CSF and blood biomarkers for Parkinson's disease.

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Fältnamn	Indikatorer	Metadata
000		04009naa a2200433 4500
001		oai:gup.ub.gu.se/288288
003		SwePub
008		240528s2019 \| \|\|\|\|\|\|\|\|\|\|\|000 \|\|eng\|
009		oai:lup.lub.lu.se:1e39b742-db65-4dcd-aca0-1fb79e7a4c0a
024	7	a https://gup.ub.gu.se/publication/2882882 URI
024	7	a https://doi.org/10.1016/S1474-4422(19)30024-92 DOI
024	7	a https://lup.lub.lu.se/record/1e39b742-db65-4dcd-aca0-1fb79e7a4c0a2 URI
040		a (SwePub)gud (SwePub)lu
041		a eng
042		9 SwePub
072	7	a ref2 swepub-contenttype
072	7	a art2 swepub-publicationtype
100	1	a Parnetti, Lucillau University of Perugia4 aut
245	1 0	a CSF and blood biomarkers for Parkinson's disease.
264	1	c 2019
520		a In the management of Parkinson's disease, reliable diagnostic and prognostic biomarkers are urgently needed. The diagnosis of Parkinson's disease mostly relies on clinical symptoms, which hampers the detection of the earliest phases of the disease-the time at which treatment with forthcoming disease-modifying drugs could have the greatest therapeutic effect. Reliable prognostic markers could help in predicting the response to treatments. Evidence suggests potential diagnostic and prognostic value of CSF and blood biomarkers closely reflecting the pathophysiology of Parkinson's disease, such as α-synuclein species, lysosomal enzymes, markers of amyloid and tau pathology, and neurofilament light chain. A combination of multiple CSF biomarkers has emerged as an accurate diagnostic and prognostic model. With respect to early diagnosis, the measurement of CSF α-synuclein aggregates is providing encouraging preliminary results. Blood α-synuclein species and neurofilament light chain are also under investigation because they would provide a non-invasive tool, both for early and differential diagnosis of Parkinson's disease versus atypical parkinsonian disorders, and for disease monitoring. In view of adopting CSF and blood biomarkers for improving Parkinson's disease diagnostic and prognostic accuracy, further validation in large independent cohorts is needed.
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng
650	7	a MEDICIN OCH HÄLSOVETENSKAPx Klinisk medicinx Neurologi0 (SwePub)302072 hsv//swe
650	7	a MEDICAL AND HEALTH SCIENCESx Clinical Medicinex Neurology0 (SwePub)302072 hsv//eng
700	1	a Gaetani, Lorenzou University of Perugia4 aut
700	1	a Eusebi, Paolou University of Perugia4 aut
700	1	a Paciotti, Silviau University of Perugia4 aut
700	1	a Hansson, Oskaru Lund University,Lunds universitet,Klinisk minnesforskning,Forskargrupper vid Lunds universitet,Clinical Memory Research,Lund University Research Groups,Skåne University Hospital4 aut0 (Swepub:lu)mphy-ohn
700	1	a El-Agnaf, Omaru Hamad Bin Khalifa University4 aut
700	1	a Mollenhauer, Britu University Medical Center Göttingen,Paracelsus-Elena-Klinik Kassel4 aut
700	1	a Blennow, Kaj,d 1958u University of Gothenburg,Gothenburg University,Göteborgs universitet,Institutionen för neurovetenskap och fysiologi, sektionen för psykiatri och neurokemi,Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry,Sahlgrenska University Hospital4 aut0 (Swepub:lu)med-kbw
700	1	a Calabresi, Paolou University of Perugia,IRCCS Fondazione Santa Lucia4 aut
710	2	a University of Perugiab Klinisk minnesforskning4 org
773	0	t The Lancet. Neurologyg 18:6, s. 573-586q 18:6<573-586x 1474-4465x 1474-4422
856	4	u http://dx.doi.org/10.1016/S1474-4422(19)30024-9y FULLTEXT
856	4 8	u https://gup.ub.gu.se/publication/288288
856	4 8	u https://doi.org/10.1016/S1474-4422(19)30024-9
856	4 8	u https://lup.lub.lu.se/record/1e39b742-db65-4dcd-aca0-1fb79e7a4c0a

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Av författaren/redakt...: Parnetti, Lucill ...; Gaetani, Lorenzo; Eusebi, Paolo; Paciotti, Silvia; Hansson, Oskar; El-Agnaf, Omar; visa fler...; Mollenhauer, Bri ...; Blennow, Kaj, 19 ...; Calabresi, Paolo; visa färre...

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MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Medicinska och f ...; och Neurovetenskaper

MEDICIN OCH HÄLSOVETENSKAP: MEDICIN OCH HÄLS ...; och Klinisk medicin; och Neurologi

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