a Systemic Inflammation in Preclinical Ulcerative Colitis
264 1b AGA Institute,c 2021
338 a electronic2 rdacarrier
500 a Funding agencies:Bengt Ihre research foundationOrebro University Hospital Research Foundation OLL-709831 OLL-936004 OLL-890291 OLL-790011 OLL-723021
500 a Funding Agencies|Vasterbotten County Council; Swedish Research CouncilSwedish Research CouncilEuropean Commission [2020-02021, VR 2017-00650]; EU FP7 grant: IBD-CHARACTER [2858546]; Bengt Ihre research foundation; Orebro University Hospital Research Foundation [OLL-709831, OLL-936004, OLL-890291, OLL-790011, OLL-723021]; Swedish Foundation For Strategic ResearchSwedish Foundation for Strategic Research [RB13-016]
520 a Background & Aims: Preclinical ulcerative colitis is poorly defined. We aimed to characterize the preclinical systemic inflammation in ulcerative colitis, using a comprehensive set of proteins.Methods: We obtained plasma samples biobanked from individuals who developed ulcerative colitis later in life (n = 72) and matched healthy controls (n = 140) within a population-based screening cohort. We measured 92 proteins related to inflammation using a proximity extension assay. The biologic relevance of these findings was validated in an inception cohort of patients with ulcerative colitis (n = 101) and healthy controls (n = 50). To examine the influence of genetic and environmental factors on these markers, a cohort of healthy twin siblings of patients with ulcerative colitis (n = 41) and matched healthy controls (n = 37) were explored.Results: Six proteins (MMP10, CXCL9, CCL11, SLAMF1, CXCL11 and MCP-1) were up-regulated (P < .05) in preclinical ulcerative colitis compared with controls based on both univariate and multivariable models. Ingenuity Pathway Analyses identified several potential key regulators, including interleukin-1β, tumor necrosis factor, interferon-gamma, oncostatin M, nuclear factor-κB, interleukin-6, and interleukin-4. For validation, we built a multivariable model to predict disease in the inception cohort. The model discriminated treatment-naïve patients with ulcerative colitis from controls with leave-one-out cross-validation (area under the curve = 0.92). Consistently, MMP10, CXCL9, CXCL11, and MCP-1, but not CCL11 and SLAMF1, were significantly up-regulated among the healthy twin siblings, even though their relative abundances seemed higher in incident ulcerative colitis.Conclusions: A set of inflammatory proteins are up-regulated several years before a diagnosis of ulcerative colitis. These proteins were highly predictive of an ulcerative colitis diagnosis, and some seemed to be up-regulated already at exposure to genetic and environmental risk factors.
650 7a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Gastroenterologi0 (SwePub)302132 hsv//swe
650 7a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Gastroenterology and Hepatology0 (SwePub)302132 hsv//eng
653 a CXCL9
653 a Inflammatory Bowel Disease
653 a MMP10
653 a Preclinical Disease
653 a Proximity Extension Assay
7001 a Andersson, Erik,d 1988-u Örebro universitet,Institutionen för medicinska vetenskaper,Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden,Orebro Univ, Sweden4 aut0 (Swepub:oru)edan
7001 a Hultdin, Johanu Umeå universitet,Klinisk kemi,Department of Medical Biosciences, Division of Clinical Chemistry, Umeå University, Umeå, Sweden,Umea Univ, Sweden4 aut0 (Swepub:umu)johu0007
7001 a Eriksson, Carl,d 1981-u Örebro universitet,Institutionen för medicinska vetenskaper,Region Örebro län,Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden,Orebro Univ, Sweden4 aut0 (Swepub:oru)clen
7001 a Rush, Stephen T.u School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden,Orebro Univ, Sweden4 aut
7001 a Kalla, Rahulu Medical Research Council Centre for Inflammation Research, Queens Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom,MRC Centre for Inflammation Research, Queens Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom,Univ Edinburgh, Scotland4 aut
7001 a Adams, Alex T.u Translational Gastroenterology Unit, Nuffield Department of Medicine, Experimental Medicine Division, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom,Univ Oxford, England4 aut
7001 a Keita, Åsau Linköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten4 aut0 (Swepub:liu)asave24
7001 a D'Amato, Maurou Karolinska Institutet4 aut
7001 a Gomollon, Fernandou Hospital Clinico Universitario Lozano Blesa, IIS Aragón, Zaragoza, Spain,HCU "Lozano Blesa," IIS Aragón, Zaragoza, Spain,Hosp Clin Univ Lozano Blesa, Spain4 aut
7001 a Jahnsen, Jørgenu Department of Gastroenterology, Akershus University Hospital, Lørenskog, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway,Akershus Univ Hosp, Norway; Univ Oslo, Norway4 aut
7001 a Arnott, Ian D.4 aut
7001 a Bayes, Monica4 aut
7001 a Bonfiglio, Ferdinando4 aut
7001 a Boyapati, Ray K.4 aut
7001 a Carstens, Adam4 aut
7001 a Casén, Christina4 aut
7001 a Ciemniejewska, Ewa4 aut
7001 a Dahl, Fredrik A.4 aut
7001 a Detlie, Trond Espen4 aut
7001 a Drummond, Hazel E.4 aut
7001 a Ekeland, Gunn S.4 aut
7001 a Ekman, Daniel4 aut
7001 a Frengen, Anna B.4 aut
7001 a Gullberg, Mats4 aut
7001 a Gut, Ivo G.4 aut
7001 a Gut, Marta4 aut
7001 a Heath, Simon C.4 aut
7001 a Hjelm, Fredrik4 aut
7001 a Hjortswang, Henrik4 aut
7001 a Ho, Gwo-Tzer4 aut
7001 a Jonkers, Daisy4 aut
7001 a Söderholm, Johan4 aut
7001 a Kennedy, Nicholas A.4 aut
7001 a Lees, Charles W.4 aut
7001 a Lindahl, Torbjørn4 aut
7001 a Lindqvist, Mårten4 aut
7001 a Merkel, Angelika4 aut
7001 a Modig, Eddie4 aut
7001 a Moen, Aina E.F.4 aut
7001 a Nilsen, Hilde4 aut
7001 a Nimmo, Elaine R.4 aut
7001 a Noble, Colin L.4 aut
7001 a Nordberg, Niklas4 aut
7001 a O'Leary, Kate R.4 aut
7001 a Ocklind, Anette4 aut
7001 a Olbjørn, Christine4 aut
7001 a Pettersson, Erik4 aut
7001 a Pierik, Marieke4 aut
7001 a Ricanek, Petru Department of Gastroenterology, Akershus University Hospital, Lørenskog, Norway,IBD character consortium,Akershus Univ Hosp, Norway4 aut
7001 a Satsangi, Jacku Translational Gastroenterology Unit, Nuffield Department of Medicine, Experimental Medicine Division, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom; Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom,Univ Oxford, England; Univ Edinburgh, Scotland4 aut
7001 a Repsilber, Dirk,d 1971-u Örebro universitet,Institutionen för medicinska vetenskaper,School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden,Orebro Univ, Sweden; Umea Univ, Sweden4 aut0 (Swepub:oru)drr
7001 a Karling, Pontusu Umeå universitet,Avdelningen för medicin,Department of Public Health and Clinical Medicine, Division of Medicine, Umeå University, Umeå, Sweden,Umea Univ, Sweden4 aut0 (Swepub:umu)peakag84
7001 a Halfvarson, Jonas,d 1970-u Örebro universitet,Institutionen för medicinska vetenskaper,Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden,Orebro Univ, Sweden4 aut0 (Swepub:oru)jshn
7102 a Örebro universitetb Institutionen för medicinska vetenskaper4 org
7730 t Gastroenterologyd : AGA Instituteg 161:5, s. 1526-1539.e9q 161:5<1526-1539.e9x 0016-5085x 1528-0012
8564 u https://doi.org/10.1053/j.gastro.2021.07.026y Fulltext
8564 u https://umu.diva-portal.org/smash/get/diva2:1609747/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 u http://www.gastrojournal.org/article/S0016508521032777/pdf
8564 u https://liu.diva-portal.org/smash/get/diva2:1639085/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-189079
8564 8u https://doi.org/10.1053/j.gastro.2021.07.026
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-93441
8564 8u https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-182940
8564 8u http://kipublications.ki.se/Default.aspx?queryparsed=id:148716539

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